PMID- 35822013
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2673-6217 (Electronic)
IS  - 2673-6217 (Print)
IS  - 2673-6217 (Linking)
VI  - 2
DP  - 2021
TI  - Metformin Enhances B Cell Function and Antibody Responses of Elderly Individuals 
      With Type-2 Diabetes Mellitus.
PG  - 715981
LID - 10.3389/fragi.2021.715981 [doi]
LID - 715981
AB  - Our previous work has shown that young and elderly patients with Type-2 Diabetes 
      Mellitus (T2DM) treated with Metformin have optimal B cell function and serum 
      antibodies specific for the seasonal influenza vaccine. In this paper, we have 
      evaluated B cell function and the metabolic requirements of B cell antibody 
      responses in elderly T2DM patients (E(T2DM)) taking or not Metformin, and 
      compared to those of healthy elderly (E(H)) and healthy young (Y(H)) individuals. 
      Results show that Metformin significantly increases in vivo B cell function, 
      measured by influenza vaccine-specific serum antibodies, in E(T2DM) patients to 
      the levels observed in E(H) and more importantly in Y(H) individuals. Metformin 
      also decreases the frequencies of pro-inflammatory B cell subsets, as well as 
      intrinsic inflammation and metabolic requirements of peripheral B cells from 
      E(T2DM). This hyper-metabolic phenotype of B cells from E(T2DM) is needed to 
      support intrinsic inflammation, measured by the expression of transcripts for 
      markers of the senescence-associated secretory phenotype (SASP), and the 
      secretion of autoimmune antibodies. Importantly, B cell function in E(T2DM) 
      patients taking Metformin is not only increased as compared to that in E(T2DM) 
      patients not taking Metformin, but is comparable to B cell function measured in 
      Y(H) individuals. These results altogether strongly support the anti-aging 
      effects of Metformin on humoral immunity.
CI  - Copyright (c) 2021 Frasca, Diaz, Romero and Blomberg.
FAU - Frasca, Daniela
AU  - Frasca D
AD  - Department of Microbiology and Immunology, University of Miami Miller School of 
      Medicine, Miami, FL, United States.
AD  - Sylvester Comprehensive Cancer Center, University of Miami Miller School of 
      Medicine, Miami, FL, United States.
FAU - Diaz, Alain
AU  - Diaz A
AD  - Department of Microbiology and Immunology, University of Miami Miller School of 
      Medicine, Miami, FL, United States.
FAU - Romero, Maria
AU  - Romero M
AD  - Department of Microbiology and Immunology, University of Miami Miller School of 
      Medicine, Miami, FL, United States.
FAU - Blomberg, Bonnie B
AU  - Blomberg BB
AD  - Department of Microbiology and Immunology, University of Miami Miller School of 
      Medicine, Miami, FL, United States.
AD  - Sylvester Comprehensive Cancer Center, University of Miami Miller School of 
      Medicine, Miami, FL, United States.
LA  - eng
PT  - Journal Article
DEP - 20210723
PL  - Switzerland
TA  - Front Aging
JT  - Frontiers in aging
JID - 9918231199706676
PMC - PMC9261392
OTO - NOTNLM
OT  - B cells
OT  - Type-2 Diabetes Mellitus
OT  - aging
OT  - autoimmunity
OT  - inflammation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/14 06:00
MHDA- 2022/07/14 06:01
PMCR- 2021/07/23
CRDT- 2022/07/13 02:11
PHST- 2021/05/27 00:00 [received]
PHST- 2021/07/12 00:00 [accepted]
PHST- 2022/07/13 02:11 [entrez]
PHST- 2022/07/14 06:00 [pubmed]
PHST- 2022/07/14 06:01 [medline]
PHST- 2021/07/23 00:00 [pmc-release]
AID - 715981 [pii]
AID - 10.3389/fragi.2021.715981 [doi]
PST - epublish
SO  - Front Aging. 2021 Jul 23;2:715981. doi: 10.3389/fragi.2021.715981. eCollection 
      2021.