PMID- 35817711
OWN - NLM
STAT- MEDLINE
DCOM- 20220823
LR  - 20220904
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 75
IP  - 8
DP  - 2022 Aug
TI  - Radiation therapy modalities for keloid management: A critical review.
PG  - 2455-2465
LID - S1748-6815(22)00280-7 [pii]
LID - 10.1016/j.bjps.2022.04.099 [doi]
AB  - OBJECTIVE: To provide a critical overview of current radiation modalities for 
      keloid management. BACKGROUND: Despite multimodal therapies, keloids that can 
      develop following injury are poorly controlled. A number of studies have 
      suggested that post-excisional radiation therapy can reduce rates of keloid 
      recurrence. However, existing reports span multiple radiation modalities, 
      including brachytherapy, electron beam radiation, and photon radiation. In this 
      review, we describe the advantages and disadvantages of commonly used radiation 
      techniques and highlight their efficacy in keloid management. RESULTS: Electron 
      beam radiation and high-dose rate brachytherapy are the two most commonly used 
      modalities for adjuvant radiotherapeutic management of keloids and can provide 
      effective keloid control but may be suited for different kinds of keloid growth 
      patterns. Increasing biologically equivalent dose (BED) likely improves rates of 
      control, though the clinical significance of this finding remains to be 
      elucidated. Though radiation treatments are associated with acute and chronic 
      side effects, the risk of developing a secondary malignancy is minimal. 
      CONCLUSIONS: While radiation therapy is a promising modality for treating 
      keloids, more studies of a prospective, randomized nature are needed to 
      standardize its utility.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Liu, Elisa K
AU  - Liu EK
AD  - Department of Radiation Oncology, NYU Grossman School of Medicine, New York, NY 
      USA.
FAU - Cohen, Richard F
AU  - Cohen RF
AD  - Department of Radiation Oncology, NYU Grossman School of Medicine, New York, NY 
      USA.
FAU - Chiu, Ernest S
AU  - Chiu ES
AD  - Hansjӧrg Wyss Department of Plastic Surgery, NYU Grossman School of Medicine, New 
      York, NY USA. Electronic address: Ernest.Chiu@nyulangone.org.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220506
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
SB  - IM
MH  - Combined Modality Therapy
MH  - Humans
MH  - *Keloid/etiology/radiotherapy/surgery
MH  - Prospective Studies
MH  - Radiotherapy, Adjuvant/adverse effects
MH  - Recurrence
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Brachytherapy
OT  - Electron beam
OT  - Keloids
OT  - Radiation
EDAT- 2022/07/12 06:00
MHDA- 2022/08/24 06:00
CRDT- 2022/07/11 22:08
PHST- 2021/03/31 00:00 [received]
PHST- 2022/04/12 00:00 [accepted]
PHST- 2022/07/12 06:00 [pubmed]
PHST- 2022/08/24 06:00 [medline]
PHST- 2022/07/11 22:08 [entrez]
AID - S1748-6815(22)00280-7 [pii]
AID - 10.1016/j.bjps.2022.04.099 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2022 Aug;75(8):2455-2465. doi: 
      10.1016/j.bjps.2022.04.099. Epub 2022 May 6.