PMID- 35810252
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20220916
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jul 9
TI  - Impact of chronic hepatitis on cardiovascular events among type 2 diabetes 
      patients in Taiwan pay-for-performance program.
PG  - 11720
LID - 10.1038/s41598-022-15827-x [doi]
LID - 11720
AB  - To investigate the impact of chronic hepatitis on cardiovascular events in 
      patients with type 2 diabetes mellitus (T2DM). This nationwide retrospective 
      cohort study included 152,709 adult patients (> 20 years) with T2DM enrolled in 
      the National Health Insurance Diabetes Pay-for-Performance Program from 2008 to 
      2010 and followed up until the end of 2017. Patients were categorized into groups 
      with hepatitis B, hepatitis C, fatty liver disease, and patients without chronic 
      hepatitis. The incidence of cardiovascular events in patients with T2DM and 
      hepatitis C (79.9/1000 person-years) was higher than that in patients with 
      diabetes combined with other chronic hepatitis, or without chronic hepatitis. 
      After adjusting for confounding factors, T2DM with fatty liver (adjusted hazard 
      ratio [HR]: 1.10; 95% confidence interval [CI]: 1.07-1.13) and hepatitis C 
      (adjusted HR: 1.09; 95% CI: 1.03-1.12) demonstrated a significantly higher risk 
      of cardiovascular events. The adjusted visit-to-visit coefficient of variation of 
      HbA1c and fasting blood glucose were associated with a high risk of 
      cardiovascular events (HRs of the highest quartile were 1.05 and 1.12, 
      respectively). Chronic hepatitis affects cardiovascular events in adult patients 
      with T2DM. Glucose variability could be an independent risk factor for 
      cardiovascular events in such patients.
CI  - (c) 2022. The Author(s).
FAU - Sheen, Yi-Jing
AU  - Sheen YJ
AD  - Department of Health Services Administration, China Medical University, No. 100, 
      Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan.
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan.
AD  - Department of Medicine, School of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Department of Public Health, China Medical University, Taichung, Taiwan.
FAU - Hsu, Chih-Cheng
AU  - Hsu CC
AD  - Department of Health Services Administration, China Medical University, No. 100, 
      Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan.
AD  - Institute of Population Health Sciences, National Health Research Institutes, 
      Zhunan, Taiwan.
FAU - Kung, Pei-Tseng
AU  - Kung PT
AD  - Department of Healthcare Administration, Asia University, Taichung, Taiwan.
AD  - Department of Medical Research, China Medical University Hospital, China Medical 
      University, Taichung, Taiwan.
FAU - Chiu, Li-Ting
AU  - Chiu LT
AD  - Department of Health Services Administration, China Medical University, No. 100, 
      Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan.
FAU - Tsai, Wen-Chen
AU  - Tsai WC
AD  - Department of Health Services Administration, China Medical University, No. 100, 
      Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan. 
      wctsai2011@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220709
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - *Cardiovascular Diseases/complications/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Hepatitis C/complications
MH  - *Hepatitis, Chronic/complications
MH  - Humans
MH  - Incidence
MH  - Reimbursement, Incentive
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Taiwan/epidemiology
PMC - PMC9271050
COIS- The authors declare no competing interests.
EDAT- 2022/07/10 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/07/09
CRDT- 2022/07/09 23:20
PHST- 2022/04/04 00:00 [received]
PHST- 2022/06/29 00:00 [accepted]
PHST- 2022/07/09 23:20 [entrez]
PHST- 2022/07/10 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/07/09 00:00 [pmc-release]
AID - 10.1038/s41598-022-15827-x [pii]
AID - 15827 [pii]
AID - 10.1038/s41598-022-15827-x [doi]
PST - epublish
SO  - Sci Rep. 2022 Jul 9;12(1):11720. doi: 10.1038/s41598-022-15827-x.