PMID- 35830034
OWN - NLM
STAT- MEDLINE
DCOM- 20220715
LR  - 20220715
IS  - 1678-4219 (Electronic)
IS  - 0004-2803 (Linking)
VI  - 59
IP  - 2
DP  - 2022 Apr-Jun
TI  - GASTROINTESTINAL MOTILITY IN ELDERLY PATIENTS WITH WELL-CONTROLLED TYPE 2 
      DIABETES MELLITUS.
PG  - 231-237
LID - S0004-28032022000200231 [pii]
LID - 10.1590/S0004-2803.202202000-42 [doi]
AB  - BACKGROUND: Gastrointestinal (GI) motility disorders in type 2 diabetes mellitus 
      (T2DM) are common. However, the endpoints in well-controlled T2DM in elderly 
      patients are barely understood. OBJECTIVE: To evaluate GI transit and gastric 
      myoelectric activity in elderly patients with T2DM who were undergoing treatment 
      with metformin and to compare them with non-diabetic healthy controls. METHODS: A 
      total of thirty participants were enrolled in this study: young non-diabetic 
      (n=10), elderly non-diabetic controls (n=10), and patients with T2DM managed with 
      metformin (n=10). After fasting overnight, the participants ingested a standard 
      meal and magnetic markers for non-invasive monitoring of GI transit and gastric 
      contractility using the alternating current biosusceptometry and 
      electrogastrography techniques. RESULTS: Mean gastric emptying time, mean colon 
      arrival time, and mean intestinal transit time were determined. There were no 
      significant differences between the groups and in the parameters evaluated 
      (P>0.05). The frequency and amplitude of gastric myoelectric activity were not 
      different between groups; however, abnormal rhythmic index and the half-bandwidth 
      were slightly higher for both elderly diabetic and non-diabetic groups compared 
      with the young adults (P<0.01 and P<0.05, respectively). CONCLUSION: Our study 
      showed unaltered gastric emptying and intestinal transit in T2DM patients with 
      good glycemic control, and suggest changes in the gastric electrical activity can 
      be a part of aging.
FAU - Sena, Erika M A B
AU  - Sena EMAB
AUID- ORCID: 0000-0003-0539-8866
AD  - Universidade Federal de Alagoas, Hospital Universitario Professor Alberto 
      Antunes, Maceio, AL, Brasil.
FAU - Silva, Dianna V L
AU  - Silva DVL
AUID- ORCID: 0000-0002-6558-9085
AD  - Universidade Estadual de Ciencias da Saude de Alagoas, Centro de Ciencias 
      Integradoras, Maceio, AL, Brasil.
FAU - Americo, Madileine F
AU  - Americo MF
AUID- ORCID: 0000-0001-8474-3765
AD  - Universidade Federal do Mato Grosso, Instituto de Ciencias Biologicas e da Saude, 
      Barra do Garcas, MT, Brasil.
FAU - Nascimento, Jhony W G
AU  - Nascimento JWG
AUID- ORCID: 0000-0001-7244-8275
AD  - Universidade Federal de Alagoas, Rede Nordeste de Biotecnologia, Maceio, AL, 
      Brasil.
FAU - Miranda, Jose R A
AU  - Miranda JRA
AUID- ORCID: 0000-0002-8306-8056
AD  - Universidade Estadual Paulista, Departamento de Fisica e Biofisica, Botucatu, SP, 
      Brasil.
FAU - Cora, Luciana A
AU  - Cora LA
AUID- ORCID: 0000-0001-8242-3653
AD  - Universidade Estadual de Ciencias da Saude de Alagoas, Centro de Ciencias 
      Integradoras, Maceio, AL, Brasil.
AD  - Universidade Federal de Alagoas, Rede Nordeste de Biotecnologia, Maceio, AL, 
      Brasil.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Arq Gastroenterol
JT  - Arquivos de gastroenterologia
JID - 15310600R
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Gastric Emptying
MH  - *Gastrointestinal Diseases
MH  - Gastrointestinal Motility
MH  - Gastrointestinal Transit
MH  - Humans
MH  - *Metformin
MH  - Young Adult
EDAT- 2022/07/14 06:00
MHDA- 2022/07/16 06:00
CRDT- 2022/07/13 11:25
PHST- 2021/11/26 00:00 [received]
PHST- 2022/01/10 00:00 [accepted]
PHST- 2022/07/13 11:25 [entrez]
PHST- 2022/07/14 06:00 [pubmed]
PHST- 2022/07/16 06:00 [medline]
AID - S0004-28032022000200231 [pii]
AID - 10.1590/S0004-2803.202202000-42 [doi]
PST - ppublish
SO  - Arq Gastroenterol. 2022 Apr-Jun;59(2):231-237. doi: 
      10.1590/S0004-2803.202202000-42.