PMID- 35834943 OWN - NLM STAT- MEDLINE DCOM- 20231023 LR - 20231023 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 166 DP - 2022 Aug TI - Exposure to perfluoroalkyl substances and neurodevelopment in 2-year-old children: A prospective cohort study. PG - 107384 LID - S0160-4120(22)00311-7 [pii] LID - 10.1016/j.envint.2022.107384 [doi] AB - BACKGROUND: Humans are widely exposed to per- and polyfluoroalkyl substances (PFAS). As fetal stage is a critical window for neurodevelopment, it is important to know if in utero exposure to PFAS affects fetal neurodevelopment. However, previous human studies are both limited and inconsistent. OBJECTIVES: To investigate the relationship between PFAS exposure during early pregnancy and the neurodevelopmental status at 2 years of age in a prospective cohort study. METHODS: We measured 10 PFAS in maternal plasma samples collected prior to 16 weeks of gestation in the Shanghai Birth Cohort Study between 2013 and 2016. Childhood neurodevelopment was assessed at 2 years of age using the Bayley Scales of Infant and Toddler Development-Third Edition (BSID-III). Associations with domain specific scores for individual PFAS were assessed by multiple linear regression and binary logistic regression when scores were dichotomized. Quantile-based g-computation was used to estimate the joint effects of PFAS mixture. RESULTS: A total of 2257 mother-child pairs who had both PFAS and BSID measurements were included in our analyses. The means and standard deviations of comprehensive scores were 115 +/- 22, 96 +/- 15 and 108 +/- 15 for cognition, language, and motor, respectively. In multiple linear regressions, we observed significant negative associations of perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDeA), perfluoroundecanoic acid (PFUnDA) with cognitive scores; PFNA, PFDeA, PFUnDA and perfluorohexanesulfonate (PFHxS) negatively with language scores; and PFNA and PFUnDA negatively with motor scores. Quantile-based g-computation showed that PFAS mixture was significantly associated with decreased cognitive and language scores, with an estimated beta of -2.1 [95% confidence interval (CI): -3.5, -0.7)] and -2.0 (95% CI: -2.9, -1.0) per one quartile increase in PFAS mixture for cognitive and language domains, respectively. PFAS mixture was associated with increased odds of low cognition (adjusted odds ratio [OR] = 1.3, 95% CI:1.0, 1.6) and language scores (OR = 1.2, 95% CI: 1.1, 1.3). CONCLUSIONS: PFAS exposure during early pregnancy was significantly associated with the adverse neurodevelopmental status at 2 years of age, which raises a serious public health concern. CI - Copyright (c) 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Luo, Fei AU - Luo F AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai 200052, China. FAU - Chen, Qian AU - Chen Q AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. FAU - Yu, Guoqi AU - Yu G AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. FAU - Huo, Xiaona AU - Huo X AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China; Obstetrics and Gynecology Department, International Peace Maternity and Child Health Hospital of China, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China. FAU - Wang, Hui AU - Wang H AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. FAU - Nian, Min AU - Nian M AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai 200052, China. FAU - Tian, Ying AU - Tian Y AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai 200052, China. FAU - Xu, Jian AU - Xu J AD - Shanghai Key Laboratory of Embryo Original Diseases, The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Jingsong AU - Zhang J AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China; Department of Medical Psychology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. Electronic address: zhangjinsong@xinhuamed.com.cn. FAU - Zhang, Jun AU - Zhang J AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai 200052, China. Electronic address: junjimzhang@sina.com. CN - Shanghai Birth Cohort LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220707 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (perfluoroundecanoic acid) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 375-95-1 (perfluoro-n-nonanoic acid) RN - 335-76-2 (perfluorodecanoic acid) RN - 0 (Alkanesulfonic Acids) SB - IM MH - Female MH - Pregnancy MH - Infant MH - Humans MH - Child, Preschool MH - Child MH - *Environmental Pollutants/toxicity MH - Cohort Studies MH - Prospective Studies MH - China MH - *Fluorocarbons/toxicity MH - *Alkanesulfonic Acids/toxicity EDAT- 2022/07/15 06:00 MHDA- 2023/10/23 12:44 CRDT- 2022/07/14 18:23 PHST- 2022/03/15 00:00 [received] PHST- 2022/05/28 00:00 [revised] PHST- 2022/06/27 00:00 [accepted] PHST- 2023/10/23 12:44 [medline] PHST- 2022/07/15 06:00 [pubmed] PHST- 2022/07/14 18:23 [entrez] AID - S0160-4120(22)00311-7 [pii] AID - 10.1016/j.envint.2022.107384 [doi] PST - ppublish SO - Environ Int. 2022 Aug;166:107384. doi: 10.1016/j.envint.2022.107384. Epub 2022 Jul 7.