PMID- 35837809
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220816
IS  - 2633-1462 (Electronic)
IS  - 2633-1462 (Linking)
VI  - 3
IP  - 7
DP  - 2022 Jul
TI  - Mapping analysis to predict the associated EuroQol five-dimension three-level 
      utility values from the Oxford Knee Score : a prediction and validation study.
PG  - 573-581
LID - 10.1302/2633-1462.37.BJO-2022-0054.R1 [doi]
AB  - AIMS: The aims of this study were to assess mapping models to predict the 
      three-level version of EuroQoL five-dimension utility index (EQ-5D-3L) from the 
      Oxford Knee Score (OKS) and validate these before and after total knee 
      arthroplasty (TKA). METHODS: A retrospective cohort of 5,857 patients was used to 
      create the prediction models, and a second cohort of 721 patients from a 
      different centre was used to validate the models, all of whom underwent TKA. 
      Patient characteristics, BMI, OKS, and EQ-5D-3L were collected preoperatively and 
      one year postoperatively. Generalized linear regression was used to formulate the 
      prediction models. RESULTS: There were significant correlations between the OKS 
      and EQ-5D-3L preoperatively (r = 0.68; p < 0.001) and postoperatively (r = 0.77; 
      p < 0.001) and for the change in the scores (r = 0.61; p < 0.001). Three 
      different models (preoperative, postoperative, and change) were created. There 
      were no significant differences between the actual and predicted mean EQ-5D-3L 
      utilities at any timepoint or for change in the scores (p > 0.090) in the 
      validation cohort. There was a significant correlation between the actual and 
      predicted EQ-5D-3L utilities preoperatively (r = 0.63; p < 0.001) and 
      postoperatively (r = 0.77; p < 0.001) and for the change in the scores (r = 0.56; 
      p < 0.001). Bland-Altman plots demonstrated that a lower utility was 
      overestimated, and higher utility was underestimated. The individual predicted 
      EQ-5D-3L that was within +/- 0.05 and +/- 0.010 (minimal clinically important 
      difference (MCID)) of the actual EQ-5D-3L varied between 13% to 35% and 26% to 
      64%, respectively, according to timepoint assessed and change in the scores, but 
      was not significantly different between the modelling and validation cohorts (p >/= 
      0.148). CONCLUSION: The OKS can be used to estimate EQ-5D-3L. Predicted 
      individual patient utility error beyond the MCID varied from one-third to 
      two-thirds depending on timepoint assessed, but the mean for a cohort did not 
      differ and could be employed for this purpose. Cite this article: Bone Jt 
      Open 2022;3(7):573-581.
FAU - Clement, Nick D
AU  - Clement ND
AUID- ORCID: 0000-0001-8792-0659
AD  - South West London Elective Orthopaedic Centre, Epsom, UK.
AD  - Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.
FAU - Afzal, Irrum
AU  - Afzal I
AUID- ORCID: 0000-0003-0199-8725
AD  - South West London Elective Orthopaedic Centre, Epsom, UK.
FAU - Peacock, Christian J H
AU  - Peacock CJH
AUID- ORCID: 0000-0002-2733-5295
AD  - South West London Elective Orthopaedic Centre, Epsom, UK.
FAU - MacDonald, Deborah
AU  - MacDonald D
AUID- ORCID: 0000-0003-2682-1408
AD  - Department of Orthopaedics, University of Edinburgh, Edinburgh, UK.
FAU - Macpherson, Gavin J
AU  - Macpherson GJ
AUID- ORCID: 0000-0002-5142-5768
AD  - Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.
AD  - Department of Orthopaedics, University of Edinburgh, Edinburgh, UK.
FAU - Patton, James T
AU  - Patton JT
AUID- ORCID: 0000-0003-2543-1918
AD  - Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.
FAU - Asopa, Vipin
AU  - Asopa V
AUID- ORCID: 0000-0001-8926-1343
AD  - South West London Elective Orthopaedic Centre, Epsom, UK.
FAU - Sochart, David H
AU  - Sochart DH
AD  - South West London Elective Orthopaedic Centre, Epsom, UK.
FAU - Kader, Deiary F
AU  - Kader DF
AUID- ORCID: 0000-0002-8332-2296
AD  - South West London Elective Orthopaedic Centre, Epsom, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bone Jt Open
JT  - Bone & joint open
JID - 101770336
PMC - PMC9350693
OTO - NOTNLM
OT  - Arthroplasty
OT  - BMI
OT  - EQ-5D
OT  - EQ-5D-3L
OT  - Outcome
OT  - Oxford Knee Score
OT  - Pearson correlation
OT  - Predictors
OT  - Spearman correlations
OT  - linear regression analysis
OT  - patient-reported outcome measure (PROM)
OT  - t-test
OT  - total knee arthroplasty (TKA)
EDAT- 2022/07/16 06:00
MHDA- 2022/07/16 06:01
PMCR- 2022/07/01
CRDT- 2022/07/15 03:54
PHST- 2022/07/15 03:54 [entrez]
PHST- 2022/07/16 06:00 [pubmed]
PHST- 2022/07/16 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - BJO-3-573 [pii]
AID - 10.1302/2633-1462.37.BJO-2022-0054.R1 [doi]
PST - ppublish
SO  - Bone Jt Open. 2022 Jul;3(7):573-581. doi: 10.1302/2633-1462.37.BJO-2022-0054.R1.