PMID- 35812512
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20230315
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 10
DP  - 2022
TI  - Direct Medical Costs of Tetanus, Dengue, and Sepsis Patients in an Intensive Care 
      Unit in Vietnam.
PG  - 893200
LID - 10.3389/fpubh.2022.893200 [doi]
LID - 893200
AB  - BACKGROUND: Critically ill patients often require complex clinical care by highly 
      trained staff within a specialized intensive care unit (ICU) with advanced 
      equipment. There are currently limited data on the costs of critical care in 
      low-and middle-income countries (LMICs). This study aims to investigate the 
      direct-medical costs of key infectious disease (tetanus, sepsis, and dengue) 
      patients admitted to ICU in a hospital in Ho Chi Minh City (HCMC), Vietnam, and 
      explores how the costs and cost drivers can vary between the different diseases. 
      METHODS: We calculated the direct medical costs for patients requiring critical 
      care for tetanus, dengue and sepsis. Costing data (stratified into different cost 
      categories) were extracted from the bills of patients hospitalized to the adult 
      ICU with a dengue, sepsis and tetanus diagnosis that were enrolled in three 
      studies conducted at the Hospital for Tropical Diseases in HCMC from January 2017 
      to December 2019. The costs were considered from the health sector perspective. 
      The total sample size in this study was 342 patients. RESULTS: ICU care was 
      associated with significant direct medical costs. For patients that did not 
      require mechanical ventilation, the median total ICU cost per patient varied 
      between US$64.40 and US$675 for the different diseases. The costs were higher for 
      patients that required mechanical ventilation, with the median total ICU cost per 
      patient for the different diseases varying between US$2,590 and US$4,250. The 
      main cost drivers varied according to disease and associated severity. 
      CONCLUSION: This study demonstrates the notable cost of ICU care in Vietnam and 
      in similar LMIC settings. Future studies are needed to further evaluate the costs 
      and economic burden incurred by ICU patients. The data also highlight the 
      importance of evaluating novel critical care interventions that could reduce the 
      costs of ICU care.
CI  - Copyright (c) 2022 Hung, Van Hao, Yen, McBride, Dat, van Doorn, Loan, Phong, 
      Llewelyn, Nadjm, Yacoub, Thwaites, Ahmed, Van Vinh Chau, Turner and the Vietnam 
      ICU Translational Applications Laboratory (VITAL) Investigators.
FAU - Hung, Trinh Manh
AU  - Hung TM
AD  - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas 
      Programme, Ho Chi Minh City, Vietnam.
FAU - Van Hao, Nguyen
AU  - Van Hao N
AD  - Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
AD  - Department of Infectious Diseases, University of Medicine and Pharmacy, Ho Chi 
      Minh City, Vietnam.
FAU - Yen, Lam Minh
AU  - Yen LM
AD  - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas 
      Programme, Ho Chi Minh City, Vietnam.
FAU - McBride, Angela
AU  - McBride A
AD  - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas 
      Programme, Ho Chi Minh City, Vietnam.
AD  - Department of Global Health and Infection, Brighton and Sussex Medical School, 
      Brighton, United Kingdom.
FAU - Dat, Vu Quoc
AU  - Dat VQ
AD  - Department of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam.
FAU - van Doorn, H Rogier
AU  - van Doorn HR
AD  - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas 
      Programme, Hanoi, Vietnam.
AD  - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, 
      University of Oxford, Oxford, United Kingdom.
FAU - Loan, Huynh Thi
AU  - Loan HT
AD  - Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
FAU - Phong, Nguyen Thanh
AU  - Phong NT
AD  - Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
FAU - Llewelyn, Martin J
AU  - Llewelyn MJ
AD  - Department of Global Health and Infection, Brighton and Sussex Medical School, 
      Brighton, United Kingdom.
