PMID- 35812821 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240220 IS - 2451-8654 (Electronic) IS - 2451-8654 (Linking) VI - 28 DP - 2022 Aug TI - Protocol for mindfulness-oriented recovery enhancement (MORE) in the management of lumbosacral radiculopathy/radiculitis symptoms: A randomized controlled trial. PG - 100962 LID - 10.1016/j.conctc.2022.100962 [doi] LID - 100962 AB - INTRODUCTION: Lumbosacral radiculopathy/radiculitis (LR) or "sciatica" is a commonly intractable sequelae of chronic low back pain (LBP), and challenges in the treatment of LR indicate that persistent pain may have both mechanical and neuropathic origins. Mindfulness-based interventions have been demonstrated to be effective tools in mitigating self-reported pain in LBP patients. This paper describes the protocol for a randomized controlled trial (RCT) evaluating the effects of the specific mindfulness-based intervention Mindfulness-Oriented Recovery Enhancement (MORE) on LR symptoms and sequelae, including mental health and physical function. METHODS: Participants recruited from the Portland, OR area are screened before completing a baseline visit that includes a series of self-report questionnaires and surface electromyography (sEMG) of the lower extremity. Upon enrollment, participants are randomly assigned to the MORE (experimental) group or treatment as usual (control) group for 8 weeks. Self-reported assessments and sEMG studies are repeated after the intervention is complete for pre/post-intervention comparisons. The outcome measures evaluate self-reported pain, physical function, quality of life, depression symptoms, trait mindfulness, and reinterpretation of pain, with surface electromyography (sEMG) findings evaluating objective physical function in patients with LR. To our knowledge, this is the first trial to date using an objective measure, sEMG, to evaluate the effects of a mindfulness-based intervention on LR symptoms. HYPOTHESES: We hypothesize that MORE will be effective in improving self-reported pain, physical function, quality of life, depression symptoms, mindfulness, and reinterpretation of pain scores after 8 weeks of mindfulness training as compared to treatment as usual. Additionally, we hypothesize that individuals in the MORE group with abnormal sEMG findings at baseline will have improved sEMG findings at their 8-week follow-up visit. CI - (c) 2022 The Authors. Published by Elsevier Inc. FAU - Wexler, Ryan S AU - Wexler RS AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Fox, Devon J AU - Fox DJ AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Edmond, Hannah AU - Edmond H AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Lemau, Johnny AU - Lemau J AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - ZuZero, Danielle AU - ZuZero D AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Bollen, Melissa AU - Bollen M AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Montenegro, Diane AU - Montenegro D AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Parikshak, Anand AU - Parikshak A AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Thompson, Austin R AU - Thompson AR AD - Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. FAU - Carlson, Nels L AU - Carlson NL AD - Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. FAU - Carlson, Hans L AU - Carlson HL AD - Department of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA. FAU - Wentz, Anna E AU - Wentz AE AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Bradley, Ryan AU - Bradley R AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. AD - Herbert Wertheim School of Public Health and Human Longevity Sciences, University of California, San Diego, La Jolla, CA, USA. FAU - Hanes, Douglas A AU - Hanes DA AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Zwickey, Heather AU - Zwickey H AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. FAU - Pickworth, Courtney K AU - Pickworth CK AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. LA - eng GR - K24 AT011568/AT/NCCIH NIH HHS/United States GR - R90 AT008924/AT/NCCIH NIH HHS/United States PT - Journal Article DEP - 20220703 PL - Netherlands TA - Contemp Clin Trials Commun JT - Contemporary clinical trials communications JID - 101671157 PMC - PMC9260614 OTO - NOTNLM OT - Low back pain OT - Lumbosacral radiculopathy OT - Mindfulness OT - Mindfulness-oriented recovery enhancement OT - RCT protocol OT - Virtual intervention COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/07/12 06:00 MHDA- 2022/07/12 06:01 PMCR- 2022/07/03 CRDT- 2022/07/11 03:52 PHST- 2022/02/01 00:00 [received] PHST- 2022/06/22 00:00 [revised] PHST- 2022/06/27 00:00 [accepted] PHST- 2022/07/11 03:52 [entrez] PHST- 2022/07/12 06:00 [pubmed] PHST- 2022/07/12 06:01 [medline] PHST- 2022/07/03 00:00 [pmc-release] AID - S2451-8654(22)00079-5 [pii] AID - 100962 [pii] AID - 10.1016/j.conctc.2022.100962 [doi] PST - epublish SO - Contemp Clin Trials Commun. 2022 Jul 3;28:100962. doi: 10.1016/j.conctc.2022.100962. eCollection 2022 Aug.