PMID- 35805130
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20220828
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 13
DP  - 2022 Jun 28
TI  - The Interaction of mTOR and Nrf2 in Neurogenesis and Its Implication in 
      Neurodegenerative Diseases.
LID - 10.3390/cells11132048 [doi]
LID - 2048
AB  - Neurogenesis occurs in the brain during embryonic development and throughout 
      adulthood. Neurogenesis occurs in the hippocampus and under normal conditions and 
      persists in two regions of the brain-the subgranular zone (SGZ) in the dentate 
      gyrus of the hippocampus and the subventricular zone (SVZ) of the lateral 
      ventricles. As the critical role in neurogenesis, the neural stem cells have the 
      capacity to differentiate into various cells and to self-renew. This process is 
      controlled through different methods. The mammalian target of rapamycin (mTOR) 
      controls cellular growth, cell proliferation, apoptosis, and autophagy. The 
      transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a 
      major regulator of metabolism, protein quality control, and antioxidative 
      defense, and is linked to neurogenesis. However, dysregulation in neurogenesis, 
      mTOR, and Nrf2 activity have all been associated with neurodegenerative diseases 
      such as Alzheimer's, Huntington's, and Parkinson's. Understanding the role of 
      these complexes in both neurogenesis and neurodegenerative disease could be 
      necessary to develop future therapies. Here, we review both mTOR and Nrf2 
      complexes, their crosstalk and role in neurogenesis, and their implication in 
      neurodegenerative diseases.
FAU - Zoungrana, Linda Ines
AU  - Zoungrana LI
AD  - Department of Surgery, Morsani College of Medicine, University of South Florida, 
      Tampa, FL 33612, USA.
FAU - Krause-Hauch, Meredith
AU  - Krause-Hauch M
AD  - Department of Surgery, Morsani College of Medicine, University of South Florida, 
      Tampa, FL 33612, USA.
FAU - Wang, Hao
AU  - Wang H
AD  - Department of Surgery, Morsani College of Medicine, University of South Florida, 
      Tampa, FL 33612, USA.
FAU - Fatmi, Mohammad Kasim
AU  - Fatmi MK
AD  - Department of Surgery, Morsani College of Medicine, University of South Florida, 
      Tampa, FL 33612, USA.
FAU - Bates, Lauryn
AU  - Bates L
AD  - Department of Surgery, Morsani College of Medicine, University of South Florida, 
      Tampa, FL 33612, USA.
FAU - Li, Zehui
AU  - Li Z
AD  - Department of Medical Engineering, College of Engineering and Morsani College of 
      Medicine, University of South Florida, Tampa, FL 33612, USA.
FAU - Kulkarni, Parth
AU  - Kulkarni P
AD  - Department of Medical Engineering, College of Engineering and Morsani College of 
      Medicine, University of South Florida, Tampa, FL 33612, USA.
FAU - Ren, Di
AU  - Ren D
AD  - Department of Surgery, Morsani College of Medicine, University of South Florida, 
      Tampa, FL 33612, USA.
FAU - Li, Ji
AU  - Li J
AUID- ORCID: 0000-0002-0899-4412
AD  - Department of Surgery, Morsani College of Medicine, University of South Florida, 
      Tampa, FL 33612, USA.
LA  - eng
GR  - R01 GM124108/GM/NIGMS NIH HHS/United States
GR  - I01 BX005625/BX/BLRD VA/United States
GR  - R01 HL158515/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20220628
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (NF-E2-Related Factor 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Mammals
MH  - NF-E2-Related Factor 2
MH  - *Neurodegenerative Diseases
MH  - Neurogenesis/physiology
MH  - Sirolimus
MH  - TOR Serine-Threonine Kinases
PMC - PMC9265429
OTO - NOTNLM
OT  - Nrf2
OT  - mTOR
OT  - neurodegenerative diseases
OT  - neurogenesis
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/10 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/06/28
CRDT- 2022/07/09 01:05
PHST- 2022/05/23 00:00 [received]
PHST- 2022/06/23 00:00 [revised]
PHST- 2022/06/26 00:00 [accepted]
PHST- 2022/07/09 01:05 [entrez]
PHST- 2022/07/10 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/06/28 00:00 [pmc-release]
AID - cells11132048 [pii]
AID - cells-11-02048 [pii]
AID - 10.3390/cells11132048 [doi]
PST - epublish
SO  - Cells. 2022 Jun 28;11(13):2048. doi: 10.3390/cells11132048.