PMID- 35839957
OWN - NLM
STAT- MEDLINE
DCOM- 20220901
LR  - 20220906
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 217
DP  - 2022 Sep 30
TI  - Poly(L-lactic acid)/poly(ethylene oxide) based composite electrospun fibers 
      loaded with magnesium-aluminum layered double hydroxide nanoparticles.
PG  - 562-571
LID - S0141-8130(22)01485-4 [pii]
LID - 10.1016/j.ijbiomac.2022.07.055 [doi]
AB  - Two types of MgAl layered double hydroxide nanoparticles, MgAl LDH, at Mg:Al 
      ratio of 2:1 and 3:1were prepared and used as inorganic fillers to improve the 
      mechanical properties of poly(lactic acid)/poly(ethylene oxide) (PLA/PEO) 
      electrospun composite fibers. Their detailed structural characterization was 
      performed using X-ray diffraction (XRD) and transmission electron spectroscopy 
      (TEM) techniques. Spectroscopic, thermal, mechanical, and morphological 
      properties of the electrospun composite fibers, and cell proliferation on their 
      surface, were examined. XRD and TEM analyses showed that the LDH nanoparticles 
      were 50 nm in size and the Mg:Al ratio did not affect the average spacing between 
      crystal layers. Fourier transform infrared (FTIR) and thermal analyses (TA) 
      revealed the compatibility of the filler and the polymer matrix. The 
      nanoparticles considerably improved the mechanical properties of the electrospun 
      mats. The tensile strength and elongation at break values of the composite 
      samples increased from 0.22 MPA to 0.40 MPa and 12.2 % to 45.66 %, respectively, 
      resulting from the interaction between LDH and the polymer matrix. Scanning 
      electron microscopy (SEM) and MTT analyses demonstrated that the electrospun 
      composite fibers supported the SaOS-2 cells attachment and proliferation on the 
      fiber surfaces, along with their suitable cytocompatibility.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Ozturk, Esra Altay
AU  - Ozturk EA
AD  - Department of Chemistry, Faculty of Science, Gazi University, Besevler, 06500 
      Ankara, Turkey.
FAU - Ege, Zeynep Ruya
AU  - Ege ZR
AD  - Department of Materials Science and Engineering, Technology Faculty, Marmara 
      University, Aydinevler, Maltepe, 34854, Istanbul, Turkey; Center for 
      Nanotechnology & Biomaterials Application and Research at Marmara University, 
      Aydinevler, Maltepe, 34854 Istanbul, Turkey.
FAU - Murat, Semiha
AU  - Murat S
AD  - Yildiz Technical University, Chemical Engineering Department, Davutpasa, 34210 
      Istanbul, Turkey.
FAU - Erdemir, Gokce
AU  - Erdemir G
AD  - Department of Physiology, Faculty of Medicine, Istanbul University, Istanbul 
      34390, Turkey; Department of Molecular Medicine, Aziz Sancar Institute of 
      Experimental Medicine, Istanbul University, Istanbul 34390, Turkey; Molecular 
      Cancer Research Center (ISUMKAM), Istinye University, Istanbul 34010, Turkey.
FAU - Kuruca, Serap
AU  - Kuruca S
AD  - Department of Physiology, Faculty of Medicine, Istanbul University, Istanbul 
      34390, Turkey.
FAU - Erkmen, Ziya Engin
AU  - Erkmen ZE
AD  - Metallurgical and Materials Engineering Dept., Faculty of Engineering, Marmara 
      University, Aydinevler, Maltepe, 34854, Istanbul, Turkey.
FAU - Duygulu, Ozgur
AU  - Duygulu O
AD  - TUBITAK Marmara Research Center Materials Institute, Gebze, Kocaeli, Turkey.
FAU - Gunduz, Oguzhan
AU  - Gunduz O
AD  - Department of Materials Science and Engineering, Technology Faculty, Marmara 
      University, Aydinevler, Maltepe, 34854, Istanbul, Turkey; Center for 
      Nanotechnology & Biomaterials Application and Research at Marmara University, 
      Aydinevler, Maltepe, 34854 Istanbul, Turkey.
FAU - Caykara, Tuncer
AU  - Caykara T
AD  - Department of Chemistry, Faculty of Science, Gazi University, Besevler, 06500 
      Ankara, Turkey.
FAU - Eroglu, Mehmet S
AU  - Eroglu MS
AD  - Department of Materials Science and Engineering, Technology Faculty, Marmara 
      University, Aydinevler, Maltepe, 34854, Istanbul, Turkey; TUBITAK-UME, Chemistry 
      Group Laboratories, PO Box 74, 41470, Gebze, Kocaeli, Turkey. Electronic address: 
      mehmet.eroglu@marmara.edu.tr.
LA  - eng
PT  - Journal Article
DEP - 20220715
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Hydroxides)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 459TN2L5F5 (poly(lactide))
RN  - CPD4NFA903 (Aluminum)
RN  - I38ZP9992A (Magnesium)
RN  - JJH7GNN18P (Ethylene Oxide)
SB  - IM
MH  - Aluminum
MH  - Ethylene Oxide
MH  - Hydroxides
MH  - Magnesium
MH  - *Nanoparticles/chemistry
MH  - Polyesters/chemistry
MH  - *Polyethylene Glycols/chemistry
MH  - Polymers/chemistry
OTO - NOTNLM
OT  - Mg-Al LDH
OT  - PLA
OT  - PLA/PEO electrospun mat
EDAT- 2022/07/16 06:00
MHDA- 2022/09/02 06:00
CRDT- 2022/07/15 19:24
PHST- 2022/04/14 00:00 [received]
PHST- 2022/07/03 00:00 [revised]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/07/16 06:00 [pubmed]
PHST- 2022/09/02 06:00 [medline]
PHST- 2022/07/15 19:24 [entrez]
AID - S0141-8130(22)01485-4 [pii]
AID - 10.1016/j.ijbiomac.2022.07.055 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2022 Sep 30;217:562-571. doi: 
      10.1016/j.ijbiomac.2022.07.055. Epub 2022 Jul 15.