PMID- 35814458 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 12 DP - 2022 TI - Case Report: Giant Cell Tumor of Tendon Sheath After Breast Augmentation. PG - 878635 LID - 10.3389/fonc.2022.878635 [doi] LID - 878635 AB - Giant cell tumor of tendon sheath (GCTTS) is a benign tumor. It occurs predominantly in the hands, ankles, and knees. A 39-year-old female presented with GCTTS in the right breast after breast augmentation. There was a clear borderline between the tumor and breast tissue. In terms of morphological appearance, synovial metaplasia could be observed in part of the collagenous capsule. The tumor was moderately cellular and was composed of synovium-like monocytes. The main part of the tumor was blended with nested and scattered xanthomatous cells, lymphocytes, and osteoclast-like giant cells. Hemosiderin granules were distributed in the lesion. Immunohistochemical staining and fluorescence in situ hybridization (FISH) analyses were performed. CD68 staining was positive in osteoclast-like giant cells. In addition, neither significant USP6 translocation nor CSF1 translocation was detected by FISH. We hypothesized that the pathogenesis of this rare GCT-TS was based on synovial metaplasia and did not depend on the translocation of classical CSF1. CI - Copyright (c) 2022 Zhang, Fan, Zhang, Bu, Chen, Yang and Zhang. FAU - Zhang, Yu AU - Zhang Y AD - Department of Pathology, West China Hospital, Sichuan University, Chengdu, China. FAU - Fan, Yingying AU - Fan Y AD - Department of Pathology, West China Second University Hospital, Sichuan University/West China Women's and Children's Hospital, Chengdu, China. FAU - Zhang, Hongying AU - Zhang H AD - Department of Pathology, West China Hospital, Sichuan University, Chengdu, China. FAU - Bu, Hong AU - Bu H AD - Department of Pathology, West China Hospital, Sichuan University, Chengdu, China. AD - Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, China. FAU - Chen, Min AU - Chen M AD - Department of Pathology, West China Hospital, Sichuan University, Chengdu, China. FAU - Yang, Jieliang AU - Yang J AD - Department of Pathology, West China Hospital, Sichuan University, Chengdu, China. FAU - Zhang, Zhang AU - Zhang Z AD - Department of Pathology, West China Hospital, Sichuan University, Chengdu, China. LA - eng PT - Case Reports DEP - 20220622 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC9256978 OTO - NOTNLM OT - CSF1 OT - breast OT - breast augmentation OT - giant cell tumor of tendon sheath OT - synovial metaplasia COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/07/12 06:00 MHDA- 2022/07/12 06:01 PMCR- 2022/01/01 CRDT- 2022/07/11 04:17 PHST- 2022/02/18 00:00 [received] PHST- 2022/05/20 00:00 [accepted] PHST- 2022/07/11 04:17 [entrez] PHST- 2022/07/12 06:00 [pubmed] PHST- 2022/07/12 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fonc.2022.878635 [doi] PST - epublish SO - Front Oncol. 2022 Jun 22;12:878635. doi: 10.3389/fonc.2022.878635. eCollection 2022.