PMID- 35807184
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 13
DP  - 2022 Jul 4
TI  - Safety and Effectiveness of Intravenous Iron Therapy in Patients Supported by 
      Durable Left Ventricular Assist Devices.
LID - 10.3390/jcm11133900 [doi]
LID - 3900
AB  - AIMS: While it is common practice to use intravenous (IV) iron in patients with 
      left ventricular assist devices (LVADs) and iron deficiency, there is 
      insufficient evidence regarding outcomes in this patient population. We evaluated 
      the safety and effectiveness of IV iron therapy in patients supported by LVADs 
      with iron deficiency. METHODS: We performed a retrospective analysis of iron 
      deficient patients on continuous LVAD support at a large academic center between 
      2008 and 2019. Patients were divided into two cohorts based on IV iron sucrose 
      treatment. The primary endpoint was hemoglobin at 12 weeks. Secondary endpoints 
      were mean corpuscular volume (MCV) and New York Heart Association (NYHA) class at 
      12 weeks. Safety endpoints included hospitalization, infection, pump thrombosis, 
      arrhythmia, and gastrointestinal bleed. Models were weighted by the inverse 
      probability of receiving IV iron using a propensity score, and endpoints were 
      adjusted for their corresponding baseline values. RESULTS: Among 213 patients, 70 
      patients received IV iron and 143 patients did not. Hemoglobin at 12 weeks was 
      significantly greater among those treated (intergroup difference: 0.6 g/dL; 95% 
      CI, 0.1 to 1.1; p = 0.01), while MCV was similar in both groups (intergroup 
      difference: 0.7 mum(3); 95% CI, -1.3 to 2.7; p = 0.50). NYHA class distribution at 
      12 weeks was significantly different (odds ratio for improvement: 2.84; 95% CI, 
      1.42 to 4.68; p = 0.003). The hazards of adverse events in each group were 
      similar. CONCLUSIONS: In patients with LVADs and iron deficiency, treatment with 
      IV iron sucrose was safe and associated with improvements in functional status 
      and hemoglobin.
FAU - Peters, Carli J
AU  - Peters CJ
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
FAU - Hanff, Thomas C
AU  - Hanff TC
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Department of Biostatistics, Epidemiology and Informatics, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
AD  - Cardiovascular Outcomes, Quality, and Evaluative Research Center, University of 
      Pennsylvania, Philadelphia, PA 19104, USA.
FAU - Genuardi, Michael V
AU  - Genuardi MV
AUID- ORCID: 0000-0002-8008-7526
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
FAU - Zhang, Robert
AU  - Zhang R
AUID- ORCID: 0000-0002-7946-6094
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
FAU - Domenico, Christopher
AU  - Domenico C
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Department of Pharmacy, Hospital of The University of Pennsylvania, Philadelphia, 
      PA 19104, USA.
FAU - Atluri, Pavan
AU  - Atluri P
AD  - Department of Cardiothoracic Surgery, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA 19104, USA.
FAU - Mazurek, Jeremy A
AU  - Mazurek JA
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
FAU - Urgo, Kim
AU  - Urgo K
AD  - Department of Cardiothoracic Surgery, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA 19104, USA.
FAU - Wald, Joyce
AU  - Wald J
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
FAU - Tanna, Monique S
AU  - Tanna MS
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
FAU - Shore, Supriya
AU  - Shore S
AD  - Cardiovascular Division, University of Michigan, Ann Arbor, MI 48109, USA.
FAU - Acker, Michael A
AU  - Acker MA
AD  - Department of Cardiothoracic Surgery, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA 19104, USA.
FAU - Goldberg, Lee R
AU  - Goldberg LR
AUID- ORCID: 0000-0002-7906-9638
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Cardiovascular Outcomes, Quality, and Evaluative Research Center, University of 
      Pennsylvania, Philadelphia, PA 19104, USA.
FAU - Margulies, Kenneth B
AU  - Margulies KB
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
FAU - Birati, Edo Y
AU  - Birati EY
AD  - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
AD  - Cardiovascular Outcomes, Quality, and Evaluative Research Center, University of 
      Pennsylvania, Philadelphia, PA 19104, USA.
AD  - The Lydia and Carol Kittner, Lea and Banjamin Davidai Division of Cardiovascular 
      Medicine and Surgery, Padeh-Poriya Medical Center, Azrieli Faculty of Medicine, 
      Bar-Ilan University, Ramat Gan 5290002, Israel.
LA  - eng
PT  - Journal Article
DEP - 20220704
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9267846
OTO - NOTNLM
OT  - intravenous iron
OT  - iron deficiency
OT  - left ventricular assist devices
COIS- E.Y.B.-Consulting fees from American Regent Inc. Research support paid to the 
      University of Pennsylvania from Medtronic Inc. KBM-sponsored research support 
      from Sanofi-Aventis USA and GlaxoSmithKline; consulting fees from MyoKardia and 
      Pfizer. Consulting fees from American Regent Inc. No other authors report any 
      direct conflicts pertinent to the development of this manuscript. All 
      investigators are affiliated with the University of Pennsylvania, which has 
      received clinical research support from Abbott and Medtronic. E.Y.B. has received 
      additional research support from Impulse Dynamics Ltd. and Medtronic Inc. to the 
      University of Pennsylvania.
EDAT- 2022/07/10 06:00
MHDA- 2022/07/10 06:01
PMCR- 2022/07/04
CRDT- 2022/07/09 01:17
PHST- 2022/05/01 00:00 [received]
PHST- 2022/06/21 00:00 [revised]
PHST- 2022/07/01 00:00 [accepted]
PHST- 2022/07/09 01:17 [entrez]
PHST- 2022/07/10 06:00 [pubmed]
PHST- 2022/07/10 06:01 [medline]
PHST- 2022/07/04 00:00 [pmc-release]
AID - jcm11133900 [pii]
AID - jcm-11-03900 [pii]
AID - 10.3390/jcm11133900 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jul 4;11(13):3900. doi: 10.3390/jcm11133900.