PMID- 35812677
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 10
IP  - 16
DP  - 2022 Jun 6
TI  - Ovarian teratoma related anti-N-methyl-D-aspartate receptor encephalitis: A case 
      series and review of the literature.
PG  - 5196-5207
LID - 10.12998/wjcc.v10.i16.5196 [doi]
AB  - BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare but 
      important complication of ovarian teratoma. Between July 2012 and December 2019, 
      six patients with ovarian teratoma-associated anti-NMDAR encephalitis were 
      enrolled in our hospital and their clinical characteristics, treatment, and 
      follow-up were reviewed. We also conducted a systematic literature review of 
      ovarian teratoma related anti-NMDAR encephalitis reports between January 2014 and 
      December 2019. AIM: To better understand anti-NMDAR encephalitis through 
      literature review and patients enrolled in our hospital. METHODS: The six 
      patients enrolled in the study were those diagnosed with anti-NMDAR encephalitis. 
      Their history, clinical manifestations, and medications were recorded and optimum 
      treatment provided in addition to maintaining a record of the follow-ups. In 
      addition, we also extensively surveyed the literature and provide summarized data 
      from 155 published cases of anti-NMDAR encephalitis from 130 case reports. PubMed 
      and Scopus were the sources of these publications and the time period covered was 
      6 years ranging from January 2014 through December 2019. RESULTS: The six 
      patients enrolled for this study presented with typical symptoms resulting in a 
      diagnosis of ovarian teratoma induced anti-NMDAR encephalitis. Appropriate 
      interventions led to a positive outcome in all the patients, with five of six 
      patients reporting full recovery and the sixth patient recovering with a few 
      deficits. No death was recorded. The literature survey comprising of 155 patients 
      cases across 130 case reports of anti-NMDAR encephalitis clearly indicated an 
      upward trend in the reports/diagnosis in China, particularly in the surveyed time 
      from 2014 through 2019. The majority of patients (150/155) underwent surgical 
      intervention resulting in positive outcome. No treatment intervention was 
      mentioned for one case while the four patients who were not surgically operated 
      succumbed to the disease. CONCLUSION: Suspected anti-NMDAR encephalitis should be 
      quickly evaluated for anti-NMDAR antibodies since early diagnosis is important. 
      In case of a tumor, its earliest and complete removal is recommended. Finally, 
      early use of corticosteroids and IgG-depleting strategies (intravenous 
      immunoglobulin or plasma exchange) may improve outcome.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Li, Shan-Ji
AU  - Li SJ
AD  - Department of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200127, China.
FAU - Yu, Min-Hua
AU  - Yu MH
AD  - Department of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200127, China.
FAU - Cheng, Jie
AU  - Cheng J
AD  - Center for Reproductive Medicine, Shanghai Jiao Tong University, Shanghai 200135, 
      China.
FAU - Bai, Wen-Xin
AU  - Bai WX
AD  - Department of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
FAU - Di, Wen
AU  - Di W
AD  - Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai 200127, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC9210914
OTO - NOTNLM
OT  - Anti-N-methyl-D-aspartate receptor encephalitis
OT  - Immunotherapy
OT  - Ovarian teratoma
OT  - Surgery
COIS- Conflict-of-interest statement: None of the authors have any conflict of interest 
      to report.
EDAT- 2022/07/12 06:00
MHDA- 2022/07/12 06:01
PMCR- 2022/06/06
CRDT- 2022/07/11 03:49
PHST- 2021/07/12 00:00 [received]
PHST- 2021/08/15 00:00 [revised]
PHST- 2022/04/09 00:00 [accepted]
PHST- 2022/07/11 03:49 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/12 06:01 [medline]
PHST- 2022/06/06 00:00 [pmc-release]
AID - 10.12998/wjcc.v10.i16.5196 [doi]
PST - ppublish
SO  - World J Clin Cases. 2022 Jun 6;10(16):5196-5207. doi: 10.12998/wjcc.v10.i16.5196.