PMID- 35816172
OWN - NLM
STAT- MEDLINE
DCOM- 20221111
LR  - 20221208
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Linking)
VI  - 16
IP  - 7
DP  - 2022 Jul 26
TI  - Growth of ZIF-8 Nanoparticles In Situ on Graphene Oxide Nanosheets: A 
      Multifunctional Nanoplatform for Combined Ion-Interference and Photothermal 
      Therapy.
PG  - 11428-11443
LID - 10.1021/acsnano.2c05532 [doi]
AB  - The regulation of intracellular ions' overload to interrupt normal bioprocesses 
      and cause cell death has been developed as an efficient strategy (named as 
      ion-interference therapy/IIT) to treat cancer. In this study, we design a 
      multifunctional nanoplatform (called BSArGO@ZIF-8 NSs) by in situ growth of metal 
      organic framework nanoparticles (ZIF-8 NPs) onto the graphene oxide (GO) surface, 
      subsequently reduced by ascorbic acid and modified by bovine serum albumin. This 
      nanocomplex causes the intracellular overload of Zn(2+), an increase of reactive 
      oxygen species (ROS), and exerts a broad-spectrum lethality to different kinds of 
      cancer cells. BSArGO@ZIF-8 NSs can promote cell apoptosis by initiating bim (a 
      pro-apoptotic protein)-mediated mitochondrial apoptotic events, up-regulating 
      PUMA/NOXA expression, and down-regulating the level of Bid/p53AIP1. Meanwhile, 
      Zn(2+) excess triggers cellular dysfunction and mitochondria damage by activating 
      the autophagy signaling pathways and disturbing the intracellular environmental 
      homeostasis. Combined with the photothermal effect of reduced GO (rGO), 
      BSArGO@ZIF-8 NSs mediated ion-interference and photothermal combined therapy 
      leads to effective apoptosis and inhibits cell proliferation and angiogenesis, 
      bringing a higher efficacy in tumor suppression in vivo. This designed Zn-based 
      multifunctional nanoplatform will allow promoting further the development of IIT 
      and the corresponding combined cancer therapy strategy.
FAU - Lv, Chunxu
AU  - Lv C
AD  - Department of Periodontology & Tissue Engineering and Regeneration, School and 
      Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & 
      Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering 
      Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 
      250012, China.
FAU - Kang, Wenyan
AU  - Kang W
AD  - Department of Periodontology & Tissue Engineering and Regeneration, School and 
      Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & 
      Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering 
      Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 
      250012, China.
FAU - Liu, Shuo
AU  - Liu S
AD  - Department of Periodontology & Tissue Engineering and Regeneration, School and 
      Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & 
      Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering 
      Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 
      250012, China.
FAU - Yang, Pishan
AU  - Yang P
AUID- ORCID: 0000-0002-7326-9452
AD  - Department of Periodontology & Tissue Engineering and Regeneration, School and 
      Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & 
      Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering 
      Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 
      250012, China.
FAU - Nishina, Yuta
AU  - Nishina Y
AUID- ORCID: 0000-0002-4958-1753
AD  - Graduate School of Natural Science and Technology, Okayama University, 
      Tsushimanaka, Kita-ku, Okayama, 700-8530, Japan.
AD  - Research Core for Interdisciplinary Sciences, Okayama University, Tsushimanaka, 
      Kita-ku, Okayama, 700-8530, Japan.
FAU - Ge, Shaohua
AU  - Ge S
AUID- ORCID: 0000-0003-3821-5480
AD  - Department of Periodontology & Tissue Engineering and Regeneration, School and 
      Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & 
      Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering 
      Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 
      250012, China.
FAU - Bianco, Alberto
AU  - Bianco A
AUID- ORCID: 0000-0002-1090-296X
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University 
      of Strasbourg, ISIS, Strasbourg, 67000, France.
FAU - Ma, Baojin
AU  - Ma B
AD  - Department of Periodontology & Tissue Engineering and Regeneration, School and 
      Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & 
      Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering 
      Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 
      250012, China.
AD  - CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University 
      of Strasbourg, ISIS, Strasbourg, 67000, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220711
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (graphene oxide)
RN  - 0 (Ions)
SB  - IM
MH  - Humans
MH  - Phototherapy
MH  - Photothermal Therapy
MH  - *Nanoparticles
MH  - *Neoplasms/drug therapy
MH  - Ions
MH  - Cell Line, Tumor
OTO - NOTNLM
OT  - carbon nanomaterials
OT  - metal organic framework
OT  - mitochondria
OT  - phototherapy
OT  - zinc ions
EDAT- 2022/07/12 06:00
MHDA- 2022/11/15 06:00
CRDT- 2022/07/11 10:53
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/07/11 10:53 [entrez]
AID - 10.1021/acsnano.2c05532 [doi]
PST - ppublish
SO  - ACS Nano. 2022 Jul 26;16(7):11428-11443. doi: 10.1021/acsnano.2c05532. Epub 2022 
      Jul 11.