PMID- 35820762
OWN - NLM
STAT- MEDLINE
DCOM- 20220714
LR  - 20220729
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 12
IP  - 7
DP  - 2022 Jul 12
TI  - Dietary antioxidant consumption and the risk of type 2 diabetes in South Korean 
      adults: a prospective cohort study based on the Health Examinees study.
PG  - e065073
LID - 10.1136/bmjopen-2022-065073 [doi]
LID - e065073
AB  - OBJECTIVES: Antioxidants are common dietary compounds with multiple health 
      benefits. This study aimed to identify the association between dietary 
      antioxidant consumption and the incidence of type 2 diabetes (T2D) mellitus 
      (defined using the Korean Diabetes Association criteria) in South Korean adults. 
      DESIGN: Baseline and follow-up data from the Health Examinees (HEXA) study, a 
      large-scale community-based genomic cohort study conducted in South Korea 
      SETTING: A South Korean community. PARTICIPANTS: A total of 20 594 participants, 
      aged 40-79 years, who participated in the baseline and follow-up surveys of the 
      HEXA study were included. After an average of 5 years of follow-up, there were 
      332 men and 360 women with T2D. RESULTS: Participants with the highest total 
      flavonoid consumption (Q5) had a lower risk of T2D (men: HR 0.63; 95% CI 0.42 to 
      0.93; p value for trend=0.0169; and women: HR 0.54; 95% CI 0.438 to 0.78; p value 
      for trend=0.0001) than those with the lowest consumption (Q1). Dietary total 
      antioxidant capacity was significantly inversely associated with the development 
      of T2D mellitus in women participants alone (HR 0.58; 95% CI 0.40 to 0.83; p 
      value for trend=0.0004). Stratified analyses according to age and body mass index 
      (BMI) showed that dietary total flavonoid consumption and total antioxidant 
      capacity had a negative association with the development of T2D in women aged >52 
      years and women with BMI >25 kg/m(2). CONCLUSIONS: Dietary flavonoid consumption 
      and total antioxidant capacity were associated with a lower risk of T2D in South 
      Korean adults, especially in women aged >52 years and overweight. The findings of 
      this study may provide reference data for the modification of dietary guidelines 
      for South Koreans.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Tan, Li-Juan
AU  - Tan LJ
AUID- ORCID: 0000-0002-8970-0884
AD  - Department of Food and Nutrition, Chung-Ang University, Seoul, South Korea.
FAU - Hwang, Su Bin
AU  - Hwang SB
AD  - Department of Food and Nutrition, Chung-Ang University, Seoul, South Korea.
FAU - Jun, Shinyoung
AU  - Jun S
AD  - Department of Cancer Biomedical Science, National Cancer Center Graduate School 
      of Cancer Science and Policy, Goyang, South Korea.
FAU - Joung, Hyojee
AU  - Joung H
AD  - Department of Public Health, Graduate School of Public Health, Seoul National 
      University, Seoul, South Korea.
FAU - Shin, Sangah
AU  - Shin S
AUID- ORCID: 0000-0003-0094-1014
AD  - Department of Food and Nutrition, Chung-Ang University, Seoul, South Korea 
      ivory8320@cau.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20220712
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
SB  - IM
MH  - Adult
MH  - Antioxidants/*chemistry
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Female
MH  - Flavonoids/*chemistry/metabolism
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
PMC - PMC9277397
OTO - NOTNLM
OT  - diabetes & endocrinology
OT  - epidemiology
OT  - nutrition & dietetics
OT  - public health
OT  - statistics & research methods
COIS- Competing interests: None declared.
EDAT- 2022/07/13 06:00
MHDA- 2022/07/15 06:00
PMCR- 2022/07/12
CRDT- 2022/07/12 21:04
PHST- 2022/07/12 21:04 [entrez]
PHST- 2022/07/13 06:00 [pubmed]
PHST- 2022/07/15 06:00 [medline]
PHST- 2022/07/12 00:00 [pmc-release]
AID - bmjopen-2022-065073 [pii]
AID - 10.1136/bmjopen-2022-065073 [doi]
PST - epublish
SO  - BMJ Open. 2022 Jul 12;12(7):e065073. doi: 10.1136/bmjopen-2022-065073.