PMID- 3583403
OWN - NLM
STAT- MEDLINE
DCOM- 19870723
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 9
IP  - 6
DP  - 1987 Jun
TI  - Possible association of MN locus haplotypes with essential hypertension.
PG  - 634-40
AB  - Five multigenerational kindreds with familial hypertension were typed for human 
      leukocyte antigen (HLA) and blood group antigens to investigate genetic factors 
      that influence variability in blood pressure. Pedigree analysis revealed that 
      children of matings in which both parents were hypertensive had a significantly 
      greater risk of hypertension than children of matings in which one parent or 
      neither parent was hypertensive. Blood types N and MN were abnormally distributed 
      among hypertensive as compared with normotensive members of white but not black 
      families. The distribution of ABO and Rh types was not significantly different 
      between hypertensive and normotensive siblings. When all possible pairings of 
      siblings were examined for HLA haplotype sharing, abnormal distributions were 
      observed among hypertensive sib pairs whereas the expected mendelian segregation 
      was observed among hypertensive-normotensive sib pairs and 
      normotensive-normotensive sib pairs. These results suggest the genetic factors 
      controlling variation in blood pressure may include loci in the region of the MN 
      locus on chromosome 4 and, possibly, the major histocompatibility complex on 
      chromosome 6.
FAU - Heise, E R
AU  - Heise ER
FAU - Moore, M A
AU  - Moore MA
FAU - Reid, Q B
AU  - Reid QB
FAU - Goodman, H O
AU  - Goodman HO
LA  - eng
GR  - HL 07304/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Blood Group Antigens)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Blood Group Antigens/*genetics
MH  - Female
MH  - HLA Antigens/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Hypertension/*genetics
MH  - Male
MH  - Pedigree
MH  - Phenotype
EDAT- 1987/06/01 00:00
MHDA- 1987/06/01 00:01
CRDT- 1987/06/01 00:00
PHST- 1987/06/01 00:00 [pubmed]
PHST- 1987/06/01 00:01 [medline]
PHST- 1987/06/01 00:00 [entrez]
AID - 10.1161/01.hyp.9.6.634 [doi]
PST - ppublish
SO  - Hypertension. 1987 Jun;9(6):634-40. doi: 10.1161/01.hyp.9.6.634.