PMID- 35805984
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20230308
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 13
DP  - 2022 Jun 23
TI  - Impact of Zinc on Oxidative Signaling Pathways in the Development of Pulmonary 
      Vasoconstriction Induced by Hypobaric Hypoxia.
LID - 10.3390/ijms23136974 [doi]
LID - 6974
AB  - Hypobaric hypoxia is a condition that occurs at high altitudes (>2500 m) where 
      the partial pressure of gases, particularly oxygen (PO2), decreases. This 
      condition triggers several physiological and molecular responses. One of the 
      principal responses is pulmonary vascular contraction, which seeks to optimize 
      gas exchange under this condition, known as hypoxic pulmonary vasoconstriction 
      (HPV); however, when this physiological response is exacerbated, it contributes 
      to the development of high-altitude pulmonary hypertension (HAPH). Increased 
      levels of zinc (Zn2+) and oxidative stress (known as the "ROS hypothesis") have 
      been demonstrated in the vasoconstriction process. Therefore, the aim of this 
      review is to determine the relationship between molecular pathways associated 
      with altered Zn2+ levels and oxidative stress in HPV in hypobaric hypoxic 
      conditions. The results indicate an increased level of Zn2+, which is related to 
      increasing mitochondrial ROS (mtROS), alterations in nitric oxide (NO), 
      metallothionein (MT), zinc-regulated, iron-regulated transporter-like protein 
      (ZIP), and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-induced 
      protein kinase C epsilon (PKCepsilon) activation in the development of HPV. In 
      conclusion, there is an association between elevated Zn2+ levels and oxidative 
      stress in HPV under different models of hypoxia, which contribute to 
      understanding the molecular mechanism involved in HPV to prevent the development 
      of HAPH.
FAU - Arriaza, Karem
AU  - Arriaza K
AUID- ORCID: 0000-0003-1498-5579
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
FAU - Cuevas, Constanza
AU  - Cuevas C
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
FAU - Pena, Eduardo
AU  - Pena E
AUID- ORCID: 0000-0003-2664-1722
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
FAU - Siques, Patricia
AU  - Siques P
AUID- ORCID: 0000-0002-4963-195X
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
FAU - Brito, Julio
AU  - Brito J
AUID- ORCID: 0000-0002-0050-8774
AD  - Institute of Health Studies, Arturo Prat University, Iquique 1100000, Chile.
LA  - eng
GR  - BIP400187737-0/FIC GORE-TARAPACA/
PT  - Journal Article
PT  - Review
DEP - 20220623
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.6.3.- (NADPH Oxidases)
RN  - EC 2.7.11.13 (Protein Kinase C-epsilon)
RN  - J41CSQ7QDS (Zinc)
RN  - Pulmonary edema of mountaineers
SB  - IM
MH  - Altitude Sickness
MH  - Humans
MH  - Hypertension, Pulmonary
MH  - Hypoxia/metabolism
MH  - NADPH Oxidases/metabolism
MH  - Oxidative Stress
MH  - *Papillomavirus Infections/metabolism
MH  - Protein Kinase C-epsilon/metabolism
MH  - Pulmonary Artery/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction
MH  - *Vasoconstriction/physiology
MH  - Zinc/metabolism
PMC - PMC9266543
OTO - NOTNLM
OT  - hypobaric hypoxia
OT  - oxidative stress
OT  - protein kinase C
OT  - pulmonary vasoconstriction
OT  - zinc
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/10 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/06/23
CRDT- 2022/07/09 01:10
PHST- 2022/05/20 00:00 [received]
PHST- 2022/06/14 00:00 [revised]
PHST- 2022/06/20 00:00 [accepted]
PHST- 2022/07/09 01:10 [entrez]
PHST- 2022/07/10 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/06/23 00:00 [pmc-release]
AID - ijms23136974 [pii]
AID - ijms-23-06974 [pii]
AID - 10.3390/ijms23136974 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jun 23;23(13):6974. doi: 10.3390/ijms23136974.