PMID- 35807146
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 13
DP  - 2022 Jul 3
TI  - Mobile Cardiac Acoustic Monitoring System to Evaluate Left Ventricular Systolic 
      Function in Pacemaker Patients.
LID - 10.3390/jcm11133862 [doi]
LID - 3862
AB  - The mobile cardiac acoustic monitoring system is a promising tool to enable 
      detection and assist the diagnosis of left ventricular systolic dysfunction 
      (LVSD). The objective of the study was to evaluate the diagnostic value of 
      electromechanical activation time (EMAT), an important cardiac acoustic 
      biomarker, in quantifying LVSD among left bundle branch pacing (LBBP) and right 
      ventricular apical pacing (RVAP) patients using a mobile acoustic cardiography 
      monitoring system. In this prospective single-center observational study, 
      pacemaker-dependent patients were consecutively enrolled. EMAT, the time from the 
      start of the pacing QRS wave to first heart sound (S1) peak; left ventricular 
      systolic time (LVST), the time from S1 peak to S2 peak; and ECG were recorded 
      simultaneously by the mobile cardiac acoustic monitoring system. LVEF was 
      measured by echocardiography. A logistic regression model was applied to evaluate 
      the association between EMAT and reduced EF (LVEF < 50%). A total of 105 
      pacemaker-dependent patients participated. The RVAP group (n = 58) displayed a 
      significantly higher EMAT than the LBBP group (n = 47) (150.95 +/- 19.46 vs. 108.23 
      +/- 12.26 ms, p < 0.001). Pearson correlation analysis revealed a statistically 
      significant negative correlation between EMAT and LVEF (p < 0.001). Survival 
      analysis showed the sensitivity and specificity of detecting LVEF to be < 50% 
      when EMAT >/= 151 ms were 96.00% and 96.97% in the RVAP group. In LBBP patients, 
      the sensitivity and specificity of using EMAT >/= 110 ms as the cutoff value for 
      the detection of LVEF < 50% were 75.00% and 100.00%. There was no significant 
      difference in LVST with or without LVSD in the RVAP group (p = 0.823) and LBBP 
      group (p = 0.086). Compared to LVST, EMAT was more helpful to identify LVSD in 
      pacemaker-dependent patients. The cutoff point of EMAT for diagnosing LVEF < 50% 
      differed regarding the pacing type. Therefore, the mobile cardiac acoustic 
      monitoring system can be used to identify the progress of LVSD in pacemaker 
      patients.
FAU - Huang, Jingjuan
AU  - Huang J
AD  - Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai 200030, China.
FAU - Zhang, Weiwei
AU  - Zhang W
AD  - Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai 200030, China.
FAU - Pan, Changqing
AU  - Pan C
AD  - Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai 200030, China.
FAU - Zhu, Shiwei
AU  - Zhu S
AD  - Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai 200030, China.
FAU - Mead, Robert Hardwin
AU  - Mead RH
AD  - Silicon Valley Cardiology, East Palo Alto, CA 94303, USA.
FAU - Li, Ruogu
AU  - Li R
AD  - Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai 200030, China.
FAU - He, Ben
AU  - He B
AD  - Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, 
      Shanghai 200030, China.
LA  - eng
GR  - 81974051/National Natural Science Foundation of China/
GR  - 82070262/National Natural Science Foundation of China/
GR  - SHDC2020CR3026B/Clinical Research Plan of Shanghai Hospital Development Center 
      (SHDC)/
GR  - NO/Research physician of Medical School of Shanghai Jiao Tong University/
GR  - 202002009/Informatization Development Project of Shanghai Municipal Commission of 
      Economy and In-formatization/
PT  - Journal Article
DEP - 20220703
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9267668
OTO - NOTNLM
OT  - acoustic cardiography
OT  - electromechanical activation time (EMAT)
OT  - left bundle branch pacing (LBBP)
OT  - left ventricular systolic dysfunction (LVSD)
OT  - mobile monitoring
COIS- Mead is a consultant for iRhythm and Bayland Scientific. All other authors have 
      reported that they have no conflict relevant to the content of this paper to 
      disclose.
EDAT- 2022/07/10 06:00
MHDA- 2022/07/10 06:01
PMCR- 2022/07/03
CRDT- 2022/07/09 01:17
PHST- 2022/05/03 00:00 [received]
PHST- 2022/06/17 00:00 [revised]
PHST- 2022/06/30 00:00 [accepted]
PHST- 2022/07/09 01:17 [entrez]
PHST- 2022/07/10 06:00 [pubmed]
PHST- 2022/07/10 06:01 [medline]
PHST- 2022/07/03 00:00 [pmc-release]
AID - jcm11133862 [pii]
AID - jcm-11-03862 [pii]
AID - 10.3390/jcm11133862 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jul 3;11(13):3862. doi: 10.3390/jcm11133862.