FAU - Nadjm, Behzad
AU  - Nadjm B
AD  - Medical Research Council (MRC) Unit the Gambia at the London School of Hygiene & 
      Tropical Medicine, Fajara, Gambia.
FAU - Yacoub, Sophie
AU  - Yacoub S
AD  - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas 
      Programme, Ho Chi Minh City, Vietnam.
AD  - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, 
      University of Oxford, Oxford, United Kingdom.
FAU - Thwaites, C Louise
AU  - Thwaites CL
AD  - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas 
      Programme, Ho Chi Minh City, Vietnam.
AD  - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, 
      University of Oxford, Oxford, United Kingdom.
FAU - Ahmed, Sayem
AU  - Ahmed S
AD  - Oxford University Clinical Research Unit, Wellcome Trust Major Overseas 
      Programme, Ho Chi Minh City, Vietnam.
AD  - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, 
      University of Oxford, Oxford, United Kingdom.
FAU - Van Vinh Chau, Nguyen
AU  - Van Vinh Chau N
AD  - Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
FAU - Turner, Hugo C
AU  - Turner HC
AD  - MRC Centre for Global Infectious Disease Analysis, School of Public Health, 
      Imperial College London, Norfolk Place, London, United Kingdom.
CN  - Vietnam ICU Translational Applications Laboratory (VITAL) Investigators
LA  - eng
GR  - 107367/Z/15/Z/WT_/Wellcome Trust/United Kingdom
GR  - 203905/Z/16/Z/WT_/Wellcome Trust/United Kingdom
GR  - 217650/Z/19/Z/WT_/Wellcome Trust/United Kingdom
GR  - MR/R015600/1/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_00031/7/MRC_/Medical Research Council/United Kingdom
GR  - 106680/B/14/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220620
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
SB  - IM
MH  - Adult
MH  - *Cross Infection
MH  - *Dengue/therapy
MH  - Humans
MH  - Intensive Care Units
MH  - *Sepsis/therapy
MH  - *Tetanus/therapy
MH  - Vietnam
PMC - PMC9263973
OTO - NOTNLM
OT  - ICU
OT  - Vietnam
OT  - dengue
OT  - direct medical cost
OT  - sepsis
OT  - tetanus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
FIR - Thao, Dang Phuong
IR  - Thao DP
FIR - Kien, Dang Trung
IR  - Kien DT
FIR - Thy, Doan Bui Xuan
IR  - Thy DBX
FIR - Trinh, Dong Huu Khanh
IR  - Trinh DHK
FIR - Duc, Du Hong
IR  - Duc DH
FIR - Geskus, Ronald
IR  - Geskus R
FIR - Hai, Ho Bich
IR  - Hai HB
FIR - Chanh, Ho Quang
IR  - Chanh HQ
FIR - Hien, Ho Van
IR  - Hien HV
FIR - Trieu, Huynh Trung
IR  - Trieu HT
FIR - Kestelyn, Evelyne
IR  - Kestelyn E
FIR - Khoa, Le Dinh Van
IR  - Khoa LDV
FIR - Phuong, Le Thanh
IR  - Phuong LT
FIR - Tran, Luu Hoai Bao
IR  - Tran LHB
FIR - An, Luu Phuoc
IR  - An LP
FIR - Mcbride, Angela
IR  - Mcbride A
