PMID- 35830136
OWN - NLM
STAT- MEDLINE
DCOM- 20220715
LR  - 20220721
IS  - 1807-3107 (Electronic)
IS  - 1806-8324 (Linking)
VI  - 36
DP  - 2022
TI  - Association of the estrogen receptor gene with oral health-related quality of 
      life in patients with dentofacial deformities.
PG  - e089
LID - S1806-83242022000100277 [pii]
LID - 10.1590/1807-3107bor-2022.vol36.0089 [doi]
AB  - This study aimed to evaluate the associations between oral health-related quality 
      of life (OHRQoL) and patient-associated factors and polymorphisms in the estrogen 
      receptor 1 (ESR1) and 2 (ESR2) genes in patients with dentofacial deformities 
      (DFD). This cross-sectional study included 234 adult individuals. Data such as 
      age, sex, and the type of facial profile (I, II, or III), were collected, and the 
      short-form oral health impact profile 14 (OHIP-14) questionnaire was used to 
      assess their OHRQoL. DNA was collected from oral mucosa cells, and the 
      polymorphisms in ESR1 (rs2234693 and rs9340799) and ESR2 (rs1256049 and 
      rs4986938) were evaluated using real-time polymerase chain reaction. The data 
      were subjected to statistical analysis at a significance level of 5%. Individuals 
      over 28 years of age exhibited worse OHRQoL (p = 0.003) than individuals aged 
      less than or equal to 28 years. Women had worse OHRQoL than men (p < 0.001). 
      Profile II individuals had worse OHRQoL in the social disability domain than 
      profile III individuals (p = 0.030). Genetic analysis showed that rs9340799 was 
      associated with OHRQoL in the functional limitation domain, and GG individuals 
      exhibited worse OHRQoL than individuals carrying the AA/AG genotypes (p < 0.030). 
      In the social handicap domain, individuals with GG genotype in rs9340799 
      exhibited worse OHRQoL than AG individuals (p < 0.043). Collectively, our results 
      reveal that factors including age, sex, and type of facial profile, are 
      associated with OHRQoL in patients with DFD. In addition, individuals with the GG 
      genotype in rs9340799 (ESR1) may experience a negative impact on OHRQoL in the 
      functional limitation and social handicap domains.
FAU - Machado, Nilza Cristina
AU  - Machado NC
AUID- ORCID: 0000-0001-6816-7243
AD  - Universidade Positivo - UP, School of Health Sciences, Dental School, Curitiba, 
      PR, Brazil.
FAU - Gerber, Jennifer Tsi
AU  - Gerber JT
AUID- ORCID: 0000-0003-3881-1434
AD  - Universidade Positivo - UP, School of Health Sciences, Dental School, Curitiba, 
      PR, Brazil.
FAU - Santos, Katheleen Miranda Dos
AU  - Santos KMD
AUID- ORCID: 0000-0002-6527-2379
AD  - Universidade Positivo - UP, School of Health Sciences, Dental School, Curitiba, 
      PR, Brazil.
FAU - Bergamaschi, Isabela Polesi
AU  - Bergamaschi IP
AUID- ORCID: 0000-0002-3363-9121
AD  - Universidade Federal do Parana - UFPR, Dental School, Department of Stomatology, 
      Curitiba, PR, Brazil.
FAU - Meger, Michelle Nascimento
AU  - Meger MN
AUID- ORCID: 0000-0002-1776-2373
AD  - Universidade Positivo - UP, School of Health Sciences, Dental School, Curitiba, 
      PR, Brazil.
FAU - Costa, Delson Joao da
AU  - Costa DJD
AUID- ORCID: 0000-0001-7622-6469
AD  - Universidade Federal do Parana - UFPR, Dental School, Department of Stomatology, 
      Curitiba, PR, Brazil.
FAU - Kuchler, Erika Calvano
AU  - Kuchler EC
AUID- ORCID: 0000-0001-5351-2526
AD  - Universidade de Sao Paulo - USP, Ribeirao Preto Dental School, Department of 
      Pediatric Dentistry, Ribeirao Preto, SP, Brazil.
FAU - Scariot, Rafaela
AU  - Scariot R
AUID- ORCID: 0000-0002-4911-6413
AD  - Universidade Federal do Parana - UFPR, Dental School, Department of Stomatology, 
      Curitiba, PR, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220711
PL  - Brazil
TA  - Braz Oral Res
JT  - Brazilian oral research
JID - 101307187
RN  - 0 (ESR1 protein, human)
RN  - 0 (ESR2 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Dentofacial Deformities/genetics
MH  - *Estrogen Receptor alpha/genetics
MH  - *Estrogen Receptor beta/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Oral Health
MH  - Polymorphism, Single Nucleotide
MH  - Quality of Life
EDAT- 2022/07/14 06:00
MHDA- 2022/07/16 06:00
CRDT- 2022/07/13 11:27
PHST- 2021/03/26 00:00 [received]
PHST- 2021/11/03 00:00 [accepted]
PHST- 2022/07/13 11:27 [entrez]
PHST- 2022/07/14 06:00 [pubmed]
PHST- 2022/07/16 06:00 [medline]
AID - S1806-83242022000100277 [pii]
AID - 10.1590/1807-3107bor-2022.vol36.0089 [doi]
PST - epublish
SO  - Braz Oral Res. 2022 Jul 11;36:e089. doi: 10.1590/1807-3107bor-2022.vol36.0089. 
      eCollection 2022.