PMID- 35838908
OWN - NLM
STAT- MEDLINE
DCOM- 20220929
LR  - 20220929
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Linking)
VI  - 40
IP  - 5
DP  - 2022 Oct
TI  - Evaluation of Cytotoxic, Necrotic, Apoptotic, and Autophagic Effects of 
      Methamphetamine and 3,4-Methylenedioxymethamphetamine on U-87 MG (Glial) and 
      B104-1-1 (Neuronal) Cell Lines.
PG  - 1499-1515
LID - 10.1007/s12640-022-00543-1 [doi]
AB  - Methamphetamine (MA) and 3,4-methylenedioxymethamphetamine (MDMA) are empathogen 
      (entactogen) psychoactive designer drugs which are mainly used for recreational 
      purposes. Both MA and MDMA are central nervous system stimulants which are 
      classified as monoamine neurotransmitter reuptake inhibitors. They have strong 
      cytotoxic effects on dopaminergic and serotonergic neurons. Neurotoxicities of MA 
      and MDMA by glial activation have been shown. The present work has investigated 
      and measured cytotoxic, necrotic and apoptotic, and autophagic effects of MA and 
      MDMA on U-87 MG (glial) and B104-1-1 (neuronal) cell lines by janus green, 
      ethidium bromide/acridine orange, and monodansylcadaverine/propidium iodide 
      staining to evaluate and compare their effects on glial and neuronal cells, 
      respectively. The results of the present work showed that: (1) MDMA induced more 
      potent mitochondrial toxicity, stronger necrotic and autophagic effects than MA 
      in both B104-1-1 (neuronal) and U-87 MG (glial) cell lines; (2) although MDMA 
      induced stronger apoptotic effect than MA on U-87 MG cell line, it had equal 
      apoptotic effect on B104-1-1 cell line with MA; and (3) MDMA induced more potent 
      mitochondrial toxicity, stronger necrotic, apoptotic, and autophagic effects than 
      MA in B104-1-1 cell line than U-87 MG cell line.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Hosseini, Asieh
AU  - Hosseini A
AD  - Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
FAU - Shetab-Boushehri, Seyed Mohammad-Hossein
AU  - Shetab-Boushehri SM
AD  - Department of Nutrition, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Shetab-Boushehri, Seyed Vahid
AU  - Shetab-Boushehri SV
AD  - Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran. 
      shetab.v@iums.ac.ir.
AD  - Ameretat Shimi Pharmaceutical Co, Tehran, Iran. shetab.v@iums.ac.ir.
LA  - eng
GR  - 14776/Iran University of Medical Sciences/
PT  - Journal Article
DEP - 20220715
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Designer Drugs)
RN  - 36015-30-2 (Propidium)
RN  - 44RAL3456C (Methamphetamine)
RN  - EN464416SI (Ethidium)
RN  - F30N4O6XVV (Acridine Orange)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Acridine Orange/pharmacology
MH  - Cell Line
MH  - *Central Nervous System Stimulants/pharmacology
MH  - *Designer Drugs/pharmacology
MH  - Ethidium
MH  - Humans
MH  - *Methamphetamine/toxicity
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/toxicity
MH  - Necrosis/chemically induced
MH  - Propidium/pharmacology
MH  - Serotonergic Neurons
OTO - NOTNLM
OT  - 3,4-Methylenedioxymethamphetamine
OT  - Apoptosis
OT  - Autophagy
OT  - Cytotoxicity
OT  - Methamphetamine
OT  - Necrosis
EDAT- 2022/07/16 06:00
MHDA- 2022/09/30 06:00
CRDT- 2022/07/15 12:03
PHST- 2022/06/01 00:00 [received]
PHST- 2022/07/01 00:00 [accepted]
PHST- 2022/06/20 00:00 [revised]
PHST- 2022/07/16 06:00 [pubmed]
PHST- 2022/09/30 06:00 [medline]
PHST- 2022/07/15 12:03 [entrez]
AID - 10.1007/s12640-022-00543-1 [pii]
AID - 10.1007/s12640-022-00543-1 [doi]
PST - ppublish
SO  - Neurotox Res. 2022 Oct;40(5):1499-1515. doi: 10.1007/s12640-022-00543-1. Epub 
      2022 Jul 15.