PMID- 35808924
OWN - NLM
STAT- MEDLINE
DCOM- 20220824
LR  - 20220826
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 36
IP  - 8
DP  - 2022 Aug
TI  - The etiological roles of miRNAs, lncRNAs, and circRNAs in neuropathic pain: A 
      narrative review.
PG  - e24592
LID - 10.1002/jcla.24592 [doi]
LID - e24592
AB  - BACKGROUND: Non-coding RNAs (ncRNAs) are involved in neuropathic pain 
      development. Herein, we systematically searched for neuropathic pain-related 
      ncRNAs expression changes, including microRNAs (miRNAs), long non-coding RNAs 
      (lncRNAs), and circular non-coding RNAs (circRNAs). METHODS: We searched two 
      databases, PubMed and GeenMedical, for relevant studies. RESULTS: Peripheral 
      nerve injury or noxious stimuli can induce extensive changes in the expression of 
      ncRNAs. For example, higher serum miR-132-3p, -146b-5p, and -384 was observed in 
      neuropathic pain patients. Either sciatic nerve ligation, dorsal root ganglion 
      (DRG) transaction, or ventral root transection (VRT) could upregulate miR-21 and 
      miR-31 while downregulating miR-668 and miR-672 in the injured DRG. lncRNAs, such 
      as early growth response 2-antisense-RNA (Egr2-AS-RNA) and Kcna2-AS-RNA, were 
      upregulated in Schwann cells and inflicted DRG after nerve injury, respectively. 
      Dysregulated circRNA homeodomain-interacting protein kinase 3 (circHIPK3) in 
      serum and the DRG, abnormally expressed lncRNAs X-inactive specific transcript 
      (XIST), nuclear enriched abundant transcript 1 (NEAT1), small nucleolar RNA host 
      gene 1 (SNHG1), as well as ciRS-7, zinc finger protein 609 (cirZNF609), 
      circ_0005075, and circAnks1a in the spinal cord were suggested to participate in 
      neuropathic pain development. Dysregulated miRNAs contribute to neuropathic pain 
      via neuroinflammation, autophagy, abnormal ion channel expression, regulating 
      pain-related mediators, protein kinases, structural proteins, neurotransmission 
      excitatory-inhibitory imbalances, or exosome miRNA-mediated neuron-glia 
      communication. In addition, lncRNAs and circRNAs are essential in neuropathic 
      pain by acting as antisense RNA and miRNA sponges, epigenetically regulating 
      pain-related molecules expression, or modulating miRNA processing. CONCLUSIONS: 
      Numerous dysregulated ncRNAs have been suggested to participate in neuropathic 
      pain development. However, there is much work to be done before ncRNA-based 
      analgesics can be clinically used for various reasons such as conservation among 
      species, proper delivery, stability, and off-target effects.
CI  - (c) 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Jiang, Ming
AU  - Jiang M
AD  - Department of Anesthesiology and Pain Medicine, Nanjing Maternity and Child 
      Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 
      China.
FAU - Wang, Yelong
AU  - Wang Y
AD  - Department of Anesthesiology, Gaochun People's Hospital, Nanjing, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Anesthesiology and Pain Medicine, Nanjing Maternity and Child 
      Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 
      China.
FAU - Feng, Shanwu
AU  - Feng S
AD  - Department of Anesthesiology and Pain Medicine, Nanjing Maternity and Child 
      Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 
      China.
FAU - Wang, Xian
AU  - Wang X
AUID- ORCID: 0000-0003-3922-9358
AD  - Department of Anesthesiology and Pain Medicine, Nanjing Maternity and Child 
      Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 
      China.
LA  - eng
GR  - BE2021615/Jiangsu Provincial Key Research and Development Program/
GR  - 81971040/National Natural Science Foundation of China/
GR  - 81971045/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20220709
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Circular)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Ganglia, Spinal
MH  - Humans
MH  - *MicroRNAs/genetics/metabolism
MH  - *Neuralgia/genetics/metabolism
MH  - RNA, Circular/genetics
MH  - *RNA, Long Noncoding/genetics/metabolism
PMC - PMC9396192
OTO - NOTNLM
OT  - circRNAs
OT  - lncRNAs
OT  - mechanism study
OT  - miRNAs
OT  - neuropathic pain
COIS- The authors declare no competing interest in this review.
EDAT- 2022/07/10 06:00
MHDA- 2022/08/25 06:00
PMCR- 2022/07/09
CRDT- 2022/07/09 03:23
PHST- 2022/06/24 00:00 [revised]
PHST- 2022/03/18 00:00 [received]
PHST- 2022/06/25 00:00 [accepted]
PHST- 2022/07/10 06:00 [pubmed]
PHST- 2022/08/25 06:00 [medline]
PHST- 2022/07/09 03:23 [entrez]
PHST- 2022/07/09 00:00 [pmc-release]
AID - JCLA24592 [pii]
AID - 10.1002/jcla.24592 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2022 Aug;36(8):e24592. doi: 10.1002/jcla.24592. Epub 2022 Jul 9.