PMID- 35837763
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20221227
IS  - 2055-5822 (Electronic)
IS  - 2055-5822 (Linking)
VI  - 9
IP  - 5
DP  - 2022 Oct
TI  - Serum microRNAs are key predictors of long-term heart failure and cardiovascular 
      death after myocardial infarction.
PG  - 3367-3379
LID - 10.1002/ehf2.13919 [doi]
AB  - BACKGROUND: Patients with acute myocardial infarction (MI) are at high risk of 
      upcoming events, in particular heart failure (HF), but reliable stratification 
      methods are lacking. Our goal was to evaluate the potential role of circulating 
      miRNAs as prognostic biomarkers in patients presenting with MI. METHODS AND 
      RESULTS: We conducted a prospective study among 311 consecutive patients 
      hospitalized with MI (65% ST-segment elevation MI & median age of 55 years) with 
      long-term follow-up. An initial screening was conducted to select candidate 
      miRNAs, with subsequent study of 14 candidate miRNAs. The primary outcome was the 
      composite of hospital admission for HF or cardiovascular death. During a mean 
      follow-up of 2.1 years miR-21-5p, miR-23a-3p, miR27b-3p, miR-122-5p, miR210-3p, 
      and miR-221-3p reliably predicted the primary outcome. Multivariate Cox 
      regression analyses highlighted that miR-210-3p [hazard ratio (HR) 2.65 per 1 SD 
      increase, P < 0.001], miR-23a-3p (HR 2.11 per 1 SD increase, P < 0.001), and 
      miR-221-3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict 
      the primary outcome, as well as cardiovascular death, HF hospitalizations, and 
      long-term New York Heart Association (NYHA) functional class. These three miRNAs 
      clearly improved the performance of multivariate clinical models: 
      DeltaC-statistic = 0.10 [95% confidence interval (CI), 0.03-0.17], continuous net 
      reclassification index = 34.8% (95%CI, 5.8-57.4%), and integrated discrimination 
      improvement (P < 0.001). CONCLUSIONS: This is the largest study evaluating the 
      prognostic value of circulating miRNAs for HF-related events among patients with 
      MI. We show that several miRNAs predict HF hospitalizations, cardiovascular 
      mortality, and poor long-term NYHA status and improve current risk prediction 
      methods.
CI  - (c) 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on 
      behalf of European Society of Cardiology.
FAU - Rincon, Luis M
AU  - Rincon LM
AUID- ORCID: 0000-0003-1819-5742
AD  - Department of Cardiology, Hospital Universitario Ramon y Cajal, Universidad de 
      Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), 
      Madrid, 28034, Spain.
AD  - Instituto de Investigacion Biomedica de Salamanca (IBSAL), Universidad de 
      Salamanca, Salamanca, Spain.
FAU - Rodriguez-Serrano, Macarena
AU  - Rodriguez-Serrano M
AD  - Biomarkers and Therapeutic Targets Laboratory and Core Facility, Instituto Ramon 
      y Cajal de Investigacion Sanitaria (IRYCIS), Spanish Renal Research Network 
      (REDinREN), Ctra. Colmenar Km 9100, Madrid, 28034, Spain.
FAU - Conde, Elisa
AU  - Conde E
AD  - Biomarkers and Therapeutic Targets Laboratory and Core Facility, Instituto Ramon 
      y Cajal de Investigacion Sanitaria (IRYCIS), Spanish Renal Research Network 
      (REDinREN), Ctra. Colmenar Km 9100, Madrid, 28034, Spain.
FAU - Lanza, Val F
AU  - Lanza VF
AD  - Bioinformatics Core Facility, Instituto Ramon y Cajal de Investigacion Sanitaria 
      (IRYCIS), Madrid, Spain.
FAU - Sanmartin, Marcelo
AU  - Sanmartin M
AD  - Department of Cardiology, Hospital Universitario Ramon y Cajal, Universidad de 
      Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), 
      Madrid, 28034, Spain.
FAU - Gonzalez-Portilla, Paz
AU  - Gonzalez-Portilla P
AD  - Department of Cardiology, Hospital Universitario Ramon y Cajal, Universidad de 
      Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), 
      Madrid, 28034, Spain.
FAU - Paz-Garcia, Marta
AU  - Paz-Garcia M
AD  - Biomarkers and Therapeutic Targets Laboratory and Core Facility, Instituto Ramon 
      y Cajal de Investigacion Sanitaria (IRYCIS), Spanish Renal Research Network 
      (REDinREN), Ctra. Colmenar Km 9100, Madrid, 28034, Spain.
FAU - Del Rey, Jose Manuel
AU  - Del Rey JM
AD  - Department of Biochemistry, Hospital Universitario Ramon y Cajal, Universidad de 
      Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid, 
      Spain.
FAU - Menacho, Miriam
AU  - Menacho M
AD  - Department of Biochemistry, Hospital Universitario Ramon y Cajal, Universidad de 
      Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Madrid, 
      Spain.
FAU - Garcia Bermejo, Maria-Laura
AU  - Garcia Bermejo ML
AD  - Biomarkers and Therapeutic Targets Laboratory and Core Facility, Instituto Ramon 
      y Cajal de Investigacion Sanitaria (IRYCIS), Spanish Renal Research Network 
      (REDinREN), Ctra. Colmenar Km 9100, Madrid, 28034, Spain.
FAU - Zamorano, Jose L
AU  - Zamorano JL
AD  - Department of Cardiology, Hospital Universitario Ramon y Cajal, Universidad de 
      Alcala, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), 
      Madrid, 28034, Spain.
AD  - Hospital La Zarzuela, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220715
PL  - England
TA  - ESC Heart Fail
JT  - ESC heart failure
JID - 101669191
RN  - 0 (MicroRNAs)
RN  - 0 (Biomarkers)
RN  - 0 (Circulating MicroRNA)
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - *MicroRNAs
MH  - Prospective Studies
MH  - Biomarkers
MH  - *Circulating MicroRNA
MH  - *Myocardial Infarction
MH  - *Heart Failure
PMC - PMC9715833
OTO - NOTNLM
OT  - Biomarker
OT  - Heart failure
OT  - MicroRNA
OT  - Myocardial infarction
OT  - Prognosis
COIS- Authors report no conflicts of interest.
EDAT- 2022/07/16 06:00
MHDA- 2022/12/06 06:00
PMCR- 2022/07/15
CRDT- 2022/07/15 03:44
PHST- 2022/02/09 00:00 [revised]
PHST- 2021/08/12 00:00 [received]
PHST- 2022/03/21 00:00 [accepted]
PHST- 2022/07/16 06:00 [pubmed]
PHST- 2022/12/06 06:00 [medline]
PHST- 2022/07/15 03:44 [entrez]
PHST- 2022/07/15 00:00 [pmc-release]
AID - EHF213919 [pii]
AID - 10.1002/ehf2.13919 [doi]
PST - ppublish
SO  - ESC Heart Fail. 2022 Oct;9(5):3367-3379. doi: 10.1002/ehf2.13919. Epub 2022 Jul 
      15.