FIR - Vuong, Nguyen Lam
IR  - Vuong NL
FIR - Huy, Nguyen Quang
IR  - Huy NQ
FIR - Quyen, Nguyen Than Ha
IR  - Quyen NTH
FIR - Ngoc, Nguyen Thanh
IR  - Ngoc NT
FIR - Giang, Nguyen Thi
IR  - Giang NT
FIR - Thanh, Nguyen Thi Le
IR  - Thanh NTL
FIR - Dung, Nguyen Thi Phuong
IR  - Dung NTP
FIR - Thao, Nguyen Thi Phuong
IR  - Thao NTP
FIR - Van, Ninh Thi Thanh
IR  - Van NTT
FIR - Khanh, Phan Nguyen Quoc
IR  - Khanh PNQ
FIR - Lam, Phung Khanh
IR  - Lam PK
FIR - Nhat, Phung Tran Huy
IR  - Nhat PTH
FIR - Thwaites, Guy
IR  - Thwaites G
FIR - Duc, Tran Minh
IR  - Duc TM
FIR - Nuil, Jennifer Ilo Van
IR  - Nuil JIV
FIR - Huyen, Vu Ngo Thanh
IR  - Huyen VNT
FIR - Tam, Cao Thi
IR  - Tam CT
FIR - Thuy, Duong Bich
IR  - Thuy DB
FIR - Duong, Ha Thi Hai
IR  - Duong HTH
FIR - Nghia, Ho Dang Trung
IR  - Nghia HDT
FIR - Chau, Le Buu
IR  - Chau LB
FIR - Toan, Le Mau
IR  - Toan LM
FIR - Thu, Le Ngoc Minh
IR  - Thu LNM
FIR - Thao, Le Thi Mai
IR  - Thao LTM
FIR - Tai, Luong Thi Hue
IR  - Tai LTH
FIR - Phu, Nguyen Hoan
IR  - Phu NH
FIR - Viet, Nguyen Quoc
IR  - Viet NQ
FIR - Nguyen, Nguyen Thanh
IR  - Nguyen NT
FIR - Anh, Nguyen Thi Kim
IR  - Anh NTK
FIR - Duoc, Nguyen Van Thanh
IR  - Duoc NVT
FIR - Oanh, Pham Kieu Nguyet
IR  - Oanh PKN
FIR - Van, Phan Thi Hong
IR  - Van PTH
FIR - Qui, Phan Tu
IR  - Qui PT
FIR - Tho, Phan Vinh
IR  - Tho PV
FIR - Thao, Truong Thi Phuong
IR  - Thao TTP
FIR - Ali, Natasha
IR  - Ali N
FIR - Clifton, David
IR  - Clifton D
FIR - English, Mike
IR  - English M
FIR - Ghiasi, Shadi
IR  - Ghiasi S
FIR - Greeff, Heloise
IR  - Greeff H
FIR - Hagenah, Jannis
IR  - Hagenah J
FIR - Lu, Ping
IR  - Lu P
FIR - McKnight, Jacob
IR  - McKnight J
FIR - Paton, Chris
IR  - Paton C
FIR - Georgiou, Pantelis
IR  - Georgiou P
FIR - Perez, Bernard Hernandez
IR  - Perez BH
FIR - Hill-Cawthorne, Kerri
IR  - Hill-Cawthorne K
FIR - Holmes, Alison
IR  - Holmes A
FIR - Karolcik, Stefan
IR  - Karolcik S
FIR - Ming, Damien
IR  - Ming D
FIR - Moser, Nicolas
IR  - Moser N
FIR - Canas, Liane
IR  - Canas L
FIR - Gomez, Alberto
IR  - Gomez A
FIR - Kerdegari, Hamideh
IR  - Kerdegari H
FIR - Modat, Marc
IR  - Modat M
FIR - Razavi, Reza
IR  - Razavi R
FIR - Denehy, Linda
IR  - Denehy L
FIR - Pisani, Luigi
IR  - Pisani L
FIR - Schultz, Marcus
IR  - Schultz M
EDAT- 2022/07/12 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/06/20
CRDT- 2022/07/11 03:48
PHST- 2022/03/10 00:00 [received]
PHST- 2022/05/13 00:00 [accepted]
PHST- 2022/07/11 03:48 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/06/20 00:00 [pmc-release]
AID - 10.3389/fpubh.2022.893200 [doi]
PST - epublish
SO  - Front Public Health. 2022 Jun 20;10:893200. doi: 10.3389/fpubh.2022.893200. 
      eCollection 2022.