PMID- 35810817 OWN - NLM STAT- MEDLINE DCOM- 20220830 LR - 20220928 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 214 IP - Pt 1 DP - 2022 Nov TI - Maternal short-term exposure to NO(2) during pregnancy and its relationship with Doppler markers of placental function. PG - 113813 LID - S0013-9351(22)01140-9 [pii] LID - 10.1016/j.envres.2022.113813 [doi] AB - BACKGROUND: Maternal exposure to air pollution has been associated with poor obstetric outcomes. However, the available evidence on the impact of maternal exposure to air pollution on placental function is still scarce and is based on estimated ambient levels of air pollutants. OBJECTIVE: To evaluate the association between short-term maternal exposure to NO(2) based on the objective personal measure of NO(2) exposure and Doppler markers of placental function. METHODS: This study was based on a prospective cohort of 101 pregnant women, recruited at Hospital Sant Joan de Deu, Barcelona (Spain), between January 2017 and April 2018. NO(2) diffusion tubes were worn by pregnant women to measure personal exposure to NO(2) between weeks 28 and 32 of their pregnancy. Placental function was evaluated at the 32nd week of gestation by Doppler evaluation of mean uterine arteries pulsatility index (PI), umbilical artery PI, middle cerebral artery PI, cerebroplacental ratio (CPR) and ductus venosus PI. Linear regression models were applied to estimate the association of personal NO(2) exposure and Doppler markers of placental function (one at a time), controlled for relevant covariates. RESULTS: Higher personal exposure to NO(2) was significantly associated with lower mean uterine artery PI. Each one-interquartile range (IQR) increase in the exposure to NO (2) was associated with -0.07 (95% confidence intervals (CIs): -0.12, -0.02) decrease in uterine arteries PI. We also observed some suggestions for an inverse association between this exposure and CPR. A one-IQR increase in NO(2) was associated with -0.18 (95% CIs: -0.37, 0.01) decrease in CPR. The findings for the rest of Doppler markers were not conclusive. CONCLUSIONS: Maternal exposure to NO(2) could interfere with Doppler markers of placental function, potentially indicating a certain degree of cerebral vasodilatation with a decrease of mean uterine arteries PI. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Cahuana-Bartra, Marc Josep AU - Cahuana-Bartra MJ AD - BCNatal, Barcelona Centre for Maternal Foetal and Neonatal Medicine, Hospital Sant Joan de Deu and Hospital Clinic. Universitat de Barcelona, Spain; Institut de Recerca Sant Joan de Deu (IR-SJD), 08028, Barcelona, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin, RD21/0012/0001, Instituto de Salud Carlos III, Spain. Electronic address: marc.cahuana@sjd.es. FAU - Mazarico-Gallego, Edurne AU - Mazarico-Gallego E AD - BCNatal, Barcelona Centre for Maternal Foetal and Neonatal Medicine, Hospital Sant Joan de Deu and Hospital Clinic. Universitat de Barcelona, Spain; Institut de Recerca Sant Joan de Deu (IR-SJD), 08028, Barcelona, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin, RD21/0012/0001, Instituto de Salud Carlos III, Spain. FAU - Cahuana-Bartra, Alex Joan AU - Cahuana-Bartra AJ AD - BCNatal, Barcelona Centre for Maternal Foetal and Neonatal Medicine, Hospital Sant Joan de Deu and Hospital Clinic. Universitat de Barcelona, Spain. FAU - Pascal, Rosalia AU - Pascal R AD - BCNatal, Barcelona Centre for Maternal Foetal and Neonatal Medicine, Hospital Sant Joan de Deu and Hospital Clinic. Universitat de Barcelona, Spain; Institut de Recerca Sant Joan de Deu (IR-SJD), 08028, Barcelona, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin, RD21/0012/0001, Instituto de Salud Carlos III, Spain. FAU - Alonso-Garcia, Lucia AU - Alonso-Garcia L AD - ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain. FAU - Targa, Jaume AU - Targa J AD - 4sfera Innova SL, Girona, Spain. FAU - Munoz-Lozano, Concha AU - Munoz-Lozano C AD - Institut de Recerca Sant Joan de Deu (IR-SJD), 08028, Barcelona, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin, RD21/0012/0001, Instituto de Salud Carlos III, Spain. FAU - Dadvand, Payam AU - Dadvand P AD - ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. FAU - Gomez-Roig, Maria Dolores AU - Gomez-Roig MD AD - BCNatal, Barcelona Centre for Maternal Foetal and Neonatal Medicine, Hospital Sant Joan de Deu and Hospital Clinic. Universitat de Barcelona, Spain; Institut de Recerca Sant Joan de Deu (IR-SJD), 08028, Barcelona, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin, RD21/0012/0001, Instituto de Salud Carlos III, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20220708 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - S7G510RUBH (Nitrogen Dioxide) SB - IM MH - Female MH - Humans MH - *Maternal Exposure MH - *Nitrogen Dioxide MH - Placenta MH - Pregnancy MH - Prospective Studies MH - Ultrasonography, Prenatal OTO - NOTNLM OT - Air pollution OT - Foetal growth OT - Gestation OT - Maternal-foetal Doppler OT - Nitrogen oxides OT - Personal monitoring EDAT- 2022/07/11 06:00 MHDA- 2022/08/31 06:00 CRDT- 2022/07/10 19:23 PHST- 2022/03/04 00:00 [received] PHST- 2022/06/08 00:00 [revised] PHST- 2022/06/30 00:00 [accepted] PHST- 2022/07/11 06:00 [pubmed] PHST- 2022/08/31 06:00 [medline] PHST- 2022/07/10 19:23 [entrez] AID - S0013-9351(22)01140-9 [pii] AID - 10.1016/j.envres.2022.113813 [doi] PST - ppublish SO - Environ Res. 2022 Nov;214(Pt 1):113813. doi: 10.1016/j.envres.2022.113813. Epub 2022 Jul 8.