PMID- 35844516
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20221207
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Allele and Haplotype Frequencies of HLA-A, -B, -C, and -DRB1 Genes in 3,750 Cord 
      Blood Units From a Kinh Vietnamese Population.
PG  - 875283
LID - 10.3389/fimmu.2022.875283 [doi]
LID - 875283
AB  - The frequencies and diversities of human leukocyte antigen (HLA) alleles and 
      haplotypes are representative of ethnicities. Matching HLA alleles is essential 
      for many clinical applications, including blood transfusion, stem cell 
      transplantation, and tissue/organ transplantation. To date, the information about 
      the frequencies and distributions of HLA alleles and haplotypes among the Kinh 
      Vietnamese population is limited because of the small sample size. In this study, 
      more than 3,750 cord blood units from individuals belonging to the Kinh 
      Vietnamese population were genotyped using PCR sequence-specific oligonucleotide 
      (PCR-SSO) for HLA testing. The results of the study demonstrated that the most 
      frequently occurring HLA-A, -B, -C, and -DRB1 alleles were A*11:01 (25%), A*24:02 
      (12.3%), A*02:01 (11.2); A*03:03 (8.95%), A*02:03 (7.81%), A*29:01 (7.03%); 
      B*15:02 (15.1%), B*46:01 (10.7%), B*58:01 (7.65%), B*38:02 (7.29%); C*08:01 
      (17.2), C*07:02 (16.2%), C*01:02 (15.2), C*03:02 (8.3%), C*15:05 (6.13); 
      DRB1*12:02 (31.0%), DRB1*09:01 (10.47%), DRB1*15:02 (7.54%); DRB1*07:01 (6.68%), 
      DRB1*10:01 (6.63%), respectively, with the highest allele diversity level 
      observed in locus B (93 alleles). The most frequent haplotypes of two-locus 
      combinations of HLA-A-B, HLA-A-C, HLA-A-DRB1, HLA-B-C, HLA-B-DRB1, and HLA-C-DRB1 
      haplotypes were A*11:01-B*15:02 (7.63%), A*11:01-C*08:01 (7.98%), 
      A*11:01-DRB1*12:02 (10.56%), B*15:02-C*08:01 (14.0%), B*15:02-DRB1*12:02 
      (10.47%), and C*08:01-DRB1*12:02 (11.38%), respectively. In addition, the most 
      frequent haplotypes of three- and four-locus sets of HLA-A-B-C, HLA-A-B-DRB1, 
      HLA-A-C-DRB1, HLA-B-C-DRB1, and HLA-A-B-C-DRB1 were A*11:01-B*15:02-C*08:01 
      (7.57%), A*11:01-B*15:02-DRB1*12:02 (5.39%), A*11:01-C*08:01-DRB1*12:02 (5.54%), 
      B*15:02-C*08:01-DRB1*12:02 (10.21%), and A*11:01-B*15:02-C*08:01-DRB1*12:02 
      (5.45%), respectively. This study provides critical information on the 
      frequencies and distributions of HLA alleles and haplotypes in the Kinh 
      Vietnamese population, accounting for more than 85% of Vietnamese citizens. It 
      paves the way to establish an umbilical cord blood bank for cord blood 
      transplantation programs in Vietnam.
CI  - Copyright (c) 2022 Que, Khanh, Khanh, Van Son, Van Anh, Anh, Tung and Thang.
FAU - Que, Tran Ngoc
AU  - Que TN
AD  - Stem Cell Bank, National Institute of Hematology and Blood Transfusion, Pham Van 
      Bach, Cau Giay, Hanoi, Vietnam.
AD  - Department of Hematology, Hanoi Medical University, 1 Ton That Tung, Dong Da, 
      Hanoi, Vietnam.
FAU - Khanh, Nguyen Ba
AU  - Khanh NB
AD  - Stem Cell Bank, National Institute of Hematology and Blood Transfusion, Pham Van 
      Bach, Cau Giay, Hanoi, Vietnam.
AD  - Department of Hematology, Hanoi Medical University, 1 Ton That Tung, Dong Da, 
      Hanoi, Vietnam.
FAU - Khanh, Bach Quoc
AU  - Khanh BQ
AD  - Stem Cell Bank, National Institute of Hematology and Blood Transfusion, Pham Van 
      Bach, Cau Giay, Hanoi, Vietnam.
AD  - Department of Hematology, Hanoi Medical University, 1 Ton That Tung, Dong Da, 
      Hanoi, Vietnam.
FAU - Van Son, Chu
AU  - Van Son C
AD  - Key Laboratory of Enzyme and Protein Technology, VNU University of Science, 
      Vietnam National University-Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam.
FAU - Van Anh, Nguyen Thi
AU  - Van Anh NT
AD  - Key Laboratory of Enzyme and Protein Technology, VNU University of Science, 
      Vietnam National University-Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam.
FAU - Anh, Tran Thi Thuy
AU  - Anh TTT
AD  - Faculty of Biology, VNU University of Science, Vietnam National University-Hanoi, 
      334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam.
FAU - Tung, Pham Dinh
AU  - Tung PD
AD  - Department of Probability and Statistics, Faculty of 
      Mathematics-Mechanics-Informatics, VNU University of Science, Vietnam National 
      University, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam.
FAU - Thang, Nguyen Dinh
AU  - Thang ND
AD  - Faculty of Biology, VNU University of Science, Vietnam National University-Hanoi, 
      334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam.
LA  - eng
PT  - Journal Article
DEP - 20220629
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - *Fetal Blood/physiology
MH  - Gene Frequency
MH  - *HLA Antigens/blood/genetics
MH  - HLA-A Antigens/blood/genetics
MH  - HLA-B Antigens/blood/genetics
MH  - HLA-C Antigens/blood/genetics
MH  - HLA-DRB1 Chains/blood/genetics
MH  - Haplotypes
MH  - Humans
MH  - Vietnam
PMC - PMC9277059
OTO - NOTNLM
OT  - Kinh Vietnamese population
OT  - allele
OT  - cord blood
OT  - haplotype
OT  - human leukocyte antigen (HLA)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/19 06:00
MHDA- 2022/07/20 06:00
PMCR- 2022/01/01
CRDT- 2022/07/18 03:38
PHST- 2022/02/15 00:00 [received]
PHST- 2022/05/30 00:00 [accepted]
PHST- 2022/07/18 03:38 [entrez]
PHST- 2022/07/19 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.875283 [doi]
PST - epublish
SO  - Front Immunol. 2022 Jun 29;13:875283. doi: 10.3389/fimmu.2022.875283. eCollection 
      2022.