PMID- 35812223
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Multiple-Network Alterations in Major Depressive Disorder With Gastrointestinal 
      Symptoms at Rest Revealed by Global Functional Connectivity Analysis.
PG  - 897707
LID - 10.3389/fnins.2022.897707 [doi]
LID - 897707
AB  - OBJECTIVE: Gastrointestinal (GI) symptoms are prominent in major depressive 
      disorder (MDD) and bring patients lots of complaints and troubles. We aimed to 
      explore whether there were some distinctive brain image alterations in MDD with 
      GI symptoms, which could be used to distinguish MDD with GI symptoms from those 
      without GI symptoms and healthy controls (HCs). METHODS: A total of 35 
      outpatients with GI symptoms, 17 outpatients without GI symptoms, and 28 HCs were 
      recruited. All the participants were scanned by a resting-state functional 
      magnetic resonance imaging. Imaging data were analyzed with the global functional 
      connectivity (GFC) and support vector machine methods. RESULTS: MDD with GI 
      symptoms showed decreased GFC in the left superior medial prefrontal cortex 
      (MPFC) compared with MDD without GI symptoms. Compared with HCs, MDD with GI 
      symptoms showed decreased GFC in the bilateral middle temporal pole (MTP) and 
      left posterior cingulate cortex/precuneus (PCC/Pcu), and increased GFC in the 
      right insula and bilateral thalamus. SVM analysis showed that an accuracy was 
      78.85% in differentiating MDD with GI symptoms from MDD without GI symptoms by 
      using the GFC of the left superior MPFC. A combination of GFC of the left PCC/Pcu 
      and bilateral MTP exhibited the highest accuracy (87.30%) in differentiating 
      patients with MDD with GI symptoms from HCs. CONCLUSION: MDD with GI symptoms 
      showed abnormal GFC in multiple networks, including the default mode network and 
      cortico-limbic mood-regulating circuit. Using abnormal GFC might work well to 
      discriminate MDD with GI symptoms from MDD without GI symptoms and HCs.
CI  - Copyright (c) 2022 Yan, Fu, Ou, Liu, Li and Guo.
FAU - Yan, Meiqi
AU  - Yan M
AD  - Department of Psychiatry and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      China.
FAU - Fu, Xiaoya
AU  - Fu X
AD  - Department of Psychiatry and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      China.
FAU - Ou, Yangpan
AU  - Ou Y
AD  - Department of Psychiatry and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      China.
FAU - Liu, Feng
AU  - Liu F
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Li, Huabing
AU  - Li H
AD  - Department of Radiology, The Second Xiangya Hospital of Central South University, 
      Changsha, China.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Department of Psychiatry and National Clinical Research Center for Mental 
      Disorders, The Second Xiangya Hospital of Central South University, Changsha, 
      China.
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
AD  - Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, China.
LA  - eng
PT  - Journal Article
DEP - 20220624
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9263397
OTO - NOTNLM
OT  - functional magnetic resonance imaging
OT  - gastrointestinal symptoms
OT  - global functional connectivity
OT  - major depressive disorder
OT  - resting state
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/12 06:00
MHDA- 2022/07/12 06:01
PMCR- 2022/01/01
CRDT- 2022/07/11 03:44
PHST- 2022/03/31 00:00 [received]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/07/11 03:44 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/12 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.897707 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Jun 24;16:897707. doi: 10.3389/fnins.2022.897707. 
      eCollection 2022.