PMID- 35813663
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20221207
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - The Role of Slit-2 in Gestational Diabetes Mellitus and Its Effect on Pregnancy 
      Outcome.
PG  - 889505
LID - 10.3389/fendo.2022.889505 [doi]
LID - 889505
AB  - BACKGROUND: Slit guidance ligand 2 (Slit-2), as a member of the Slit family, can 
      regulate the inflammatory response and glucose metabolism. The purpose of this 
      study was to explore the expression of Slit-2 in maternal peripheral blood and 
      neonatal cord blood of gestational diabetes mellitus (GDM) patients and its 
      potential importance in disease progression. METHODS: This study included 57 
      healthy pregnant women and 61 GDM patients. The levels of Slit-2, C-reactive 
      protein (CRP), monocyte chemoattractant protein-1 (MCP-1), C-peptide (C-P), 
      galectin-3(Gal-3), HbA1c, fasting blood glucose (FBG) and fasting insulin (FINS) 
      in maternal peripheral blood and neonatal cord blood were detected by ELISA. 
      Spearman's rank correlation test was used to assess the association between 
      peripheral Slit-2 and inflammatory indicators, insulin resistance, and pregnancy 
      outcomes. Logistic regression analysis was used to analyze the risk factors of 
      GDM. RESULTS: Slit-2 levels in maternal peripheral blood and neonatal cord blood 
      of the GDM patients were higher than those of the HC. Slit-2 levels in maternal 
      peripheral blood and neonatal cord blood of the GDM patients were positively 
      correlated with inflammatory factors CRP and MCP-1 levels. The level of Slit-2 in 
      the maternal peripheral blood of the GDM patients was positively correlated with 
      the level of homeostasis model assessment insulin resistance (HOMA-IR) and HbA1c 
      in maternal peripheral blood, but was negatively correlated with the level of 
      homeostasis model assessment -beta (HOMA-beta). We also found that the Slit-2 level in 
      the maternal peripheral blood of the GDM patients was negatively correlated with 
      neonatal blood glucose, positively correlated with neonatal weight and 
      independent of neonatal total bilirubin. CONCLUSION: Our study suggests that the 
      abnormal increase in Slit-2 in GDM may be related to its pathogenesis, and it was 
      correlated with neonatal blood glucose and weight in patients with GDM, 
      suggesting that Slit-2 may be a potential biomarker of GDM.
CI  - Copyright (c) 2022 Wang, Zhao, Peng, Chen, Chi, Che and Wang.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Zhao, Shihua
AU  - Zhao S
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Peng, Wei
AU  - Peng W
AD  - Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Chen, Ying
AU  - Chen Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Chi, Jingwei
AU  - Chi J
AD  - Qingdao Key Laboratory of Thyroid Diseases, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Che, Kui
AU  - Che K
AD  - Qingdao Key Laboratory of Thyroid Diseases, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Wang, Yangang
AU  - Wang Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220623
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - R6FXH13RRC (Slit homolog 2 protein)
SB  - IM
MH  - Blood Glucose/analysis
MH  - C-Reactive Protein/analysis
MH  - *Diabetes, Gestational/metabolism
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Infant, Newborn
MH  - *Insulin Resistance
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Nerve Tissue Proteins/*metabolism
MH  - Pregnancy
MH  - Pregnancy Outcome
PMC - PMC9261261
OTO - NOTNLM
OT  - Slit guidance ligand 2
OT  - cord blood
OT  - gestational diabetes mellitus (GDM)
OT  - peripheral blood
OT  - pregnancy outcome
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/12 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/01/01
CRDT- 2022/07/11 04:05
PHST- 2022/03/04 00:00 [received]
PHST- 2022/05/19 00:00 [accepted]
PHST- 2022/07/11 04:05 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.889505 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jun 23;13:889505. doi: 
      10.3389/fendo.2022.889505. eCollection 2022.