PMID- 35813446
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1687-708X (Print)
IS  - 1687-7098 (Electronic)
IS  - 1687-708X (Linking)
VI  - 2022
DP  - 2022
TI  - Investigating the Antimicrobial Activity of Vancomycin-Loaded Soy Protein 
      Nanoparticles.
PG  - 5709999
LID - 10.1155/2022/5709999 [doi]
LID - 5709999
AB  - Developing targeted and slow-release antibiotic delivery systems can effectively 
      reduce drug overdose and side effects. This study aimed to investigate the 
      antimicrobial activity of vancomycin-loaded soy protein nanoparticles 
      (vancomycin-SPNs). For the preparation of SPNs, the desolvation method was 
      applied in different concentrations of vancomycin and soy protein (15:5, 10:15, 
      6:20, 8:25, and 10:30 of vancomycin:soy protein). Scanning electron microscope 
      (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), 
      and FTIR were used for nanoparticle characterization. Antibacterial activity was 
      evaluated by the radial diffusion assay (RDA) and absorbance methods. Proper 
      synthesis was demonstrated by characterization. The best drug loading (% 
      entrapment efficiency = 90.2%), the fastest release rate (% release = 88.2%), and 
      the best antibacterial activity were observed in ratio 10:30 of vancomycin:SPNs. 
      Results showed that SPNs are a potent delivery system for antibiotic loading and 
      slow release to control antibiotic use.
CI  - Copyright (c) 2022 Hadi Zare-Zardini et al.
FAU - Zare-Zardini, Hadi
AU  - Zare-Zardini H
AUID- ORCID: 0000-0002-1501-2560
AD  - Department of Biomedical Engineering, Meybod University, Meybod, Iran.
AD  - Hematology and Oncology Research Center, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
AD  - Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive 
      Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
FAU - Soltaninejad, Hossein
AU  - Soltaninejad H
AUID- ORCID: 0000-0003-4813-4924
AD  - Faculty of Interdisciplinary Science and Technology, Tarbiat Modares University, 
      Tehran, Iran.
FAU - Ghorani-Azam, Adel
AU  - Ghorani-Azam A
AUID- ORCID: 0000-0003-4374-4619
AD  - Department of Forensic Medicine and Toxicology, School of Medicine, Urmia 
      University of Medical Sciences, Urmia, Iran.
FAU - Forouzani-Moghaddam, Mohammad Javad
AU  - Forouzani-Moghaddam MJ
AUID- ORCID: 0000-0002-1234-2054
AD  - School of Paramedical, Iran University of Medical Sciences, Tehran, Iran.
FAU - Mozafri, Sima
AU  - Mozafri S
AUID- ORCID: 0000-0003-4960-2718
AD  - Hematology and Oncology Research Center, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
FAU - Akhoundi-Meybodi, Zohreh
AU  - Akhoundi-Meybodi Z
AUID- ORCID: 0000-0002-8761-9388
AD  - Hematology and Oncology Research Center, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
FAU - Ferdosian, Farzad
AU  - Ferdosian F
AUID- ORCID: 0000-0002-2763-7859
AD  - Hematology and Oncology Research Center, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
FAU - Jabinian, Fatemeh
AU  - Jabinian F
AUID- ORCID: 0000-0002-5783-890X
AD  - Department of Operating Room and Anesthesiology, School of Allied Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220629
PL  - Egypt
TA  - Interdiscip Perspect Infect Dis
JT  - Interdisciplinary perspectives on infectious diseases
JID - 101496545
PMC - PMC9259352
COIS- The authors declare no conflicts of interest that are relevant to the content of 
      this article.
EDAT- 2022/07/12 06:00
MHDA- 2022/07/12 06:01
PMCR- 2022/06/29
CRDT- 2022/07/11 04:01
PHST- 2022/03/17 00:00 [received]
PHST- 2022/05/30 00:00 [revised]
PHST- 2022/06/14 00:00 [accepted]
PHST- 2022/07/11 04:01 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/12 06:01 [medline]
PHST- 2022/06/29 00:00 [pmc-release]
AID - 10.1155/2022/5709999 [doi]
PST - epublish
SO  - Interdiscip Perspect Infect Dis. 2022 Jun 29;2022:5709999. doi: 
      10.1155/2022/5709999. eCollection 2022.