PMID- 35841429 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220719 IS - 2199-1170 (Print) IS - 2198-9761 (Electronic) IS - 2198-9761 (Linking) VI - 8 IP - 1 DP - 2022 Jul 16 TI - The Impact of Pre-Exercise Carbohydrate Meal on the Effects of Yerba Mate Drink on Metabolism, Performance, and Antioxidant Status in Trained Male Cyclists. PG - 93 LID - 10.1186/s40798-022-00482-3 [doi] LID - 93 AB - INTRODUCTION: The consumption of yerba mate (YM), a source of antioxidants, in a fasted state increases fatty acid oxidation (FAT(ox)) during low-moderate-intensity exercise and improves performance in high-intensity exercise. However, the impact of a pre-exercise carbohydrate (CHO) meal on YM effects during exercise is unknown. OBJECTIVE: We investigated the effects of yerba mate drink (YMD) consumed in the fasted state (YMD-F) or after a CHO meal (YMD-CHO) on measurements of metabolism, performance, and blood oxidative stress markers in cycling exercise. METHODS: In a randomized, repeated-measures, crossover design, eight trained male cyclists ingested (i) YMD-CHO, (ii) YMD-F, or (iii) control-water and CHO meal (Control-CHO). The YMD (an infusion of 5 g of ultrarefined leaves in 250 mL of water) was taken for 7 days and 40 min before exercise. CHO meal (1 g/kg body mass) was consumed 60 min before exercise. The cycling protocol included a 40-min low-intensity (~ 53% V̇O(2peak)) constant load test (CLT); a 20-min time trial (TT); and 4 x 10-s all-out sprints. Blood samples and respiratory gases were collected before, during, and/or after tests. RESULTS: During CLT, YMD-CHO increased FAT(ox) ~ 13% vs. YMD-F (P = 0.041) and ~ 27% vs. Control-CHO (P < 0.001). During TT, YMD-CHO increased FAT(ox) ~ 160% vs. YMD-F (P < 0.001) and ~ 150% vs. Control-CHO (P < 0.001). Power output during TT improved ~ 3% (P = 0.022) in YMD-CHO vs. Control-CHO and was strongly correlated with changes in serum total antioxidant capacity (r = -0.87) and oxidative stress index (r = 0.76) at post-exercise in YMD-CHO. Performance in sprints was not affected by YMD. CONCLUSION: CHO intake did not negate the effect of YMD on FAT(ox) or TT performance. Instead, a synergism between the two dietary strategies may be present. Clinical Trial Registration NCT04642144. November 18, 2020. Retrospectively registered. CI - (c) 2022. The Author(s). FAU - Krolikowski, Thaiana C AU - Krolikowski TC AD - Graduate Program in Nutrition, Health Sciences Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-370, Brazil. FAU - Borszcz, Fernando K AU - Borszcz FK AD - Physical Effort Laboratory, Sports Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-900, Brazil. FAU - Panza, Vilma P AU - Panza VP AD - Graduate Program in Nutrition, Health Sciences Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-370, Brazil. FAU - Bevilacqua, Laura M AU - Bevilacqua LM AD - Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-370, Brazil. FAU - Nichele, Sarah AU - Nichele S AD - Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-370, Brazil. FAU - da Silva, Edson L AU - da Silva EL AD - Graduate Program in Nutrition, Health Sciences Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-370, Brazil. AD - Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-370, Brazil. FAU - Amboni, Renata D M C AU - Amboni RDMC AD - Department of Food Science and Technology, Agricultural Sciences Center, Federal University of Santa Catarina, Campus Itacorubi, Florianopolis, SC, 88034-001, Brazil. FAU - Guglielmo, Luiz G A AU - Guglielmo LGA AD - Physical Effort Laboratory, Sports Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-900, Brazil. FAU - Phillips, Stuart M AU - Phillips SM AD - Department of Kinesiology, McMaster University, Hamilton, ON, L8S 4K1, Canada. FAU - de Lucas, Ricardo D AU - de Lucas RD AD - Physical Effort Laboratory, Sports Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-900, Brazil. FAU - Boaventura, Brunna C B AU - Boaventura BCB AUID- ORCID: 0000-0002-2422-8945 AD - Graduate Program in Nutrition, Health Sciences Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-370, Brazil. brunnab@gmail.com. AD - Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Campus Trindade, Florianopolis, SC, 88040-370, Brazil. brunnab@gmail.com. LA - eng SI - ClinicalTrials.gov/NCT04642144 GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20220716 PL - Switzerland TA - Sports Med Open JT - Sports medicine - open JID - 101662568 PMC - PMC9287718 OTO - NOTNLM OT - Carbohydrate OT - Oxidative stress OT - Performance OT - Phenolic compounds OT - Substrate utilization OT - Yerba mate COIS- SMP reports grants from US National Dairy Council, during the conduct of the study; personal fees from US National Dairy Council, non-financial support from Enhanced Recovery, outside the submitted work. In addition, Dr. Phillips has a patent Canadian 3052324 issued to Exerkine, and a patent US 20200230197 pending to Exerkine but reports no financial gains. TCK, FKB, VP, LMB, SN, ELS, RDMCA, LGAG, RDL, and BCBB declare that they have no competing interests. EDAT- 2022/07/17 06:00 MHDA- 2022/07/17 06:01 PMCR- 2022/07/16 CRDT- 2022/07/16 11:25 PHST- 2021/11/11 00:00 [received] PHST- 2022/06/28 00:00 [accepted] PHST- 2022/07/16 11:25 [entrez] PHST- 2022/07/17 06:00 [pubmed] PHST- 2022/07/17 06:01 [medline] PHST- 2022/07/16 00:00 [pmc-release] AID - 10.1186/s40798-022-00482-3 [pii] AID - 482 [pii] AID - 10.1186/s40798-022-00482-3 [doi] PST - epublish SO - Sports Med Open. 2022 Jul 16;8(1):93. doi: 10.1186/s40798-022-00482-3.