PMID- 35812082 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 13 DP - 2022 TI - Neuropsychiatric or Behavioral and Psychological Symptoms of Dementia (BPSD): Focus on Prevalence and Natural History in Alzheimer's Disease and Frontotemporal Dementia. PG - 832199 LID - 10.3389/fneur.2022.832199 [doi] LID - 832199 AB - Neuropsychiatric or behavioral and psychological symptoms of dementia (BPSD) represent a heterogeneous group of non-cognitive symptoms that are virtually present in all patients during the course of their disease. The aim of this study is to examine the prevalence and natural history of BPSD in a large cohort of patients with behavioral variant of frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) in three stages: (i) pre-T0 (before the onset of the disease); (ii) T0 or manifested disease (from the onset to 5 years); (iii) T1 or advanced (from 5 years onwards). Six hundred seventy-four clinical records of patients with bvFTD and 1925 with AD, from 2006 to 2018, were studied. Symptoms have been extracted from Neuropsychiatric Inventory (NPI) and from a checklist of BPSD for all periods observed. In our population, BPSD affect up to 90% of all dementia subjects over the course of their illness. BPSD profiles of the two dementia groups were similar but not identical. The most represented symptoms were apathy, irritability/affective lability, and agitation/aggression. Considering the order of appearance of neuropsychiatric symptoms in AD and bvFTD, mood disorders (depression, anxiety) come first than the other BPSD, with the same prevalence. This means that they could be an important "red flag" in detection of dementia. With the increase of disease severity, aberrant motor behavior and wandering were significantly more present in both groups. Differences between BPSD in AD and bvFTD resulted only in prevalence: Systematically, in bvFTD, all the symptoms were more represented than in AD, except for hallucinations, depression, anxiety, and irritability. Given their high frequency and impact on management and overall health care resources, BPSD should not be underestimated and considered as an additional important diagnostic and therapeutic target both in patients with AD and bvFTD. CI - Copyright (c) 2022 Lagana, Bruno, Altomari, Bruni, Smirne, Curcio, Mirabelli, Colao, Puccio, Frangipane, Cupidi, Torchia, Muraca, Malvaso, Addesi, Montesanto, Di Lorenzo, Bruni and Maletta. FAU - Lagana, Valentina AU - Lagana V AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. FAU - Bruno, Francesco AU - Bruno F AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. AD - Regional Neurogenetic Centre - ASP-CZ, Lamezia Terme, Italy. FAU - Altomari, Natalia AU - Altomari N AD - Department of Mathematics and Computer Science, University of Calabria, Rende, Italy. FAU - Bruni, Giulia AU - Bruni G AD - Regional Neurogenetic Centre - ASP-CZ, Lamezia Terme, Italy. FAU - Smirne, Nicoletta AU - Smirne N AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. FAU - Curcio, Sabrina AU - Curcio S AD - Regional Neurogenetic Centre - ASP-CZ, Lamezia Terme, Italy. FAU - Mirabelli, Maria AU - Mirabelli M AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. FAU - Colao, Rosanna AU - Colao R AD - Regional Neurogenetic Centre - ASP-CZ, Lamezia Terme, Italy. FAU - Puccio, Gianfranco AU - Puccio G AD - Regional Neurogenetic Centre - ASP-CZ, Lamezia Terme, Italy. FAU - Frangipane, Francesca AU - Frangipane F AD - Regional Neurogenetic Centre - ASP-CZ, Lamezia Terme, Italy. FAU - Cupidi, Chiara AU - Cupidi C AD - Neurology Unit, Fondazione Istituto Giglio, Cefalu, Italy. FAU - Torchia, Giusy AU - Torchia G AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. FAU - Muraca, Gabriella AU - Muraca G AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. FAU - Malvaso, Antonio AU - Malvaso A AD - Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Addesi, Desiree AU - Addesi D AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. AD - Department of Internal Medicine, Pugliese Ciaccio Hospital, Catanzaro, Italy. FAU - Montesanto, Alberto AU - Montesanto A AD - Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy. FAU - Di Lorenzo, Raffaele AU - Di Lorenzo R AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. AD - Regional Neurogenetic Centre - ASP-CZ, Lamezia Terme, Italy. FAU - Bruni, Amalia Cecilia AU - Bruni AC AD - Association for Neurogenetic Research (ARN), Lamezia Terme, Italy. FAU - Maletta, Raffaele AU - Maletta R AD - Regional Neurogenetic Centre - ASP-CZ, Lamezia Terme, Italy. LA - eng PT - Journal Article DEP - 20220624 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC9263122 OTO - NOTNLM OT - Alzheimer's disease OT - BPSD OT - behavioral and psychological symptoms of dementia OT - frontotemporal dementia OT - natural history OT - neuropsychiatric profile OT - prevalence OT - psychotic symptoms COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/07/12 06:00 MHDA- 2022/07/12 06:01 PMCR- 2022/06/24 CRDT- 2022/07/11 03:42 PHST- 2021/12/15 00:00 [received] PHST- 2022/05/02 00:00 [accepted] PHST- 2022/07/11 03:42 [entrez] PHST- 2022/07/12 06:00 [pubmed] PHST- 2022/07/12 06:01 [medline] PHST- 2022/06/24 00:00 [pmc-release] AID - 10.3389/fneur.2022.832199 [doi] PST - epublish SO - Front Neurol. 2022 Jun 24;13:832199. doi: 10.3389/fneur.2022.832199. eCollection 2022.