PMID- 35830338
OWN - NLM
STAT- MEDLINE
DCOM- 20220715
LR  - 20230214
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 208
IP  - 2
DP  - 2022 Aug
TI  - The Effect of Low-Intensity Shock Wave Therapy on Moderate Erectile Dysfunction: 
      A Double-Blind, Randomized, Sham-Controlled Clinical Trial.
PG  - 388-395
LID - 10.1097/JU.0000000000002684 [doi]
AB  - PURPOSE: We conducted the first double-blind, randomized, sham-controlled trial 
      evaluating the efficacy and safety of low-intensity shock wave therapy (LiST) 
      exclusively in patients with moderate erectile dysfunction. MATERIALS AND 
      METHODS: Seventy patients were randomized to 12 sessions of LiST (35) or sham 
      therapy (35) twice weekly. Patients were evaluated at 1 and 3 months after 
      completion of treatment. The proportion of participants attaining minimal 
      clinically important difference (MCID) in the International Index of Erectile 
      Function-Erectile Function (IIEF-EF) and the effect of LiST on erectile function, 
      as well as on safety, were the study outcomes. RESULTS: At 3 months, MCID was 
      attained by 27 (79%) patients in the LiST group compared to 0 patients in the 
      sham group. The risk difference between the 2 groups was 79% (95% confidence 
      interval [CI]: 66-93, p <0.001) and the baseline-adjusted mean 
      between-group-difference in the IIEF-EF was 4.4 points (95% CI: 3.4-5.4, p 
      <0.001). At 1 month, MCID was attained by 20 (59%) patients in the LiST group 
      compared to 1 (2.9%) patient in the sham group. The risk difference between the 2 
      groups was 56% (95% CI: 38-73, p <0.001) and the baseline-adjusted mean 
      between-group-difference in the IIEF-EF was 3.9 points (95% CI: 2.7-5.2, p 
      <0.001). CONCLUSIONS: Twelve sessions of LiST twice weekly for 6 weeks with a 
      treatment protocol of 5,000 impulses, 0.096 mJ/mm(2) energy flux density and 5 Hz 
      frequency are highly effective in patients with moderate erectile dysfunction. 
      Still, further long-term randomized studies are warranted to corroborate our 
      findings.
FAU - Kalyvianakis, Dimitrios
AU  - Kalyvianakis D
AD  - First Department of Urology, G. Gennimatas Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
AD  - Institute for the Study of Urological Diseases, Thessaloniki, Greece.
FAU - Mykoniatis, Ioannis
AU  - Mykoniatis I
AD  - First Department of Urology, G. Gennimatas Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
AD  - Institute for the Study of Urological Diseases, Thessaloniki, Greece.
FAU - Pyrgidis, Nikolaos
AU  - Pyrgidis N
AUID- ORCID: 0000-0002-7707-8426
AD  - Institute for the Study of Urological Diseases, Thessaloniki, Greece.
FAU - Kapoteli, Paraskeui
AU  - Kapoteli P
AD  - First Department of Urology, G. Gennimatas Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Zilotis, Filimon
AU  - Zilotis F
AD  - First Department of Urology, G. Gennimatas Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Fournaraki, Agrippina
AU  - Fournaraki A
AD  - First Department of Urology, G. Gennimatas Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Hatzichristou, Dimitrios
AU  - Hatzichristou D
AD  - First Department of Urology, G. Gennimatas Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
AD  - Institute for the Study of Urological Diseases, Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220506
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
CIN - Int Braz J Urol. 2023 Jan-Feb;49(1):152-154. PMID: 36512464
MH  - Double-Blind Method
MH  - *Erectile Dysfunction
MH  - *Extracorporeal Shockwave Therapy/methods
MH  - Humans
MH  - Male
MH  - Penile Erection
MH  - Treatment Outcome
OTO - NOTNLM
OT  - erectile dysfunction
OT  - extracorporeal shockwave therapy
OT  - randomized controlled trial
EDAT- 2022/07/14 06:00
MHDA- 2022/07/16 06:00
CRDT- 2022/07/13 12:59
PHST- 2022/07/13 12:59 [entrez]
PHST- 2022/07/14 06:00 [pubmed]
PHST- 2022/07/16 06:00 [medline]
AID - 10.1097/JU.0000000000002684 [doi]
PST - ppublish
SO  - J Urol. 2022 Aug;208(2):388-395. doi: 10.1097/JU.0000000000002684. Epub 2022 May 
      6.