PMID- 35821658
OWN - NLM
STAT- MEDLINE
DCOM- 20231222
LR  - 20240102
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 63
IP  - 33
DP  - 2023 Nov
TI  - Exploration of natural flavones' bioactivity and bioavailability in chronic 
      inflammation induced-type-2 diabetes mellitus.
PG  - 11640-11667
LID - 10.1080/10408398.2022.2095349 [doi]
AB  - Diabetes, being the most widespread illness, poses a serious threat to global 
      public health. It seems that inflammation plays a critical role in the 
      pathophysiology of diabetes. This review aims to demonstrate a probable link 
      between type 2 diabetes mellitus (T2DM) and chronic inflammation during its 
      development. Additionally, the current review examined the bioactivity of natural 
      flavones and the possible molecular mechanisms by which they influence diabetes 
      and inflammation. While natural flavones possess remarkable anti-diabetic and 
      anti-inflammatory bioactivities, their therapeutic use is limited by the low oral 
      bioavailability. Several factors contribute to the low bioavailability, including 
      poor water solubility, food interaction, and unsatisfied metabolic behaviors, 
      while the diseases (diabetes, inflammation, etc.) causing even less 
      bioavailability. Throughout the years, different strategies have been developed 
      to boost flavones' bioavailability, including structural alteration, biological 
      transformation, and innovative drug delivery system design. This review addresses 
      current advancements in improving the bioavailability of flavonoids in general, 
      and flavones in particular. Clinical trials were also analyzed to provide insight 
      into the potential application of flavonoids in diabetes and inflammatory 
      therapies.
FAU - Miao, Lingchao
AU  - Miao L
AD  - State Key Laboratory of Quality Control in Chinese Medicine, Institute of Chinese 
      Medical Sciences, University of Macau, Macau SAR, China.
FAU - Liu, Conghui
AU  - Liu C
AD  - Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Cheong, Meang Sam
AU  - Cheong MS
AD  - State Key Laboratory of Quality Control in Chinese Medicine, Institute of Chinese 
      Medical Sciences, University of Macau, Macau SAR, China.
FAU - Zhong, Ruting
AU  - Zhong R
AD  - State Key Laboratory of Quality Control in Chinese Medicine, Institute of Chinese 
      Medical Sciences, University of Macau, Macau SAR, China.
FAU - Tan, Yi
AU  - Tan Y
AD  - State Key Laboratory of Quality Control in Chinese Medicine, Institute of Chinese 
      Medical Sciences, University of Macau, Macau SAR, China.
FAU - Rengasamy, Kannan R R
AU  - Rengasamy KRR
AUID- ORCID: 0000-0001-7205-7389
AD  - Department of Pharmacology, Saveetha Dental College, Saveetha Institute of 
      Medical and Technical Sciences (SIMATS), Chennai, India.
FAU - Leung, Susan Wai Sum
AU  - Leung SWS
AD  - Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Cheang, Wai San
AU  - Cheang WS
AD  - State Key Laboratory of Quality Control in Chinese Medicine, Institute of Chinese 
      Medical Sciences, University of Macau, Macau SAR, China.
FAU - Xiao, Jianbo
AU  - Xiao J
AUID- ORCID: 0000-0003-3311-770X
AD  - Department of Analytical and Food Chemistry, Faculty of Sciences, Universidade de 
      Vigo, Nutrition and Bromatology Group, Ourense, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220712
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
RN  - 0 (Flavones)
RN  - 0 (Flavonoids)
SB  - IM
MH  - Humans
MH  - *Flavones/pharmacology
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Biological Availability
MH  - Flavonoids/chemistry
MH  - Inflammation/drug therapy
OTO - NOTNLM
OT  - bioactivity
OT  - bioavailability
OT  - flavones
OT  - inflammation
OT  - type 2 diabetes mellitus
EDAT- 2022/07/14 06:00
MHDA- 2023/12/22 06:42
CRDT- 2022/07/13 01:53
PHST- 2023/12/22 06:42 [medline]
PHST- 2022/07/14 06:00 [pubmed]
PHST- 2022/07/13 01:53 [entrez]
AID - 10.1080/10408398.2022.2095349 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2023 Nov;63(33):11640-11667. doi: 
      10.1080/10408398.2022.2095349. Epub 2022 Jul 12.