PMID- 35840158
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20230105
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 49
IP  - 12
DP  - 2022 Dec
TI  - Antineutrophil Cytoplasm Antibody-Associated Vasculitides Valvular Impairment: 
      Multicenter Retrospective Study and Systematic Review of the Literature.
PG  - 1349-1355
LID - 10.3899/jrheum.211379 [doi]
AB  - OBJECTIVE: While myocardial impairment is a predictor of poor prognosis in 
      antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV), little is 
      known about valvular involvement. This study aims at describing the clinical 
      presentation, management, and outcome of endocarditis associated with AAV. 
      METHODS: We conducted a multicenter retrospective study in centers affiliated 
      with the French Vasculitis Study Group. We included patients with granulomatosis 
      with polyangiitis (GPA), microscopic polyangiitis (MPA), or eosinophilic GPA with 
      endocardial impairment. A systematic review was then performed through PubMed, 
      Embase, and Cochrane Library from inception up to September 2020. RESULTS: The 
      retrospective cohort included 9 patients (82%) with GPA, 1 (9%) with MPA, and 1 
      (9%) with unclassified AAV. Clinical presentation included acute valvular 
      insufficiency (n = 7, 64%), cardiac failure (n = 3, 27%), dyspnea (n = 3, 27%), 
      and no symptoms (n = 2, 18%). The aortic valve was the most frequently affected 
      (n = 8/10, 80%), and vegetations were noted in 4 of 10 patients (40%). Six 
      patients (55%) underwent surgical valvular replacement. No death from 
      endocarditis was reported. The systematic review retrieved 42 patients from 40 
      references: 30 (71%) had GPA, 21 (50%) presented with vegetations, the aortic 
      valve (n = 26, 62%) was the most frequently involved. Valvular replacement was 
      required in 20 cases (48%) and 5 patients (13%) died from the endocarditic 
      impairment. CONCLUSION: Endocarditis is a rare and potentially life-threatening 
      manifestation of AAV. Acute valvular insufficiency may lead to urgent surgery. 
      Implementing transthoracic echocardiography in standard assessment at baseline 
      and follow-up of AAV might reduce the delay to diagnosis and allow earlier 
      immunosuppressive treatment before surgery is needed.
CI  - Copyright (c) 2022 by the Journal of Rheumatology.
FAU - Jeantin, Lina
AU  - Jeantin L
AUID- ORCID: 0000-0001-6888-3311
AD  - L. Jeantin, MD, T. Lenfant, MD, P. Charles, MD, Department of Internal Medicine, 
      Institut Mutualiste Montsouris, Paris.
FAU - Lenfant, Tiphaine
AU  - Lenfant T
AUID- ORCID: 0000-0001-8992-6675
AD  - L. Jeantin, MD, T. Lenfant, MD, P. Charles, MD, Department of Internal Medicine, 
      Institut Mutualiste Montsouris, Paris.
FAU - Bataille, Pierre
AU  - Bataille P
AD  - P. Bataille, MD, Department of Nephrology, CH Boulogne-sur-Mer, Boulogne-sur-Mer.
FAU - de Boysson, Hubert
AU  - de Boysson H
AUID- ORCID: 0000-0001-9083-8365
AD  - H. de Boysson, MD, PhD, N. Martin Silva, MD, Department of Internal Medicine, CHU 
      Caen, Caen.
FAU - Cathebras, Pascal
AU  - Cathebras P
AUID- ORCID: 0000-0001-7570-3366
AD  - P. Cathebras, MD, Department of Internal medicine, Hopital Nord, CHU St Etienne, 
      St Etienne.
FAU - Agard, Christian
AU  - Agard C
AUID- ORCID: 0000-0002-1156-0607
AD  - C. Agard, MD, PhD, Nantes Universite, CHU Nantes, Department of Internal 
      Medicine, Nantes.
FAU - Faguer, Stanislas
AU  - Faguer S
AD  - S. Faguer, MD, PhD, Department of Nephrology and Organ Transplantation, Rangueuil 
      Hospital, Toulouse.
FAU - Poindron, Vincent
AU  - Poindron V
AD  - V. Poindron, MD, Referral Center for Autoimmune and Rare Systemic Diseases, 
      Strasbourg University Hospital, Strasbourg.
FAU - Ruivard, Marc
AU  - Ruivard M
AD  - M. Ruivard, MD, PhD, Department of Internal Medicine, CHU Estaing, CHU 
      Clermont-Ferrand, Clermont-Ferrand.
FAU - Silva, Nicolas Martin
AU  - Silva NM
AUID- ORCID: 0000-0002-1536-1373
AD  - H. de Boysson, MD, PhD, N. Martin Silva, MD, Department of Internal Medicine, CHU 
      Caen, Caen.
FAU - Monge, Matthieu
AU  - Monge M
AUID- ORCID: 0000-0002-7355-9126
AD  - M. Monge, MD, Hemodialysis Department, Institut Mutualiste Montsouris, Paris.
FAU - Guillevin, Loic
AU  - Guillevin L
AD  - L. Guillevin, MD, PhD, X. Puechal, MD, PhD, B. Terrier, MD, PhD, National 
      Referral Centre for Rare Systemic Autoimmune Diseases, Department of Internal 
      Medicine, CHU Cochin, Paris.
FAU - Puechal, Xavier
AU  - Puechal X
AUID- ORCID: 0000-0003-3573-9203
AD  - L. Guillevin, MD, PhD, X. Puechal, MD, PhD, B. Terrier, MD, PhD, National 
      Referral Centre for Rare Systemic Autoimmune Diseases, Department of Internal 
      Medicine, CHU Cochin, Paris.
FAU - Terrier, Benjamin
AU  - Terrier B
AD  - L. Guillevin, MD, PhD, X. Puechal, MD, PhD, B. Terrier, MD, PhD, National 
      Referral Centre for Rare Systemic Autoimmune Diseases, Department of Internal 
      Medicine, CHU Cochin, Paris.
FAU - Dechartres, Agnes
AU  - Dechartres A
AUID- ORCID: 0000-0003-0770-5567
AD  - A. Dechartres, MD, PhD, Sorbonne Universite, INSERM, Institut Pierre Louis 
      d'Epidemiologie et de Sante Publique, AP-HP, Hopital Pitie Salpetriere, 
      Departement de Sante Publique, Paris, France.
FAU - Charles, Pierre
AU  - Charles P
CN  - French Vasculitis Study Group
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20220715
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Humans
MH  - Retrospective Studies
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/diagnosis
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - *Microscopic Polyangiitis/complications
MH  - *Endocarditis/complications
MH  - Cytoplasm
MH  - *Granulomatosis with Polyangiitis/complications
MH  - Multicenter Studies as Topic
OTO - NOTNLM
OT  - antineutrophil cytoplasmic antibodies
OT  - heart valve diseases
OT  - noninfective endocarditis
OT  - vasculitis
EDAT- 2022/07/16 06:00
MHDA- 2022/12/06 06:00
CRDT- 2022/07/15 20:43
PHST- 2022/06/30 00:00 [accepted]
PHST- 2022/07/16 06:00 [pubmed]
PHST- 2022/12/06 06:00 [medline]
PHST- 2022/07/15 20:43 [entrez]
AID - jrheum.211379 [pii]
AID - 10.3899/jrheum.211379 [doi]
PST - ppublish
SO  - J Rheumatol. 2022 Dec;49(12):1349-1355. doi: 10.3899/jrheum.211379. Epub 2022 Jul 
      15.