PMID- 35835890
OWN - NLM
STAT- MEDLINE
DCOM- 20220914
LR  - 20221120
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 129
IP  - 10
DP  - 2022 Oct
TI  - Wearable sensor device-based detection of decreased heart rate variability in 
      Parkinson's disease.
PG  - 1299-1306
LID - 10.1007/s00702-022-02528-y [doi]
AB  - The evidence that heart rate variability (HRV) decreases during early Parkinson's 
      disease (PD) largely depends on electrocardiogram data. In this study, we 
      examined HRV in PD using wearable sensors and assessed various evaluation methods 
      for detecting disease-related alterations. We evaluated 27 patients with PD and 
      23 disease controls. The wearable sensors POLAR V800 HR and POLAR H10 were used 
      for the HRV measurements. The participants wore the two sensors for approximately 
      24 h, and long-term HRV data were acquired. We analyzed the standard deviation of 
      normal R-R intervals (SDNN) and coefficient of variation of R-R intervals (CVRR) 
      for every 100 consecutive beats. Focusing on the fluctuation of SDNN and CVRR, we 
      extracted the minimum, first decile, first quartile, and median values of SDNN 
      and CVRR. The area under the receiver operating characteristic curve (AUC) for 
      each HRV parameter was calculated to differentiate PD from the disease controls. 
      The minimum values of SDNN and CVRR had the highest AUC (SDNN: AUC 0.90, 95% 
      confidence interval [CI] 0.78-0.96; CVRR: AUC 0.90, CI 0.76-0.96) among the 
      evaluation methods tested. The minimum values of SDNN and CVRR were significantly 
      decreased in PD (SDNN: 9.5 +/- 4.0 ms vs. 4.4 +/- 2.0 ms, p < 0.0001; CVRR: 
      1.15 +/- 0.33% vs. 0.65 +/- 0.24%, p < 0.0001). We detected decreased HRV in PD 
      using wearable sensors. Analyzing the minimum values of the HRV parameter in 
      long-term recordings appears to be appropriate for detecting the decrease in HRV 
      in PD.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Suzuki, Masashi
AU  - Suzuki M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho Showa-ku, Nagoya, 466-8550, Japan.
AD  - Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan.
FAU - Nakamura, Tomohiko
AU  - Nakamura T
AD  - Department of Neurology, Hamamatsu University School of Medicine, Hamamatsu, 
      Japan.
FAU - Hirayama, Masaaki
AU  - Hirayama M
AD  - Department of Pathophysiological Laboratory Science, Nagoya University Graduate 
      School of Medicine, Nagoya, Japan.
FAU - Ueda, Masamichi
AU  - Ueda M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho Showa-ku, Nagoya, 466-8550, Japan.
FAU - Hatanaka, Mai
AU  - Hatanaka M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho Showa-ku, Nagoya, 466-8550, Japan.
FAU - Harada, Yumiko
AU  - Harada Y
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho Showa-ku, Nagoya, 466-8550, Japan.
AD  - Public Health Informatics Unit, Department of Neurology, National Hospital 
      Organization Nagoya Medical Center, Nagoya, Japan.
FAU - Nakatochi, Masahiro
AU  - Nakatochi M
AD  - Department of Integrated Health Sciences, Nagoya University Graduate School of 
      Medicine, Nagoya, Japan.
FAU - Nakatsubo, Daisuke
AU  - Nakatsubo D
AD  - Department of Neurosurgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
AD  - Focused Ultrasound Therapy Center, Nagoya Kyoritsu Hospital, Nagoya, Japan.
FAU - Maesawa, Satoshi
AU  - Maesawa S
AD  - Focused Ultrasound Therapy Center, Nagoya Kyoritsu Hospital, Nagoya, Japan.
AD  - Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
FAU - Saito, Ryuta
AU  - Saito R
AD  - Department of Neurosurgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Fujiwara, Koichi
AU  - Fujiwara K
AD  - Department of Material Process Engineering, Nagoya University, Nagoya, Japan.
FAU - Katsuno, Masahisa
AU  - Katsuno M
AUID- ORCID: 0000-0001-9453-9311
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, 65 
      Tsurumai-cho Showa-ku, Nagoya, 466-8550, Japan. ka2no@med.nagoya-u.ac.jp.
AD  - Department of Clinical Research Education, Nagoya University Graduate School of 
      Medicine, Nagoya, Japan. ka2no@med.nagoya-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220714
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
SB  - IM
MH  - Electrocardiography
MH  - Heart Rate/physiology
MH  - Humans
MH  - *Parkinson Disease/diagnosis
MH  - *Wearable Electronic Devices
OTO - NOTNLM
OT  - Autonomic dysfunction
OT  - Autonomic nervous system
OT  - Heart rate variability
OT  - Parkinson's disease
OT  - Wearable sensor device
EDAT- 2022/07/15 06:00
MHDA- 2022/09/15 06:00
CRDT- 2022/07/14 23:24
PHST- 2022/05/06 00:00 [received]
PHST- 2022/07/05 00:00 [accepted]
PHST- 2022/07/15 06:00 [pubmed]
PHST- 2022/09/15 06:00 [medline]
PHST- 2022/07/14 23:24 [entrez]
AID - 10.1007/s00702-022-02528-y [pii]
AID - 10.1007/s00702-022-02528-y [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2022 Oct;129(10):1299-1306. doi: 
      10.1007/s00702-022-02528-y. Epub 2022 Jul 14.