PMID- 35842539
OWN - NLM
STAT- MEDLINE
DCOM- 20230511
LR  - 20230524
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 37
IP  - 7
DP  - 2023 May
TI  - Short-term progression of optic disc and macular changes in optic nerve head 
      drusen.
PG  - 1496-1502
LID - 10.1038/s41433-022-02155-7 [doi]
AB  - PURPOSE: To quantify in patients with optic nerve head drusen (ONHD)changes after 
      1-year observation in: (i) optic disc and (ii) macular optical coherence 
      tomography (OCT) parameters and (iii) the effect of age at enrolment in the 
      study. DESIGN: Prospective, cross-sectional observational study using Spectral 
      Domain-OCT (Copernicus; OPTOPOL Technology S.A., Zawiercie, Poland) imaging was 
      carried out in 35 patients with ONHD (age-42.8 +/- 19.9 years; males = 15; 
      females = 20) at baseline and after 12 months follow-up. RESULTS: Patients with 
      ONHD had significant thinning of the surface nerve fibre layer in the central 
      (p = 0.03), superior (p = 0.05) and inferior (p = 0.04) areas; mean ppRNFL 
      thinning (p = 0.0 4) and ppRNFL thinning in the nasal segment (p = 0.028). 
      Retinal thinning in the central (p = 0.001), inner (p = 0.01) and outer 
      (p = 0.002) temporal, outer superior (p = 0.03) and inferior (p = 0.02) areas; 
      borderline ganglion cell layer thinning (p = 0.051) and outer nuclear layer 
      (p = 0.03) thinning in the central retina and outer segment layer thinning 
      nasally (p = 0.01) between the first and the second visit in macula. Correlation 
      of the difference in optic disc and macular parameters with the age at enrolment 
      did not reveal any significance. CONCLUSIONS: Statistically detectable thinning 
      of the optic nerve and macula structures occurred already after 12 months. The 
      proximity of optic nerve changes to the vascular arcades can possibly be 
      explained by involvement of retinal vessels in the pathophysiology of ONHD.
CI  - (c) 2022. The Author(s).
FAU - Pilat, Anastasia V
AU  - Pilat AV
AD  - Ophthalmology Group, University of Leicester, Leicester, UK. 
      ap410@leicester.ac.uk.
AD  - East Sussex NHS Healthcare Trust, Sussex, UK. ap410@leicester.ac.uk.
FAU - Proudlock, Frank A
AU  - Proudlock FA
AD  - Ophthalmology Group, University of Leicester, Leicester, UK.
FAU - Kumar, Periyasamy
AU  - Kumar P
AD  - Leicester Royal Infirmary, Leicester, UK.
FAU - Gottlob, Irene
AU  - Gottlob I
AD  - Ophthalmology Group, University of Leicester, Leicester, UK.
AD  - Cooper Medical School of Rowan University and Cooper University Healthcare, 
      Camden, NJ, USA.
LA  - eng
GR  - MC_PC_17171/MRC_/Medical Research Council/United Kingdom
GR  - MR/J004189/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/N004566/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Observational Study
DEP - 20220716
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - *Optic Disk
MH  - Retinal Ganglion Cells
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - Nerve Fibers
MH  - *Optic Disk Drusen
MH  - Tomography, Optical Coherence/methods
PMC - PMC10169844
COIS- The authors declare no competing interests.
EDAT- 2022/07/17 06:00
MHDA- 2023/05/11 06:42
PMCR- 2022/07/16
CRDT- 2022/07/16 23:21
PHST- 2021/11/18 00:00 [received]
PHST- 2022/06/16 00:00 [accepted]
PHST- 2022/06/09 00:00 [revised]
PHST- 2023/05/11 06:42 [medline]
PHST- 2022/07/17 06:00 [pubmed]
PHST- 2022/07/16 23:21 [entrez]
PHST- 2022/07/16 00:00 [pmc-release]
AID - 10.1038/s41433-022-02155-7 [pii]
AID - 2155 [pii]
AID - 10.1038/s41433-022-02155-7 [doi]
PST - ppublish
SO  - Eye (Lond). 2023 May;37(7):1496-1502. doi: 10.1038/s41433-022-02155-7. Epub 2022 
      Jul 16.