PMID- 35816909
OWN - NLM
STAT- MEDLINE
DCOM- 20220902
LR  - 20220906
IS  - 2468-2942 (Electronic)
IS  - 2468-2942 (Linking)
VI  - 32
DP  - 2022
TI  - Polymer-based drug delivery systems for anticancer drugs: A systematic review.
PG  - 100605
LID - S2468-2942(22)00095-8 [pii]
LID - 10.1016/j.ctarc.2022.100605 [doi]
AB  - Recent advances in nanotechnology sciences lead to the development of new 
      treatment approaches for various diseases such as cancer. Nanotechnology advances 
      can potentially minimize the side effects of drugs through the employment of 
      effective and controlled drug delivery systems (DDSs). Polymers are optimal tools 
      providing drug delivery mechanisms through the unique features of 
      pharmacokinetics, circulation time, biocompatibility, and biodegradability. This 
      systematic review aimed to evaluate polymer-based DDSs for anticancer drugs and 
      their various therapeutic applications in cancer treatment. This study was 
      conducted with no time limitation by November 2021. Related articles were 
      collected through a deep search in English and Persian databases of SID, MagIran, 
      Scopus, Web Of Science (WoS), PubMed, Science Direct, and Google Scholar. 
      Keywords included drug delivery system, anticancer agent, polymeric 
      nanostructure-based drug delivery, polymer-based drug delivery, and polymeric 
      system. As the results showed, polymeric nanoparticles (PNPs) have influential 
      roles in cancer treatment than conventional chemotherapy procedures. PNPs can 
      reduce cytotoxicity following chemotherapy drug administration, improve the 
      solubility characteristics of these therapeutic agents and inhibit the rate of 
      tumor growth.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Salari, Nader
AU  - Salari N
AD  - Department of Biostatistics, School of Health, Kermanshah University of Medical 
      Sciences, Kermanshah, Iran.
FAU - Faraji, Farahnaz
AU  - Faraji F
AD  - Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Torghabeh, Fatemeh Mansouri
AU  - Torghabeh FM
AD  - Department of Physiology Sciences, Medical School, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Faraji, Fatemeh
AU  - Faraji F
AD  - Student research committee, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Mansouri, Kamran
AU  - Mansouri K
AD  - Medical Biology Research Centre, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Abam, Farzaneh
AU  - Abam F
AD  - Medical Biology Research Centre, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Shohaimi, Shamarina
AU  - Shohaimi S
AD  - Department of Biology, Faculty of Science, University Putra Malaysia, Serdang, 
      Selangor, Malaysia.
FAU - Akbari, Hakimeh
AU  - Akbari H
AD  - Cellular and Molecular Research Center, Gerash University of Medical Sciences, 
      Gerash, Iran.
FAU - Mohammadi, Masoud
AU  - Mohammadi M
AD  - Cellular and Molecular Research Center, Gerash University of Medical Sciences, 
      Gerash, Iran. Electronic address: masoud.mohammadi1989@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20220706
PL  - England
TA  - Cancer Treat Res Commun
JT  - Cancer treatment and research communications
JID - 101694651
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Polymers)
SB  - IM
MH  - *Antineoplastic Agents/pharmacology/therapeutic use
MH  - Drug Delivery Systems
MH  - Humans
MH  - *Nanoparticles
MH  - *Neoplasms/drug therapy
MH  - Polymers/therapeutic use
OTO - NOTNLM
OT  - Anticancer agent
OT  - Polymer-based drug delivery
OT  - Systematic review
EDAT- 2022/07/12 06:00
MHDA- 2022/09/03 06:00
CRDT- 2022/07/11 18:23
PHST- 2022/05/10 00:00 [received]
PHST- 2022/06/21 00:00 [revised]
PHST- 2022/07/02 00:00 [accepted]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/09/03 06:00 [medline]
PHST- 2022/07/11 18:23 [entrez]
AID - S2468-2942(22)00095-8 [pii]
AID - 10.1016/j.ctarc.2022.100605 [doi]
PST - ppublish
SO  - Cancer Treat Res Commun. 2022;32:100605. doi: 10.1016/j.ctarc.2022.100605. Epub 
      2022 Jul 6.