PMID- 35833084
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Altered Functional Network Connectivity of Precuneus and Executive Control 
      Networks in Type 2 Diabetes Mellitus Without Cognitive Impairment.
PG  - 887713
LID - 10.3389/fnins.2022.887713 [doi]
LID - 887713
AB  - In epidemiological studies, type 2 diabetes mellitus (T2DM) has been associated 
      with cognitive impairment and dementia, but studies about functional network 
      connectivity in T2DM without cognitive impairment are limited. This study aimed 
      to explore network connectivity alterations that may help enhance our 
      understanding of damage-associated processes in T2DM. MRI data were analyzed from 
      82 patients with T2DM and 66 normal controls. Clinical, biochemical, and 
      neuropsychological assessments were conducted in parallel with resting-state 
      functional magnetic resonance imaging, and the cognitive status of the patients 
      was assessed using the Montreal Cognitive Assessment-B (MoCA-B) score. 
      Independent component analysis revealed a positive correlation between the 
      salience network and the visual network and a negative connection between the 
      left executive control network and the default mode network in patients with 
      T2DM. The differences in dynamic brain network connectivity were observed in the 
      precuneus, visual, and executive control networks. Internal network connectivity 
      was primarily affected in the thalamus, inferior parietal lobe, and left 
      precuneus. Hemoglobin A1c level, body mass index, MoCA-B score, and grooved 
      pegboard (R) assessments indicated significant differences between the two groups 
      (p < 0.05). Our findings show that key changes in functional connectivity in 
      diabetes occur in the precuneus and executive control networks that evolve before 
      patients develop cognitive deficits. In addition, the current study provides 
      useful information about the role of the thalamus, inferior parietal lobe, and 
      precuneus, which might be potential biomarkers for predicting the clinical 
      progression, assessing the cognitive function, and further understanding the 
      neuropathology of T2DM.
CI  - Copyright (c) 2022 Wu, Kang, Su, Liu, Fan, Ma, Tan, Huang, Feng, Chen, Lyu, Zeng, 
      Qiu and Hu.
FAU - Wu, Jinjian
AU  - Wu J
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Kang, Shangyu
AU  - Kang S
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Su, Jianpo
AU  - Su J
AD  - College of Intelligence Science and Technology, National University of Defense 
      Technology, Changsha, China.
FAU - Liu, Kai
AU  - Liu K
AD  - College of Intelligence Science and Technology, National University of Defense 
      Technology, Changsha, China.
FAU - Fan, Liangwei
AU  - Fan L
AD  - College of Intelligence Science and Technology, National University of Defense 
      Technology, Changsha, China.
FAU - Ma, Xiaomeng
AU  - Ma X
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Tan, Xin
AU  - Tan X
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Huang, Haoming
AU  - Huang H
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Feng, Yue
AU  - Feng Y
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Chen, Yuna
AU  - Chen Y
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Lyu, Wenjiao
AU  - Lyu W
AD  - The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Zeng, Lingli
AU  - Zeng L
AD  - College of Intelligence Science and Technology, National University of Defense 
      Technology, Changsha, China.
FAU - Qiu, Shijun
AU  - Qiu S
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Hu, Dewen
AU  - Hu D
AD  - College of Intelligence Science and Technology, National University of Defense 
      Technology, Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20220627
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9271612
OTO - NOTNLM
OT  - cognitive impairment
OT  - functional magnetic resonance imaging
OT  - network connectivity
OT  - precuneus
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/15 06:00
MHDA- 2022/07/15 06:01
PMCR- 2022/01/01
CRDT- 2022/07/14 02:34
PHST- 2022/03/01 00:00 [received]
PHST- 2022/06/08 00:00 [accepted]
PHST- 2022/07/14 02:34 [entrez]
PHST- 2022/07/15 06:00 [pubmed]
PHST- 2022/07/15 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.887713 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Jun 27;16:887713. doi: 10.3389/fnins.2022.887713. 
      eCollection 2022.