PMID- 35815930
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20220830
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Print)
IS  - 0963-6897 (Linking)
VI  - 31
DP  - 2022 Jan-Dec
TI  - Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due 
      to Anti-N-Methyl-d-Aspartate Receptor Encephalitis: First Case Report.
PG  - 9636897221110876
LID - 10.1177/09636897221110876 [doi]
LID - 09636897221110876
AB  - Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is caused by altered 
      patient immune reactions. This study reports the first patient with severe 
      neurologic sequelae after NMDA receptor encephalitis treated with allogeneic 
      umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs). A 5-year-old 
      girl was diagnosed with NMDA receptor encephalitis and treated with 
      immunosuppressive medicaments and intravenous immunoglobulin (IVIG). Despite 
      intensive therapy, the patient's condition worsened so that allogenic UC-MSC 
      therapy was contemplated. The patient received three intrathecal infusions of 
      xeno- and serum-free cultured UC-MSCs at a dose of 10(6) cells/kg. At baseline 
      and after each UC-MSC administration, the patient was examined by the German Coma 
      Recovery Scale (CRS), the Gross Motor Function Classification System (GMFCS), the 
      Gross Motor Function Measure-88 (GMFM-88), the Manual Ability Classification 
      System (MACS), the Modified Ashworth Scale, and the Denver II test. Before cell 
      therapy, she was in a permanent vegetative state with diffuse cerebral atrophy. 
      Her cognition and motor functions improved progressively after three UC-MSC 
      infusions. At the last visit, she was capable of walking, writing, and counting 
      numbers. Control of urinary and bowel functions was completely recovered. 
      Cerebral atrophy was reduced on brain magnetic resonance imaging (MRI). Overall, 
      the outcomes of this patient suggest a potential cell therapy for autoimmune 
      encephalitis and its neurological consequences.
FAU - Nguyen Thanh, Liem
AU  - Nguyen Thanh L
AUID- ORCID: 0000-0001-5444-1782
AD  - Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Health Care 
      System, Hanoi, Vietnam.
AD  - College of Health Science, VinUniversity, Hanoi, Vietnam.
FAU - Hoang, Van T
AU  - Hoang VT
AD  - Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Health Care 
      System, Hanoi, Vietnam.
FAU - Le Thu, Huong
AU  - Le Thu H
AD  - Vinmec International Hospital, Hanoi, Vietnam.
FAU - Nguyen, Phuong Anh Thi
AU  - Nguyen PAT
AD  - Vinmec International Hospital, Hanoi, Vietnam.
FAU - Hoang, Duc M
AU  - Hoang DM
AD  - Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Health Care 
      System, Hanoi, Vietnam.
FAU - Ngo, Doan Van
AU  - Ngo DV
AD  - Vinmec International Hospital, Hanoi, Vietnam.
FAU - Cao Vu, Hung
AU  - Cao Vu H
AD  - Vietnam National Children's Hospital, Hanoi, Vietnam.
FAU - Nguyen Thi Bich, Van
AU  - Nguyen Thi Bich V
AD  - Vietnam National Children's Hospital, Hanoi, Vietnam.
FAU - Heke, Michael
AU  - Heke M
AD  - Department of Biology, Stanford University, Stanford, CA, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications/diagnosis/therapy
MH  - Atrophy/complications
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - *Mesenchymal Stem Cells
MH  - Receptors, N-Methyl-D-Aspartate/therapeutic use
MH  - Umbilical Cord
PMC - PMC9277426
OTO - NOTNLM
OT  - anti-NMDA receptor encephalitis
OT  - autoimmune encephalitis
OT  - mesenchymal stem cells
OT  - mesenchymal stromal cells
OT  - neurological sequelae
COIS- Declaration of Conflicting Interests: The author(s) declared the following 
      potential conflicts of interest with respect to the research, authorship, and/or 
      publication of this article: L.N.T., V.T.H., H.L.T., P.A.T.N., D.M.H., and D.V.N. 
      are employed by the not-for-profit Vinmec Healthcare System. M.H. declared an 
      advisory role for Regenerative Medicine at Vinmec Healthcare System.
EDAT- 2022/07/12 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/07/11
CRDT- 2022/07/11 08:43
PHST- 2022/07/11 08:43 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/07/11 00:00 [pmc-release]
AID - 10.1177_09636897221110876 [pii]
AID - 10.1177/09636897221110876 [doi]
PST - ppublish
SO  - Cell Transplant. 2022 Jan-Dec;31:9636897221110876. doi: 
      10.1177/09636897221110876.