PMID- 35841889
OWN - NLM
STAT- MEDLINE
DCOM- 20220815
LR  - 20220818
IS  - 1934-6069 (Electronic)
IS  - 1931-3128 (Print)
IS  - 1931-3128 (Linking)
VI  - 30
IP  - 8
DP  - 2022 Aug 10
TI  - HLA-B *46 associates with rapid HIV disease progression in Asian cohorts and 
      prominent differences in NK cell phenotype.
PG  - 1173-1185.e8
LID - S1931-3128(22)00310-9 [pii]
LID - 10.1016/j.chom.2022.06.005 [doi]
AB  - Human leukocyte antigen (HLA) alleles have been linked to HIV disease progression 
      and attributed to differences in cytotoxic T lymphocyte (CTL) epitope 
      representation. These findings are largely based on treatment-naive individuals 
      of European and African ancestry. We assessed HLA associations with HIV-1 
      outcomes in 1,318 individuals from Thailand and found HLA-B *46:01 (B *46) 
      associated with accelerated disease in three independent cohorts. B *46 had no 
      detectable effect on HIV-specific T cell responses, but this allele is unusual in 
      containing an HLA-C epitope that binds inhibitory receptors on natural killer 
      (NK) cells. Unbiased transcriptomic screens showed increased NK cell activation 
      in people with HIV, without B *46, and simultaneous single-cell profiling of 
      surface proteins and transcriptomes revealed a NK cell subset primed for 
      increased responses in the absence of B *46. These findings support a role for NK 
      cells in HIV pathogenesis, revealed by the unique properties of the B *46 allele 
      common only in Asia.
CI  - Published by Elsevier Inc.
FAU - Li, Shuying S
AU  - Li SS
AD  - Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, 
      WA 98104, USA.
FAU - Hickey, Andrew
AU  - Hickey A
AD  - Division of HIV Prevention, U.S. Centers for Disease Control and Prevention, 
      Atlanta, GA 30329, USA; Thailand Ministry of Public Health, U.S. Centers for 
      Disease Control and Prevention Collaboration, Nonthaburi 11000, Thailand.
FAU - Shangguan, Shida
AU  - Shangguan S
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Ehrenberg, Philip K
AU  - Ehrenberg PK
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA.
FAU - Geretz, Aviva
AU  - Geretz A
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Butler, Lauryn
AU  - Butler L
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Kundu, Gautam
AU  - Kundu G
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Apps, Richard
AU  - Apps R
AD  - Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, 
      USA.
FAU - Creegan, Matthew
AU  - Creegan M
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Clifford, Robert J
AU  - Clifford RJ
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Pinyakorn, Suteeraporn
AU  - Pinyakorn S
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Eller, Leigh Anne
AU  - Eller LA
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Luechai, Pikunchai
AU  - Luechai P
AD  - Division of HIV Prevention, U.S. Centers for Disease Control and Prevention, 
      Atlanta, GA 30329, USA; Thailand Ministry of Public Health, U.S. Centers for 
      Disease Control and Prevention Collaboration, Nonthaburi 11000, Thailand.
FAU - Gilbert, Peter B
AU  - Gilbert PB
AD  - Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, 
      WA 98104, USA.
FAU - Holtz, Timothy H
AU  - Holtz TH
AD  - Division of HIV Prevention, U.S. Centers for Disease Control and Prevention, 
      Atlanta, GA 30329, USA; Thailand Ministry of Public Health, U.S. Centers for 
      Disease Control and Prevention Collaboration, Nonthaburi 11000, Thailand; Office 
      of AIDS Research, National Institutes of Health, Bethesda, MD 20892, USA.
FAU - Chitwarakorn, Anupong
AU  - Chitwarakorn A
AD  - Department of Disease Control, Thailand Ministry of Public Health, Nonthaburi 
      11000, Thailand.
FAU - Sacdalan, Carlo
AU  - Sacdalan C
AD  - Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
FAU - Kroon, Eugene
AU  - Kroon E
AD  - Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
FAU - Phanuphak, Nittaya
AU  - Phanuphak N
AD  - Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
FAU - de Souza, Mark
AU  - de Souza M
AD  - Institute of HIV Research and Innovation, Bangkok 10330, Thailand.
FAU - Ananworanich, Jintanat
AU  - Ananworanich J
AD  - Department of Global Health, Amsterdam Medical Center, University of Amsterdam, 
      1105 BP Amsterdam, the Netherlands.
FAU - O'Connell, Robert J
AU  - O'Connell RJ
AD  - Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
FAU - Robb, Merlin L
AU  - Robb ML
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Michael, Nelson L
AU  - Michael NL
AD  - Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
FAU - Vasan, Sandhya
AU  - Vasan S
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA; Henry M. Jackson Foundation for the Advancement of 
      Military Medicine Inc., Bethesda, MD 20817, USA.
FAU - Thomas, Rasmi
AU  - Thomas R
AD  - U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 
      Silver Spring, MD 20910, USA. Electronic address: rthomas@hivresearch.org.
LA  - eng
GR  - AAI20052001/AI/NIAID NIH HHS/United States
GR  - UM1 AI068635/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20220715
PL  - United States
TA  - Cell Host Microbe
JT  - Cell host & microbe
JID - 101302316
RN  - 0 (Epitopes)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Disease Progression
MH  - Epitopes
MH  - *HIV Infections/metabolism
MH  - *HLA-B Antigens/genetics/metabolism
MH  - Humans
MH  - Killer Cells, Natural
MH  - Phenotype
PMC - PMC9380401
MID - NIHMS1817876
OTO - NOTNLM
OT  - CD4 counts
OT  - CITE-seq
OT  - HLA
OT  - KIR
OT  - NK cells
OT  - RNA-seq
OT  - Thailand
OT  - acute HIV infection
OT  - cytotoxic T lymphocytes
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2022/07/17 06:00
MHDA- 2022/08/16 06:00
PMCR- 2022/08/16
CRDT- 2022/07/16 18:43
PHST- 2021/11/30 00:00 [received]
PHST- 2022/01/17 00:00 [revised]
PHST- 2022/06/09 00:00 [accepted]
PHST- 2022/07/17 06:00 [pubmed]
PHST- 2022/08/16 06:00 [medline]
PHST- 2022/07/16 18:43 [entrez]
PHST- 2022/08/16 00:00 [pmc-release]
AID - S1931-3128(22)00310-9 [pii]
AID - 10.1016/j.chom.2022.06.005 [doi]
PST - ppublish
SO  - Cell Host Microbe. 2022 Aug 10;30(8):1173-1185.e8. doi: 
      10.1016/j.chom.2022.06.005. Epub 2022 Jul 15.