PMID- 35813190
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2040-6223 (Print)
IS  - 2040-6231 (Electronic)
IS  - 2040-6223 (Linking)
VI  - 13
DP  - 2022
TI  - Association between thyroid hormones and skeletal muscle and bone in euthyroid 
      type 2 diabetes patients.
PG  - 20406223221107848
LID - 10.1177/20406223221107848 [doi]
LID - 20406223221107848
AB  - BACKGROUND: The impact of thyroid hormones within their normal ranges on skeletal 
      muscle and bone in patients with type 2 diabetes mellitus (T2DM) remains unknown. 
      The purpose of this study was to investigate the relationships of thyroid 
      hormones with muscle and bone in euthyroid patients with T2DM. METHODS: This 
      cross-sectional study included 344 euthyroid T2DM patients. Muscle mass and bone 
      mineral density were measured by dual-energy X-ray absorptiometry. The levels of 
      thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxin 
      (FT4) were measured by electrochemiluminescence immunoassay. RESULTS: The results 
      revealed that FT3 was positively correlated with body mass index (BMI) in male 
      patients after age correction. In men, FT4 was negatively correlated with body 
      weight, BMI, total muscle mass, appendicular skeletal muscle mass (ASM), and ASM 
      index (ASMI), while FT3/FT4 was positively correlated with body weight, BMI, 
      total muscle mass, ASM, and ASMI after age correction. In women, FT4 was 
      negatively correlated with ASM and ASMI, while FT3/FT4 was positively correlated 
      with ASM and ASMI after age correction. FT3/FT4 was significantly lower in men 
      with low muscle mass than in those with normal muscle mass. The age-adjusted odds 
      for incident low muscle mass comparing the lowest and highest FT3/FT4 increased 
      in men. CONCLUSIONS: FT3/FT4 was positively correlated with ASM and ASMI in both 
      men and women. Therefore, FT3/FT4 may be a parameter indicative of low muscle 
      mass in euthyroid men with T2DM.
CI  - (c) The Author(s), 2022.
FAU - Fang, Ling-Na
AU  - Fang LN
AUID- ORCID: 0000-0002-4540-2631
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Zhong, Shao
AU  - Zhong S
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Ma, Dan
AU  - Ma D
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Hao, Yan-Min
AU  - Hao YM
AD  - Department of Orthopaedics, Kunshan Hospital Affiliated with Jiangsu University, 
      Kunshan, China.
FAU - Gao, Yan
AU  - Gao Y
AD  - Department of Orthopaedics, Kunshan Hospital Affiliated with Jiangsu University, 
      Kunshan, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Shen, Li-Wen
AU  - Shen LW
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Sun, He-Ping
AU  - Sun HP
AD  - Department of Endocrinology and Metabolism, Kunshan Hospital Affiliated with 
      Jiangsu University, Kunshan, China.
FAU - Lu, Ke
AU  - Lu K
AUID- ORCID: 0000-0002-0029-7874
AD  - Department of Orthopaedics, Kunshan Hospital Affiliated with Jiangsu University, 
      Kunshan, China.
FAU - Li, Chong
AU  - Li C
AD  - Department of Orthopaedics, Kunshan Hospital Affiliated with Jiangsu University, 
      Qianjin road 91#, Kunshan, Jiangsu, 215300, China(mainland).
LA  - eng
PT  - Journal Article
DEP - 20220704
PL  - United States
TA  - Ther Adv Chronic Dis
JT  - Therapeutic advances in chronic disease
JID - 101532140
PMC - PMC9260573
OTO - NOTNLM
OT  - bone
OT  - skeletal muscle
OT  - thyroid hormone
OT  - type 2 diabetes mellitus
COIS- Conflict of interest statement: The authors declared no potential conflicts of 
      interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2022/07/12 06:00
MHDA- 2022/07/12 06:01
PMCR- 2022/07/04
CRDT- 2022/07/11 03:58
PHST- 2022/02/11 00:00 [received]
PHST- 2022/06/01 00:00 [accepted]
PHST- 2022/07/11 03:58 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/12 06:01 [medline]
PHST- 2022/07/04 00:00 [pmc-release]
AID - 10.1177_20406223221107848 [pii]
AID - 10.1177/20406223221107848 [doi]
PST - epublish
SO  - Ther Adv Chronic Dis. 2022 Jul 4;13:20406223221107848. doi: 
      10.1177/20406223221107848. eCollection 2022.