PMID- 35810551
OWN - NLM
STAT- MEDLINE
DCOM- 20220923
LR  - 20221204
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 279
DP  - 2022 Nov
TI  - The Role of Surgery for Primary Pulmonary Synovial Sarcoma: A Population-Based 
      Study.
PG  - 338-351
LID - S0022-4804(22)00388-2 [pii]
LID - 10.1016/j.jss.2022.06.034 [doi]
AB  - INTRODUCTION: The rarity of primary pulmonary synovial sarcoma (PPSS) and the 
      lack of prospective clinical trials resulted in poorly understood treatment 
      modality and clinical outcomes. This study aimed to better understand PPSS based 
      on patients from the Surveillance, Epidemiology, and End Results database. 
      MATERIALS AND METHODS: Clinical and survival data of PPSS patients who were 
      diagnosed during 1989 through 2016 and retrieved from the Surveillance, 
      Epidemiology, and End Results database were studied. Kaplan-Meier analyses and 
      Cox proportional hazards model were applied to evaluate the overall survival (OS) 
      and disease-specific survival (DSS) of PPSS patients. RESULTS: A total of 122 
      patients with PPSS were included (median age: 50 y). PPSS accounted for 4.5% 
      (122/2741) of total primary synovial sarcoma. Most of the patients were diagnosed 
      as poor or undifferentiated grade (52.0% and 34.0%). Cancer-directed surgery was 
      performed for 74.4% of PPSS patients and 28.2% of patients received radiotherapy. 
      The 1-year, 3-year, 5-year, and 10-year OS rates of PPSS patients were 75.4%, 
      50.8%, 41.8%, and 39.3%, respectively. Cancer-directed surgery was shown to 
      improve the survival of PPSS patients with localized or regional stage 
      (P < 0.05), yet surgical resection did not prolong the OS and DSS of patients 
      with distant stage (P > 0.1). Postoperational radiotherapy was associated with 
      shortened survival time (P < 0.05). PPSS patients who received lobectomy had 
      statistically prolonged OS and DSS than those with pneumonectomy (P < 0.001). 
      CONCLUSIONS: PPSS is a rare and special subtype of synovial sarcoma. Treatment 
      with lobectomy or sublobar resection alone may contribute to a superior prognosis 
      compared with other managements.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Chen, Xiaowei
AU  - Chen X
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, People's Republic of China; Institute of Oncology, 
      Shandong Provincial Hospital, Shandong University, Jinan, People's Republic of 
      China.
FAU - Ma, Guoyuan
AU  - Ma G
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, People's Republic of China; Institute of Oncology, 
      Shandong Provincial Hospital, Shandong University, Jinan, People's Republic of 
      China.
FAU - Zhao, Xiaogang
AU  - Zhao X
AD  - Department of Thoracic Surgery, The Second Hospital of Shandong University, 
      Jinan, People's Republic of China.
FAU - Liu, Jichang
AU  - Liu J
AD  - Institute of Oncology, Shandong Provincial Hospital, Shandong University, Jinan, 
      People's Republic of China.
FAU - Li, Jiahao
AU  - Li J
AD  - Institute of Oncology, Shandong Provincial Hospital, Shandong University, Jinan, 
      People's Republic of China.
FAU - Du, Jiajun
AU  - Du J
AD  - Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, People's Republic of China; Institute of Oncology, 
      Shandong Provincial Hospital, Shandong University, Jinan, People's Republic of 
      China; Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to 
      Shandong First Medical University, Jinan, People's Republic of China. Electronic 
      address: dujiajun@sdu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220708
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
SB  - IM
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - *Lung Neoplasms/surgery
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - SEER Program
MH  - *Sarcoma, Synovial/surgery
OTO - NOTNLM
OT  - Primary pulmonary synovial sarcoma
OT  - Prognosis
OT  - SEER
OT  - Surgery
OT  - Synovial sarcoma
EDAT- 2022/07/11 06:00
MHDA- 2022/09/24 06:00
CRDT- 2022/07/10 18:12
PHST- 2021/10/19 00:00 [received]
PHST- 2022/04/23 00:00 [revised]
PHST- 2022/06/04 00:00 [accepted]
PHST- 2022/07/11 06:00 [pubmed]
PHST- 2022/09/24 06:00 [medline]
PHST- 2022/07/10 18:12 [entrez]
AID - S0022-4804(22)00388-2 [pii]
AID - 10.1016/j.jss.2022.06.034 [doi]
PST - ppublish
SO  - J Surg Res. 2022 Nov;279:338-351. doi: 10.1016/j.jss.2022.06.034. Epub 2022 Jul 
      8.