PMID- 35807237
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20220716
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 27
IP  - 13
DP  - 2022 Jun 21
TI  - (-)-alpha-Bisabolol Alleviates Atopic Dermatitis by Inhibiting MAPK and NF-kappaB 
      Signaling in Mast Cell.
LID - 10.3390/molecules27133985 [doi]
LID - 3985
AB  - (-)-alpha-Bisabolol (BIS) is a sesquiterpene alcohol derived mostly from Matricaria 
      recutita L., which is a traditional herb and exhibits multiple biologic 
      activities. BIS has been reported for treatment of skin disorders, but the effect 
      of BIS on anti-atopic dermatitis (AD) remains unclear. Therefore, we investigated 
      the effects of BIS on 2,4-dinitrochlorobenzene (DNCB)-induced AD in BALB/c mice 
      and the underlying mechanism in Bone Marrow-Derived Mast Cells (BMMCs). Topical 
      BIS treatment reduced AD-like symptoms and the release of interleukin (IL)-4 
      without immunoglobulin (Ig)-E production in DNCB-induced BALB/c mice. 
      Histopathological examination revealed that BIS reduced epidermal thickness and 
      inhibited mast cells in the AD-like lesions skin. Oral administration of BIS 
      effectively and dose-dependently suppressed mast-cell-mediated passive cutaneous 
      anaphylaxis. In IgE-mediated BMMCs, the levels of beta-hexosaminidase (beta-hex), 
      histamine, and tumor necrosis factor (TNF)-alpha were reduced by blocking the 
      activation of nuclear factor-қB (NF-қB) and c-Jun N-terminal kinase (JNK) without 
      P38 mitogen activated protein (P38) and extracellular regulated protein kinases 
      (Erk1/2). Taken together, our experimental results indicated BIS suppresses AD by 
      inhibiting the activation of JNK and NF-kappaB in mast cells. BIS may be a promising 
      therapeutic agent for atopic dermatitis and other mast-cell-related diseases.
FAU - Li, Guangxia
AU  - Li G
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 
      Cailun Road, Shanghai 201203, China.
AD  - Institute of Interdisciplinary Integrative Medicine Research, Shanghai University 
      of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
FAU - Wu, Huayan
AU  - Wu H
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 
      Cailun Road, Shanghai 201203, China.
FAU - Sun, Liqin
AU  - Sun L
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 
      Cailun Road, Shanghai 201203, China.
FAU - Cheng, Kang
AU  - Cheng K
AD  - Shanghai Inoherb Cosmetics Co., Ltd., Shanghai 200080, China.
FAU - Lv, Zhi
AU  - Lv Z
AD  - Shanghai Inoherb Cosmetics Co., Ltd., Shanghai 200080, China.
FAU - Chen, Kaixian
AU  - Chen K
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 
      Cailun Road, Shanghai 201203, China.
FAU - Qian, Fei
AU  - Qian F
AD  - Institute of Interdisciplinary Integrative Medicine Research, Shanghai University 
      of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
FAU - Li, Yiming
AU  - Li Y
AUID- ORCID: 0000-0003-3416-1331
AD  - School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 
      Cailun Road, Shanghai 201203, China.
LA  - eng
GR  - No. 81973458, 81903889/National Natural Science Foundation of China/
GR  - the Shanghai Science and Shanghai E-Research Institute of Bioactive Constituents 
      in Traditional Chinese Medicine/Shanghai University of Traditional Chinese 
      Medicine/
GR  - Shanghai Sailing Program (19YF1449100)/Shanghai Science and Technology 
      Development Foundation/
PT  - Journal Article
DEP - 20220621
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Monocyclic Sesquiterpenes)
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 24WE03BX2T (bisabolol)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Cytokines/metabolism
MH  - *Dermatitis, Atopic/chemically induced/drug therapy/metabolism
MH  - *Dinitrochlorobenzene/metabolism
MH  - Mast Cells
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Monocyclic Sesquiterpenes
MH  - NF-kappa B/metabolism
MH  - Skin/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
PMC - PMC9268635
OTO - NOTNLM
OT  - (-)-alpha-Bisabolol
OT  - JNK
OT  - NF-kappaB
OT  - atopic dermatitis
OT  - mast cells
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/10 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/06/21
CRDT- 2022/07/09 01:18
PHST- 2022/05/05 00:00 [received]
PHST- 2022/06/12 00:00 [revised]
PHST- 2022/06/18 00:00 [accepted]
PHST- 2022/07/09 01:18 [entrez]
PHST- 2022/07/10 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/06/21 00:00 [pmc-release]
AID - molecules27133985 [pii]
AID - molecules-27-03985 [pii]
AID - 10.3390/molecules27133985 [doi]
PST - epublish
SO  - Molecules. 2022 Jun 21;27(13):3985. doi: 10.3390/molecules27133985.