PMID- 35839637
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20220816
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 315
DP  - 2022 Sep
TI  - Parietal-hippocampal rTMS improves cognitive function in Alzheimer's disease and 
      increases dynamic functional connectivity of default mode network.
PG  - 114721
LID - S0165-1781(22)00316-X [pii]
LID - 10.1016/j.psychres.2022.114721 [doi]
AB  - Parietal-hippocampal repetitive transcranial magnetic stimulation (rTMS) improves 
      cognitive function in Alzheimer's disease (AD), however, the underlying 
      therapeutic mechanism has not been elucidated. A double-blind, randomized, 
      sham-controlled parietal-hippocampal rTMS trial (five sessions/week for a total 
      of 10 sessions) of mild-to-moderate AD patients was conducted in the study. 
      High-frequency rTMS was applied to a subject-specific left lateral parietal 
      region with the highest functional connectivity with the hippocampus based on 
      resting-state fMRI. A multimodal MRI scan and a complete neuropsychological 
      battery of tests were conducted at baseline, immediately after the intervention 
      and 12-week follow-up after the rTMS treatment. Compared to sham treatment 
      (n = 27), patients undergoing active rTMS treatment (n = 29) showed higher Mini 
      Mental State Examination (MMSE) score and dynamic functional connectivity (dFC) 
      magnitude of the default mode network (DMN) after two weeks of rTMS treatment, 
      but not at 12-week follow-up. A significant positive correlation was observed 
      between changes in MMSE and changes in the dFC magnitude of DMN in patients who 
      underwent active-rTMS treatment, but not in those who received sham-rTMS 
      treatment. The findings of the current study indicate that fMRI-guided rTMS 
      treatment improves cognitive function of AD patients in the short term, and DMN 
      functional connectivity contributes to therapeutic effectiveness of rTMS.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Wei, Lili
AU  - Wei L
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China.
FAU - Zhang, Yingchun
AU  - Zhang Y
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China.
FAU - Wang, Jintao
AU  - Wang J
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China.
FAU - Xu, Luoyi
AU  - Xu L
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China.
FAU - Yang, Kehua
AU  - Yang K
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China.
FAU - Lv, Xinghui
AU  - Lv X
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China.
FAU - Zhu, Zhenwei
AU  - Zhu Z
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China.
FAU - Gong, Qian
AU  - Gong Q
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China.
FAU - Hu, Weiming
AU  - Hu W
AD  - Third People's Hospital of Quzhou, Quzhou, Zhejiang 324003, China.
FAU - Li, Xia
AU  - Li X
AD  - Shanghai Mental Health Center, Shanghai 200030, China.
FAU - Qian, Mincai
AU  - Qian M
AD  - Third People's Hospital of Huzhou, Huzhou, Zhejiang 313002, China. Electronic 
      address: 1311956613@qq.com.
FAU - Shen, Yuedi
AU  - Shen Y
AD  - Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang 311121, China. 
      Electronic address: shenyd5@126.com.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, East Qingchun Road 3#, Hangzhou, Zhejiang 310016, China; Department 
      of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310007, 
      China; Key Laboratory of Medical Neurobiology of Zhejiang Province, Hangzhou 
      310016, China. Electronic address: srrcw@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20220708
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - *Alzheimer Disease/diagnostic imaging/psychology/therapy
MH  - Cognition/physiology
MH  - Default Mode Network
MH  - Hippocampus/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Transcranial Magnetic Stimulation
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Default mode network
OT  - Dynamic functional connectivity
OT  - Mini Mental State Examination
OT  - Parietal lobe
OT  - Repetitive transcranial magnetic stimulation
EDAT- 2022/07/16 06:00
MHDA- 2022/08/10 06:00
CRDT- 2022/07/15 18:24
PHST- 2022/05/04 00:00 [received]
PHST- 2022/07/06 00:00 [revised]
PHST- 2022/07/07 00:00 [accepted]
PHST- 2022/07/16 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/07/15 18:24 [entrez]
AID - S0165-1781(22)00316-X [pii]
AID - 10.1016/j.psychres.2022.114721 [doi]
PST - ppublish
SO  - Psychiatry Res. 2022 Sep;315:114721. doi: 10.1016/j.psychres.2022.114721. Epub 
      2022 Jul 8.