PMID- 35817537
OWN - NLM
STAT- MEDLINE
DCOM- 20220713
LR  - 20220713
IS  - 1532-3129 (Electronic)
IS  - 0021-9975 (Linking)
VI  - 195
DP  - 2022 Jul
TI  - Pathogenicity of Porcine Circovirus Type 2e in Experimentally Infected Pigs.
PG  - 19-27
LID - S0021-9975(22)00065-2 [pii]
LID - 10.1016/j.jcpa.2022.05.001 [doi]
AB  - A new porcine circovirus type 2e (PCV2e) genotype was recently isolated from 
      diseased pigs. To investigate the pathogenicity of PCV2e, groups of conventional 
      pigs were inoculated in one of three ways: with PCV2e only, with Mycoplasma 
      hyopneumoniae and PCV2e, or with PCV2e and porcine reproductive and respiratory 
      syndrome virus (PRRSV). Pigs were examined post mortem at 21 days post 
      inoculation. Pigs in the M. hyopeumoniae/PCV2e group were inoculated 
      intratracheally with M. hyopneumoniae at 4 weeks of age followed by an intranasal 
      inoculation with PCV2e at 6 weeks of age. Pigs in the PCV2e/PRRSV group were 
      inoculated intranasally with PCV2e and PRRSV at 6 weeks of age. Significant 
      differences in PCV2e loads in blood or lymph nodes, or in the severity of 
      lymphoid lesions, were not detected between the M. hyopneumoniae/PCV2e and 
      PCV2e/PRRSV groups. All pigs co-infected with either M. hyopneumoniae/PCV2e or 
      PCV2e/PRRSV developed mild porcine circovirus-associated disease (PCVAD), whereas 
      none of the pigs infected with PCV2e alone developed PCVAD. Production of PCVAD 
      in pigs therefore appears to require PCV2e infection simultaneously with an 
      additional infectious agent such as M. hyopneumoniae or PRRSV for full disease 
      expression in pigs. These results demonstrate that PCV2e is not associated with 
      significant clinical disease as assessed by levels of PCV2e viraemia and severity 
      of lymphoid lesions.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Suh, Jeongmin
AU  - Suh J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea. Electronic address: 
      swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20220609
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
SB  - IM
MH  - Animals
MH  - *Circoviridae Infections/veterinary
MH  - *Circovirus
MH  - *Mycoplasma hyopneumoniae
MH  - *Porcine Reproductive and Respiratory Syndrome
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Swine
MH  - *Swine Diseases/pathology
MH  - Virulence
OTO - NOTNLM
OT  - Mycoplasma hyopneumoniae
OT  - pathogenicity
OT  - porcine circovirus type 2e
OT  - porcine circovirus-associated disease
OT  - porcine reproductive and respiratory syndrome virus
EDAT- 2022/07/12 06:00
MHDA- 2022/07/14 06:00
CRDT- 2022/07/11 21:04
PHST- 2022/01/18 00:00 [received]
PHST- 2022/03/24 00:00 [revised]
PHST- 2022/05/11 00:00 [accepted]
PHST- 2022/07/11 21:04 [entrez]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
AID - S0021-9975(22)00065-2 [pii]
AID - 10.1016/j.jcpa.2022.05.001 [doi]
PST - ppublish
SO  - J Comp Pathol. 2022 Jul;195:19-27. doi: 10.1016/j.jcpa.2022.05.001. Epub 2022 Jun 
      9.