PMID- 35838801
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220718
IS  - 2730-6011 (Electronic)
IS  - 2730-6011 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Jul 15
TI  - Complete remission of recurrent multiple insulin-producing neuroendocrine tumors 
      of the pancreas with somatostatin analogs: a case report and literature review.
PG  - 66
LID - 10.1007/s12672-022-00531-z [doi]
LID - 66
AB  - Hyperinsulinemic hypoglycemia is most commonly caused by a single, sporadic 
      insulinoma. Multicentric insulinoma disease (insulinomatosis) as well as 
      metachronous neuroendocrine tumors of the pancreas, known also as neuroendocrine 
      adenomatosis, represent a very rare condition, if not associated with multiple 
      endocrine neoplasia type 1 syndrome (MEN1) or Von Hippel Lindau disease. We 
      report a 9-year follow-up of a 41-year-old woman, initially presenting with 
      hypoglycemic syndrome caused by two insulin-producing tumors, who underwent 
      subtotal pancreasectomy in 2012, with histology compatible with multiple small 
      neuroendocrine tumors. An approximately 1-cm insulin-producing tumor recurred at 
      subsequent biochemical and radiological follow-up, and was cured with the 
      somatostatin analog octreotide as a single treatment, until remission of symptoms 
      and complete regression of the pancreatic lesion achieved after only 16 months of 
      treatment. The possible mechanisms for these findings are discussed and the 
      literature is briefly reviewed.
CI  - (c) 2022. The Author(s).
FAU - Tartaglia, Andreas
AU  - Tartaglia A
AD  - Unit of Endocrinology and Metabolism, Morgagni Hospital, Via Carlo Forlanini 34, 
      47100, Forli, Italy. a.tartaglia@ausl.fo.it.
FAU - Busonero, Giulia
AU  - Busonero G
AD  - Unit of Endocrinology and Metabolism, Morgagni Hospital, Via Carlo Forlanini 34, 
      47100, Forli, Italy.
FAU - Gagliardi, Lorenza
AU  - Gagliardi L
AD  - Unit of Endocrinology and Metabolism, Morgagni Hospital, Via Carlo Forlanini 34, 
      47100, Forli, Italy.
FAU - Boddi, Valentina
AU  - Boddi V
AD  - Unit of Endocrinology and Metabolism, Morgagni Hospital, Via Carlo Forlanini 34, 
      47100, Forli, Italy.
FAU - Pieri, Federica
AU  - Pieri F
AD  - Unit of Pathology, Morgagni Hospital, Forli, Italy.
FAU - Nizzoli, Maurizio
AU  - Nizzoli M
AD  - Unit of Endocrinology and Metabolism, Morgagni Hospital, Via Carlo Forlanini 34, 
      47100, Forli, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220715
PL  - United States
TA  - Discov Oncol
JT  - Discover oncology
JID - 101775142
PMC - PMC9287506
OTO - NOTNLM
OT  - Hypoglycemia
OT  - Multicentric insulinomas
OT  - Pancreatic neuroendocrine tumors
OT  - Somatostatin analogs
COIS- The authors declare no potential competing interests.
EDAT- 2022/07/16 06:00
MHDA- 2022/07/16 06:01
PMCR- 2022/07/15
CRDT- 2022/07/15 11:55
PHST- 2022/05/18 00:00 [received]
PHST- 2022/07/06 00:00 [accepted]
PHST- 2022/07/15 11:55 [entrez]
PHST- 2022/07/16 06:00 [pubmed]
PHST- 2022/07/16 06:01 [medline]
PHST- 2022/07/15 00:00 [pmc-release]
AID - 10.1007/s12672-022-00531-z [pii]
AID - 531 [pii]
AID - 10.1007/s12672-022-00531-z [doi]
PST - epublish
SO  - Discov Oncol. 2022 Jul 15;13(1):66. doi: 10.1007/s12672-022-00531-z.