PMID- 3581774
OWN - NLM
STAT- MEDLINE
DCOM- 19870626
LR  - 20191022
IS  - 0147-9571 (Print)
IS  - 0147-9571 (Linking)
VI  - 10
IP  - 1
DP  - 1987
TI  - In vivo chemotaxis of rat leucocytes to 
      N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP).
PG  - 33-9
AB  - FMLP was potently chemotactic in vivo to rat leucocytes. Doses of 1 microgram 
      attracted net leucocytes into experimental cotton pellets in 6 h. Maximal 
      chemotactic activity occurred at 0.01 mg. Doses greater or less than 0.01 mg 
      attracted less net leucocytes into experimental pellets. The effect of time on 
      chemotaxis of 0.05 mg FMLP showed that between 3 and 36 h, chemotactic index 
      remained above unity and rose maximally to over 1.5. Maximal chemotactic index 
      occurred at 6 h followed by maximal leucocytic infiltration. FMLP showed early 
      chemoattraction in vivo to rat leucocytes. Leucocytic migration into control 
      pellets rose from 3 h, reached maximum levels at 24 h and remained almost at this 
      level at 36 h. L-methionyl-L-leucyl-L-phenylalanine (MLP), studied as a negative 
      control, showed a chemotactic index and chemotactic differential that rose and 
      fell together between 3 and 36 h. The kinetics of migrating leucocyte populations 
      in response to FMLP showed absolute polymorphonuclear leucocytes at 3 h and over 
      90% mononuclear leucocytes at 36 h.
FAU - Onyia, K A
AU  - Onyia KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Comp Immunol Microbiol Infect Dis
JT  - Comparative immunology, microbiology and infectious diseases
JID - 7808924
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Animals
MH  - *Chemotaxis, Leukocyte
MH  - Dose-Response Relationship, Drug
MH  - Leukocytes/*physiology
MH  - Male
MH  - N-Formylmethionine Leucyl-Phenylalanine/*physiology
MH  - Rats
MH  - Structure-Activity Relationship
MH  - Time Factors
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 0147-9571(87)90038-5 [pii]
AID - 10.1016/0147-9571(87)90038-5 [doi]
PST - ppublish
SO  - Comp Immunol Microbiol Infect Dis. 1987;10(1):33-9. doi: 
      10.1016/0147-9571(87)90038-5.