PMID- 35813442
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20231214
IS  - 1748-6718 (Electronic)
IS  - 1748-670X (Print)
IS  - 1748-670X (Linking)
VI  - 2022
DP  - 2022
TI  - Effects of Plasma Exchange Combined with Immunoglobulin Therapy on Consciousness, 
      Immune Function, and Prognosis in Patients with Myasthenia Gravis Crisis: A 
      Prospective Randomized Test.
PG  - 7796833
LID - 10.1155/2022/7796833 [doi]
LID - 7796833
AB  - BACKGROUND: Myasthenia gravis (MG) is an acquired autoimmune disease. The main 
      clinical features of MG are skeletal muscle fatigue and pathological fatigue, 
      which worsen at night or after fatigue, such as dyspnea, dysphagia, and systemic 
      weakness. Plasma exchange (PE) is often used in patients with acute exacerbation 
      of MG. Intravenous immunoglobulin (IVIG) is a collection of immunoglobulins from 
      thousands of donors. IVIG can replace a variety of immunosuppressants or PE. 
      However, the effect of PE or IVIG on patients' consciousness, immune function, 
      and prognosis is not clear. OBJECTIVE: A prospective randomized test of the 
      effects of PE combined with immunoglobulin on consciousness, immune function, and 
      prognosis in patients with myasthenia gravis crisis (MGC). METHODS: Sixty 
      patients with MGC treated from February 2019 to April 2021 were enrolled in our 
      hospital. The cases who received PE were set as the PE group, and those who 
      received PE combined with immunoglobulin were set as the PE+immunoglobulin group. 
      The efficacy, clinical score, state of consciousness, immune function, 
      acetylcholine receptor antibody (AChR-Ab), lymphocyte (LYM), albumin (ALB) 
      levels, and the incidence of adverse reactions were compared. RESULTS: The 
      improvement rate was 100.005% in the treatment group and 83.33% in the PE group. 
      After treatment, the clinical score of the PE+immunoglobulin group was lower than 
      that of the PE group, and the clinical relative score of the PE+immunoglobulin 
      group was higher than that of the PE group (P < 0.05). The number of conscious 
      people in the PE+immunoglobulin group was more than that in the PE group (P < 
      0.05). Immunoglobulin A, immunoglobulin M, immunoglobulin G, and immunoglobulin G 
      in the PE+immunoglobulin group were higher than those in the PE group (P < 0.05). 
      The levels of AChR-Ab and ALB in the PE+immunoglobulin group were higher than 
      those in the PE group, while the level of LYM in the PE+immunoglobulin group was 
      lower than that in the PE group. The incidence of skin system, gastrointestinal 
      system, nervous system, and systemic damage in the PE+immunoglobulin group was 
      lower than that in the PE group (P < 0.05). CONCLUSION: The treatment of MGC with 
      PE combined with immunoglobulin can not only effectively enhance the 
      consciousness and immune function of patients but also effectively promote the 
      prognosis, and the safety of treatment can be guaranteed.
CI  - Copyright (c) 2022 Xu Peng et al.
FAU - Peng, Xu
AU  - Peng X
AUID- ORCID: 0000-0001-9493-993X
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
FAU - Xie, Xiao-Bi
AU  - Xie XB
AD  - Department of Cardiology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
FAU - Tan, Hong
AU  - Tan H
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
FAU - Zhang, Dan
AU  - Zhang D
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
FAU - Jiang, Bo-Tao
AU  - Jiang BT
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
FAU - Li, Shuang
AU  - Li S
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
FAU - Chen, Ya-Rui
AU  - Chen YR
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
FAU - Xie, Tao-Yang
AU  - Xie TY
AD  - Department of Neurology, The First Hospital of Changsha, Changsha, Hunan 410005, 
      China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Retracted Publication
DEP - 20220630
PL  - United States
TA  - Comput Math Methods Med
JT  - Computational and mathematical methods in medicine
JID - 101277751
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
RIN - Comput Math Methods Med. 2023 Dec 6;2023:9786520. PMID: 38094453
MH  - Consciousness
MH  - Humans
MH  - Immunity
MH  - Immunization, Passive
MH  - Immunoglobulin G
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - *Myasthenia Gravis/therapy
MH  - *Plasma Exchange
MH  - Prognosis
MH  - Prospective Studies
PMC - PMC9262518
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/07/12 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/06/30
CRDT- 2022/07/11 04:01
PHST- 2022/05/06 00:00 [received]
PHST- 2022/05/30 00:00 [revised]
PHST- 2022/06/09 00:00 [accepted]
PHST- 2022/07/11 04:01 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/06/30 00:00 [pmc-release]
AID - 10.1155/2022/7796833 [doi]
PST - epublish
SO  - Comput Math Methods Med. 2022 Jun 30;2022:7796833. doi: 10.1155/2022/7796833. 
      eCollection 2022.