PMID- 35836165
OWN - NLM
STAT- MEDLINE
DCOM- 20220718
LR  - 20220801
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 23
IP  - 1
DP  - 2022 Jul 14
TI  - Creatinine-to-cystatin C ratio as a marker of sarcopenia for identifying 
      osteoporosis in male patients with type 2 diabetes mellitus.
PG  - 672
LID - 10.1186/s12891-022-05636-8 [doi]
LID - 672
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with the increased 
      incidence rate of sarcopenia and osteoporosis. Serum creatinine-to-cystatin C 
      ratio (CCR) is a novel and simple tool which can be used as an index of 
      sarcopenia. This study aims to investigate the association between CCR and 
      osteoporosis as well as bone mineral density (BMD) in T2DM patients. METHODS: 
      Four hundred eighteen T2DM patients were recruited, including 166 females and 252 
      males. General information, BMD data and laboratory data were collected. The 
      correlation between CCR, BMD, bone metabolism markers and osteoporosis was 
      explored by spearman correlation, receiver-operating characteristic (ROC) curve 
      analysis and multiple regression analysis. RESULTS: Spearman correlation analysis 
      showed that there was a positive correlation between CCR and BMD as well as serum 
      calcium in male patients (r = 0.181-0.381, P < 0.01), but such correlation was 
      not found in the female group. In multivariate regression analysis, it was found 
      that there was a significant correlation between CCR and BMD of total lumbar 
      spine, hip as well as femoral neck in male patients. ROC curve showed that the 
      optimal cut-off value of CCR for predicting osteoporosis in male patients was 
      6.73 with the sensitivity of 88% and specificity of 63%. CONCLUSION: In male T2DM 
      patients, CCR was negatively correlated with osteoporosis and positively 
      correlated with BMD.
CI  - (c) 2022. The Author(s).
FAU - Dai, Huifang
AU  - Dai H
AD  - Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang 
      Province, People's Republic of China.
FAU - Xu, Jing
AU  - Xu J
AD  - Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang 
      Province, People's Republic of China. 47914057@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20220714
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - 0 (Biomarkers)
RN  - 0 (Cystatin C)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
EIN - BMC Musculoskelet Disord. 2022 Aug 1;23(1):737. PMID: 35915432
MH  - Absorptiometry, Photon
MH  - Biomarkers
MH  - Bone Density
MH  - Creatinine
MH  - Cystatin C
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - *Osteoporosis/diagnosis/epidemiology
MH  - *Sarcopenia/complications/diagnosis/epidemiology
PMC - PMC9281094
OTO - NOTNLM
OT  - Bone mineral density
OT  - Osteoporosis
OT  - Type2 diabetes
COIS- The authors declare that they have no competing interests.
EDAT- 2022/07/15 06:00
MHDA- 2022/07/19 06:00
PMCR- 2022/07/14
CRDT- 2022/07/14 23:40
PHST- 2022/02/16 00:00 [received]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/07/14 23:40 [entrez]
PHST- 2022/07/15 06:00 [pubmed]
PHST- 2022/07/19 06:00 [medline]
PHST- 2022/07/14 00:00 [pmc-release]
AID - 10.1186/s12891-022-05636-8 [pii]
AID - 5636 [pii]
AID - 10.1186/s12891-022-05636-8 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2022 Jul 14;23(1):672. doi: 10.1186/s12891-022-05636-8.