PMID- 35835295
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220927
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 74
DP  - 2022 Oct
TI  - A clinical research of 11cases of human umbilical cord mesenchymal stem cells for 
      curing senile vascular dementia.
PG  - 101669
LID - S0966-3274(22)00143-5 [pii]
LID - 10.1016/j.trim.2022.101669 [doi]
AB  - BACKGROUND: Patients affected by senile vascular dementia (VaD) suffer from a 
      gradual deterioration in their cognitive expressions as well as the ability of 
      taking care for themselves. This study aimed to investigate the clinical efficacy 
      and safety of improving cognitive function and daily life activities of patients 
      with VaD by transplanting human umbilical cord mesenchymal stem cells (HUCMSCs). 
      METHODS: A total number of 11 patients with senile VaD, who were admitted through 
      outpatient treatment and hospitalized between February 2013 and February 2016, 
      were selected. The diagnosis was based on CT and MRI examinations. The cultivated 
      HUCMSCs (10(6) /kg) were injected by intravenous (i.v.) infusion on three 
      occasions. Patients were evaluated for the Mini-Mental State Examination (MMSE) 
      with 25-30 as normal, 21-24 as mild dementia, 10-20 as moderate dementia, and 0-9 
      as severe dementia. In addition, the Barthel index (BI) was used for a 
      standardized activities of daily living (ADLs) with 0-20 as total dependence, 
      21-60 as severe dependence, 61-90 as moderate dependence, and 91-95 slight 
      dependence. The t-test was performed to compare statistical significance. 
      RESULTS: The study included 11 subjects, one of whom fell out due to an event 
      unrelated to the study. The results show descriptive statistics at different time 
      points. No matter MMSE score or Barthel index, the difference between before 
      treatment and after treatment or follow-up was statistically significant (P < 
      0.001).Result interpretation: this intervention method has a significant 
      therapeutic effect, and in the 3-month follow-up period, the intervention effect 
      is still significant compared with that before treatment. CONCLUSIONS: Our 
      preliminary clinical observations suggest that the i.v. infusion of HUCMSCs 
      significantly improved the cognitive function (MMSE) and daily life activities 
      (BI) of patients with senile VaD. This approach may prove to be safe and 
      relatively simple method to be applied for the treatment of senile VaD.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Master, You Li
AU  - Master YL
AD  - Department of Geriatric, The Second People's Hospital of Kunming, Kunming, Yunnan 
      650204, China.
FAU - Wei-Meng Tian, Bachelor
AU  - Wei-Meng Tian B
AD  - Department of Geriatric, The Second People's Hospital of Kunming, Kunming, Yunnan 
      650204, China. Electronic address: wmt2053_drtian@163.com.
FAU - Xing-Fang Jin, Master
AU  - Xing-Fang Jin M
AD  - Department of Geriatric, Yan'an Hospital of Kunming City, Kunming, Yunnan 650051, 
      China.
FAU - Zong-Liu Hou, Postgraduates
AU  - Zong-Liu Hou P
AD  - Department of Geriatric, Yan'an Hospital of Kunming City, Kunming, Yunnan 650051, 
      China.
FAU - Jing-Ping-Wang, Bachelor
AU  - Jing-Ping-Wang B
AD  - Department of Geriatric, The Second People's Hospital of Kunming, Kunming, Yunnan 
      650204, China.
FAU - Yun-Shan Zhang, Bachelor
AU  - Yun-Shan Zhang B
AD  - Department of Geriatric, The Second People's Hospital of Kunming, Kunming, Yunnan 
      650204, China.
FAU - Feng-Yun Luo, Bachelor
AU  - Feng-Yun Luo B
AD  - Department of Geriatric, The Second People's Hospital of Kunming, Kunming, Yunnan 
      650204, China.
FAU - Jian-Pei Su, Master
AU  - Jian-Pei Su M
AD  - Department of Geriatric, The Second People's Hospital of Kunming, Kunming, Yunnan 
      650204, China.
FAU - Jun Wang, Bachelor
AU  - Jun Wang B
AD  - Department of Geriatric, Yan'an Hospital of Kunming City, Kunming, Yunnan 650051, 
      China.
FAU - Ming-Hui Meng, Postgraduates
AU  - Ming-Hui Meng P
AD  - Department of Geriatric, Yan'an Hospital of Kunming City, Kunming, Yunnan 650051, 
      China.
FAU - Yan He, Postgraduates
AU  - Yan He P
AD  - Department of Geriatric, Yan'an Hospital of Kunming City, Kunming, Yunnan 650051, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220711
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
SB  - IM
MH  - Activities of Daily Living
MH  - *Alzheimer Disease/diagnosis/drug therapy
MH  - *Dementia/diagnosis/therapy
MH  - *Dementia, Vascular/diagnosis/drug therapy
MH  - Humans
MH  - *Mesenchymal Stem Cells
MH  - Umbilical Cord
OTO - NOTNLM
OT  - Clinical research
OT  - Human umbilical cord mesenchymal stem cells
OT  - Senile vascular dementia
EDAT- 2022/07/15 06:00
MHDA- 2022/08/17 06:00
CRDT- 2022/07/14 19:35
PHST- 2022/03/10 00:00 [received]
PHST- 2022/07/08 00:00 [revised]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/07/15 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/07/14 19:35 [entrez]
AID - S0966-3274(22)00143-5 [pii]
AID - 10.1016/j.trim.2022.101669 [doi]
PST - ppublish
SO  - Transpl Immunol. 2022 Oct;74:101669. doi: 10.1016/j.trim.2022.101669. Epub 2022 
      Jul 11.