PMID- 35835398
OWN - NLM
STAT- MEDLINE
DCOM- 20220920
LR  - 20221019
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 349
DP  - 2022 Sep
TI  - Targeted delivery via albumin corona nanocomplex to renal tubules to alleviate 
      acute kidney injury.
PG  - 401-412
LID - S0168-3659(22)00423-0 [pii]
LID - 10.1016/j.jconrel.2022.07.013 [doi]
AB  - Renal tubular epithelial cell (RTEC) is a critical target cell for the treatment 
      of acute kidney injury (AKI). Despite various RTEC targeting strategies using 
      ligand modified nanoparticles (NPs) following systemic administration, the 
      nonspecific interaction between NPs and plasma proteins greatly weakens the 
      targeting efficiency as well as the stability of NPs. Herein, celastrol (CLT) was 
      entrapped in D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) forming a 
      CLT-loaded nanocomplex core (CT) with a high loading capacity of ~50%. Bovine 
      serum albumin (BSA) was then adsorbed onto the CT surface to afford a complete 
      albumin corona without obvious denaturation (CTB). CTB showed uniform particle 
      size distribution and sufficient stability in vitro and in vivo. Besides 
      clathrin-mediated and macropinocytosis pathways, CTB was actively internalized 
      through megalin receptor-mediated endocytosis in HK-2 cells. Per biodistribution 
      studies, CTB demonstrates enhanced renal tubule-specific distribution and 
      targetability in mice compared to CT without albumin corona. Furthermore, 
      pharmacodynamic studies in vivo further support that CTB effectively alleviated 
      ischemia-reperfusion induced injuries without obvious systemic side effects in 
      AKI mice models.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Qin, Shuo
AU  - Qin S
AD  - Key Laboratory of Drug Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug and Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China; Department 
      of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical 
      Sciences, Beijing 100730, China.
FAU - Wu, Beibei
AU  - Wu B
AD  - Key Laboratory of Drug Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug and Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Gong, Tao
AU  - Gong T
AD  - Key Laboratory of Drug Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug and Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Zhang, Zhi-Rong
AU  - Zhang ZR
AD  - Key Laboratory of Drug Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug and Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Fu, Yao
AU  - Fu Y
AD  - Key Laboratory of Drug Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug and Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic 
      address: yfu4@scu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220714
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Clathrin)
RN  - 0 (Ligands)
RN  - 0 (Low Density Lipoprotein Receptor-Related Protein-2)
RN  - 0 (Succinates)
RN  - 1406-18-4 (Vitamin E)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - *Acute Kidney Injury/drug therapy/metabolism
MH  - Animals
MH  - Clathrin/metabolism
MH  - Kidney Tubules
MH  - Ligands
MH  - Low Density Lipoprotein Receptor-Related Protein-2/metabolism
MH  - Mice
MH  - *Nanoparticles
MH  - Particle Size
MH  - *Reperfusion Injury/drug therapy/metabolism
MH  - Serum Albumin, Bovine/metabolism
MH  - Succinates
MH  - Tissue Distribution
MH  - Vitamin E/pharmacology
MH  - alpha-Tocopherol/pharmacology
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Albumin corona
OT  - Celastrol
OT  - Renal tubular epithelial cell
EDAT- 2022/07/15 06:00
MHDA- 2022/09/21 06:00
CRDT- 2022/07/14 19:37
PHST- 2022/04/12 00:00 [received]
PHST- 2022/06/30 00:00 [revised]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/07/15 06:00 [pubmed]
PHST- 2022/09/21 06:00 [medline]
PHST- 2022/07/14 19:37 [entrez]
AID - S0168-3659(22)00423-0 [pii]
AID - 10.1016/j.jconrel.2022.07.013 [doi]
PST - ppublish
SO  - J Control Release. 2022 Sep;349:401-412. doi: 10.1016/j.jconrel.2022.07.013. Epub 
      2022 Jul 14.