PMID- 35837791
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221205
IS  - 1529-8019 (Electronic)
IS  - 1396-0296 (Linking)
VI  - 35
IP  - 9
DP  - 2022 Sep
TI  - Cryolipolysis for abdominal subcutaneous fat reduction: A prospective, 
      multicenter, single arm, clinical study.
PG  - e15717
LID - 10.1111/dth.15717 [doi]
AB  - Various treatment methods are used for noninvasive body contouring. To evaluate 
      the efficacy and safety of a newly designed cryolipolysis device using a 
      three-dimensional cooling method for abdominal fat reduction. Twenty-five 
      participants with clinically apparent abdominal fat tissue participated in the 
      study. The thickness of fat tissue below the umbilicus level was measured using a 
      caliper at baseline and 12 weeks after the first treatment. The height of 
      abdominal subcutaneous fat tissue on ultrasonography and participant satisfaction 
      were assessed at every visit for 16 weeks. All adverse events (AEs) during the 
      study period were recorded. p values <0.05 were considered statistically 
      significant. Twenty-four participants completed this study; the mean BMI of 
      participants was 29.34 +/- 2.36 kg/m(2) . The mean thickness of abdominal 
      subcutaneous fat was significantly lower at 12 weeks (40.4 +/- 6.8 mm, p < 0.001) 
      than at baseline (49.3 +/- 8.5 mm). Differences in the height of abdominal 
      subcutaneous fat compared to that at baseline were 1.02 +/- 0.41 cm (12 weeks, 
      p < 0.001) and 1.13 +/- 0.44 cm (16 weeks, p < 0.001). Rates of abdominal 
      subcutaneous fat reduction at 12 and 16 weeks compared to that at baseline were 
      28.45% and 31.13%, respectively. The ratio of abdominal circumference to hip 
      circumference at 12 and 16 weeks was significantly decreased compared to that at 
      baseline. Most participants (95.8%) reported improvement in satisfaction scores 
      at 16 weeks. There were no serious AEs during the entire study period. The study 
      demonstrated the efficacy of a noninvasive cryolipolysis device using a 
      three-dimensional cooling method for reducing abdominal subcutaneous fat.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Choi, Sun Young
AU  - Choi SY
AD  - Department of Dermatology, College of Medicine, Chung-Ang University Hospital, 
      Seoul, South Korea.
FAU - Park, Jae Wan
AU  - Park JW
AUID- ORCID: 0000-0003-2690-6495
AD  - Department of Dermatology, College of Medicine, Chung-Ang University Hospital, 
      Seoul, South Korea.
FAU - Koh, Young Gue
AU  - Koh YG
AD  - Department of Dermatology, College of Medicine, Chung-Ang University Hospital, 
      Seoul, South Korea.
FAU - Jung, You Jin
AU  - Jung YJ
AD  - Department of Dermatology, College of Medicine, Hanyang University, Seoul, South 
      Korea.
FAU - Huh, Yun Jung
AU  - Huh YJ
AD  - Department of Dermatology, College of Medicine, Hanyang University, Seoul, South 
      Korea.
FAU - Ko, Eun Jung
AU  - Ko EJ
AD  - Department of Dermatology, National Police Hospital, Seoul, South Korea.
FAU - Yoo, Kwang Ho
AU  - Yoo KH
AUID- ORCID: 0000-0002-0137-6849
AD  - Department of Dermatology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang 
      University College of Medicine, Gwangmyeong-si, South Korea.
FAU - Seok, Joon
AU  - Seok J
AD  - Department of Dermatology, College of Medicine, Chung-Ang University Hospital, 
      Seoul, South Korea.
FAU - Kim, Soo Yeon
AU  - Kim SY
AD  - CLASSYS Inc., Clinical & Regulatory Affairs Team, Seoul, South Korea.
FAU - Jue, Mihn Sook
AU  - Jue MS
AD  - Department of Dermatology, College of Medicine, Hanyang University, Seoul, South 
      Korea.
FAU - Ko, Joo Yeon
AU  - Ko JY
AUID- ORCID: 0000-0003-4240-9675
AD  - Department of Dermatology, College of Medicine, Hanyang University, Seoul, South 
      Korea.
FAU - Kim, Beom Joon
AU  - Kim BJ
AUID- ORCID: 0000-0003-2320-7621
AD  - Department of Dermatology, College of Medicine, Chung-Ang University Hospital, 
      Seoul, South Korea.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20220728
PL  - United States
TA  - Dermatol Ther
JT  - Dermatologic therapy
JID - 9700070
SB  - IM
MH  - *Body Contouring/adverse effects/methods
MH  - Humans
MH  - *Lipectomy/adverse effects/methods
MH  - Patient Satisfaction
MH  - Prospective Studies
MH  - Subcutaneous Fat, Abdominal/diagnostic imaging/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - 360 degrees  surround cooling technology
OT  - body contouring
OT  - cryolipolysis
OT  - human participants
OT  - noninvasive technique
EDAT- 2022/07/16 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/07/15 03:53
PHST- 2022/07/07 00:00 [revised]
PHST- 2022/05/02 00:00 [received]
PHST- 2022/07/12 00:00 [accepted]
PHST- 2022/07/16 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/07/15 03:53 [entrez]
AID - 10.1111/dth.15717 [doi]
PST - ppublish
SO  - Dermatol Ther. 2022 Sep;35(9):e15717. doi: 10.1111/dth.15717. Epub 2022 Jul 28.